Transcript Medical Technologies International, Inc. (MTI)

From Outer Space…
To Your Doctor’s Office
ArterioVision™ CIMT
presented to
Federal Laboratory Consortium
Mid-Atlantic Region Meeting
by
Medical Technologies International, Inc.
Gary F. Thompson, Chairman and CEO
23 October 2007
Summary
• We help detect and treat Heart
Disease and Stroke.
• We do this non-invasively, using
existing ultrasound equipment.
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MTI - Making a Positive Difference Every Day
The Need
• Cardiovascular Disease (CVD) = #1 killer
in the United States…soon to be
worldwide
• 1 American dies of CVD every 36
seconds
• CVD claims more lives than the next 4
leading causes of death…combined
• 66% of unexpected cardiac deaths occur
with no prior symptoms
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MTI - Making a Positive Difference Every Day
Win / Win
• ArterioVision™ CIMT complements
current standard of care
• Clinical pathway for other exams and
treatment
• Patient Benefits
• Improved Practice Financials
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MTI - Making a Positive Difference Every Day
A Case Presentation
• Male, Age 50, Caucasian
– Strong family history of CVD
• All males died before age 50
• Each had no prior symptoms
– Lifetime of Fitness
• Amateur athlete
• Marathoner since 1975
– Non-smoker
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MTI - Making a Positive Difference Every Day
A Case Presentation
Patient Tests
• Weeks before 50th birthday, tested
non-invasive procedures & biomarkers
•
•
•
•
•
•
Berkeley Heart Lab Comprehensive Panel
hsCRP
Stress echo
Nuclear perfusion
Genetic testing
CT scan / CCS
• Valuable/Standard of Care Tests
• All Results Negative / Normal or Better
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MTI - Making a Positive Difference Every Day
A Case Presentation
Patient Event
• At age 50, ran L.A. Marathon
– Mile 15 developed back pain
– Ran until mile 20
• Myocardial infarction LAD
• Lost 48% of heart muscle
• “It is not what happens to you in life that matters, as
much as what you do about it.” –Anonymous
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MTI - Making a Positive Difference Every Day
A Case Presentation
HIPAA – Patient’s Permission – Full Disclosure
• Business Boards at Caltech
– David Baltimore
• Recommendation
– Beta test site University Hospital
• Did not provide prior history
• 15 minutes and $500
• Outcome
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MTI - Making a Positive Difference Every Day
Initial CIMT Exam – 1996
AGE 50:
CIMT Value of
2.043 mm
591% greater risk for heart
attack or coronary death
-------------------
Tot Chol = 174
HDL = 50
LDL = 101
BP = 110/65
HR = 48
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MTI - Making a Positive Difference Every Day
MTI & “The Company We Keep”
First-Rate Partners
Cutting-edge science developed by Caltech,
JPL Biomedical Research Program &
USC’s Keck School of Medicine Atherosclerosis Research Program
Exclusive, perpetual worldwide license
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MTI - Making a Positive Difference Every Day
Image Acquisition &
Analysis Co-Inventors
• Robert Selzer
• Howard Hodis
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MTI - Making a Positive Difference Every Day
A Few Other Key MTI Team Members
• Kelly Nardoni
• Stephen Polly
• JoAnne Thompson
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MTI - Making a Positive Difference Every Day
TV News Segment
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MTI - Making a Positive Difference Every Day
ArterioVision™ CIMT
Unique Features
•
•
FDA Clearance: Only device approved for
measurement AND risk assessment
Proprietary database of CIMT values from
patients asymptomatic for CVD
•
Works with any brand of ultrasound
machine
•
Makes better use of existing equipment
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MTI - Making a Positive Difference Every Day
ArterioVision™ CIMT
Unique Features
• Measures surrogate endpoint of
disease
• Directly measures vascular damage
at the arterial wall level
• Automated edge detection using
subpixel interpolation
• Helps monitor treatment efficacy
through serial examinations
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MTI - Making a Positive Difference Every Day
ArterioVision™ CIMT
Unique Features
• FDA-Cleared Patient Report
– Behavioral Modification Tool
– Chronological Age vs. Arterial Age
– % Risk for Events
• Gets the Patient’s Attention
– Increased Patient Compliance
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MTI - Making a Positive Difference Every Day
ArterioVision™ CIMT
Acquisition & Analysis Flexibility
Analyze images on
dedicated PC loaded
with analysis software
(provided by MTI)
Acquire patient images
with any brand ultrasound
equipment, using MTI’s
patented protocol
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MTI - Making a Positive Difference Every Day
ArterioVision™ CIMT
Analysis
Demonstration
by
Jonathan Mullane, Account Executive
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MTI - Making a Positive Difference Every Day
Vascular Disease Can Be Reversed
2006 - Age 60 CIMT Value of 1.021 mm
Reduction of CIMT by 50%
in 10 years.
How?:
• Great MDs & RXs
• Serial annual CIMT exams
• Other testing continued with
same Negative / Normal or
better results
• No red meat
• 2 adult beverages / day
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MTI - Making a Positive Difference Every Day
Conclusion
•
NASA/JPL help save lives…on
Earth
•
MTI is growing rapidly
•
Tell us which doctor you want us to
visit
•
Patient brochures, etc.
•
“Making a Positive Difference
Every Day”
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MTI - Making a Positive Difference Every Day
Q&A
“It is not what happens to you in life that
matters, as much as what you do about it.”
–Anonymous
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MTI - Making a Positive Difference Every Day
Appendix
Summary Studies
&
Societal Guidelines
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MTI - Making a Positive Difference Every Day
Studies
• Over 2,700 published, peer-reviewed manuscripts consistently and
conclusively link CIMT with:
• Subclinical atherosclerosis
• Cardiovascular risk factors and CVD; and hence
• Potential for future cardiovascular events
• Landmark studies showing CIMT is related to the risk of clinical cardiovascular
events include:
• Salonen, 1993
• Chambless, 1997
• Bots, 1997
• Hodis, 1998
• O’Leary, 1999
• Chambless, 2000
• Lorenz, 2006
• Bibliography available upon request
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MTI - Making a Positive Difference Every Day