Transcript Plagiarism

Molecular Science at
Creighton University:
A brief overview
Patrick C. Swanson, Ph.D.
NE Biomedical Research Retreat
November 16, 2006
RESEARCH AREAS
 Osteoporosis Research Center
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Robert Recker, M.D.
Genetics and physiology of bone mass
Robert Heaney, M.D.
Bone biology and calcium nutrition
Joan M. Lappe, Ph.D., R.N.
Factors influencing bone health in children,
adolescents, and post-menopausal women
Diane Cullen, Ph.D.
John (Jack) Yee, Ph.D.
Mohammad Akhter, Ph.D.
Lpr5 function and Wnt signaling on skeletal
development, growth, and biomechanical properties
Effect of smoke exposure on bone physiology
RESEARCH AREAS
 Hearing Loss and Regeneration
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Bernd Fritzsch, Ph.D.
Development/survival of inner ear sensory neurons
Kirk Beisel, Ph.D.
Molecular delineation of inner ear signaling pathways
Richard Hallworth, Ph.D.
Biophysics and biomechanics of cochlear cell motility
David He, Ph.D.
Mechanico-electrical transduction in the inner ear
Garret Soukup, Ph.D.
Function of microRNAs, riboswitches, and ribozymes
in regulation of gene expression and ear development
David Nichols, Ph.D.
Development and cell motility in the auditory system
RESEARCH AREAS
 Cancer Biology and Genetics
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Henry Lynch, M.D. (Hereditary Cancer Center)
Familial cancers (breast/ovarian, colorectal, and
pancreatic cancers, heteditary multiple myeloma)
Brian Loggie, M.D. (CUMC Cancer Center)
Peritoneal and rectal-associated malignancies
Zhaoyi (Charlie) Wang, Ph.D. (CUMC Cancer Center)
Estrogen signaling in breast cancer
Venkatesh Govindarajan (GV), Ph.D. (CUMC CC)
Development and tumor biology of ocular, skin
and skeletal tissue
Laura Hansen, Ph.D.
Signal transduction in skin biology/carcinogenesis
Yaping Tu, Ph.D.
G protein signaling in prostate cancer
RESEARCH AREAS
 Allergy, Asthma, and Inflammation
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Thomas Casale, M.D.
Robert Townley, M.D.
Againdra Bewtra, M.D.
Russel Hopp, D.O.
Adult and pediatric asthma/allergy pathophysiology
Pharmacotherapy of allergic and respiratory diseases
Smoking as a risk factor for development of asthma
Devendra Agrawal, Ph.D.
Pathophysiology of allergy and bronchial asthma
Inflammatory diseases of blood vessels
Dale Bergren, Ph.D.
Lung C-fiber activation in airway hyper-irritability
RESEARCH AREAS
 Antibiotic resistance / molecular epidemiology
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Ken Thomson, Ph.D.
Phil Lister, Ph.D.
Nancy Hanson, Ph.D.
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Center for Research in
Anti-infectives and
Biotechnology (CRAB)
Molecular mechanisms of antibiotic resistance
Pharmacodynamics of antibiotics
Development of diagnostic tests
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Rich Goering, Ph.D.
Molecular techniques for microbial diagnosis and
epidemiology
RESEARCH AREAS
 Infectious Disease/Immunology
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Kristen Drescher, Ph.D.
Immune factors involved in demyelinating diseases
Jason Bartz, Ph.D. (NCV)
Anthony Kincaid, Ph.D.
Routes and mechanisms of prion transport
Michael Belshan, Ph.D. (NCV)
Mechanisms of HIV replication and pathogenesis
Patrick Swanson, Ph.D.
Mechanisms of antigen receptor diversification
B lymphocyte development, tolerance, and disease
Martha Gentry-Nielsen, Ph.D.
Influence of smoke and alcohol exposure on
susceptibility to pneumococcal infection
RESEARCH AREAS
 Biomedical Science
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Roger Reidelberger, Ph.D.
Molecular mechanisms regulating food intake and
energy reserves (obesity)
Philip Brauer, Ph.D.
Mechanisms controlling neural crest cell migration
(cardiac and craniofacial abnormalities)
Laura Bruce, Ph.D.
Ontogenetic/phylogenetic development of CNS
Rita Meyer, Ph.D.
Roles of gap junction communication in limb
development
RESEARCH AREAS
 Biomedical Science (Regulatory Peptides)
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Sandor Lovas, Ph.D.
Richard Murphy, Ph.D.
Structure-activity relationships in regulatory peptides
D. David Smith, Ph.D.
Polypeptide synthesis
Robert Mackin, Ph.D.
Regulation and specificity of enzymes involved
in peptide hormone synthesis
RESEARCH AREAS
 Pharmacology
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Thomas Murray, Ph.D.
Neurotoxicology and glutamate receptor
pharmacology
Peter Abel, Ph.D.
Frank Dowd, Ph.D.
Charles Bockman, Ph.D.
Margaret Scofield, Ph.D.
Pharmacology, genetic regulation, and signal
transduction of G protein-coupled receptors,
including adrenergic and neuropeptide receptors
RESEARCH AREAS
 Pathology
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Ward Pedersen, Ph.D.
Insulin resistance and Alzheimer’s disease
Qinglong Hu, M.D.
Molecular biology of lymphoma and leukemia
Lisa MJ Lee, Ph.D.
Metastatic melanoma
CORE FACILITIES
 Nebraska Center for Cell Biology
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Richard Hallworth, Ph.D.
LSM 510 META confocal scanning system
- Multi-photon, with Time-Correlated Single Photon Counting capability
- Fluorescence Lifetime Imaging (FLIM), Fluorescence Correlation
Spectroscopy (FCS), Fluorescence Resonance Energy Transfer (FRET)
 Creighton University Flow Cytometry Facility
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Patrick Swanson, Ph.D. and Greg Perry, Ph.D.
BD FACSCalibur and FACSAria systems
 Molecular Biology Core Facility
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Joseph Knezetic, Ph.D.
DNA sequencing, synthesis, etc.
 Morphology Core Facility
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William Hunter III, M.D.
Transmission and scanning electron microscopy
SOM RESEARCH FUNDING
Federal Sources
70
N = 62
60
50
40
30
20
N=6
10
N=2
0
DOD
NIH
NSF
Held mostly by basic science department primary faculty (42)
or faculty in Centers with clinical or secondary appointments (~20)