Transcript MEG & Integration of Multiple Imaging Technologies

Interventional MRI
Magnetoencephalography
Verification of Functional Imaging with
Interventional MRI: Mapping of
Epilepsy and Eloquent Cortex
Steven Stufflebeam, M.D. (MGH)
Ronald Kikinis, M.D. (BWH)
Partners Radiology Research Award
Interictal Spike Localization
MEG
Brain Connectivity
Structural Connectivity:
DTI Tractography
Greg Sorensen
Functional Connectivity:
BOLD fMRI
Vincent & Buckner, 2006
Effective Connectivity:
MEG dynamic SEM
Fa-Hsuan Lin
Combining Advanced Imaging Technologies:
Sum is greater than the Parts
Tumor, MEG, MRAngo,
DTI fMRI
Stephen Piper, Ph.D.
Language Mapping in Temporal Lobe Tumor
T2 MRI Tumor
Isopoential
Field Maps
(MEG)
DTI
Dr. Alexandra Golby
C
Dr. Ralph Suarez
Dr. Ronald Kikinis.
Dr. Stufflebeam
MEG
Dipole For
Language
Stimuli
Dr. Alex Golby
Dr. Ralph Suarez.
Dr. Stufflebeam
Why is this research important?
• Translational research: bench to bedside.
• Multidisciplinary and cross-institutional: Physics,
software engineering, mathematics, neurosurgery,
neurology.
• Leverages the resources of the BWH & MGH to
advance researchdirectly to patients/physicians.
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250 epilepsy & brain tumor patients from MGH/BWH
Awards at ISCAMEG, HBM, ISB
HST.583 Imaging Biophysics & Clin Apps
Grants R01, P41, K08, K25, CIMIT
Thanks
BWH
• Ron Kikikis
• Stephen Piper
• Ferenc Jolesz
• Ralph Suarez
• Alexandra Golby
• Joseph Madsen
• Ed Bromfield
• Barabara Dworetzky
• Jong Lee
MGH/Martinos Center
• Emad Eskandar
• Reese Cosgrove
• Andy Cole
• Ronan Kilbride
• Matti Hamalainen
• Fa-Hsuan Lin
• Greg Sorensen
• Randy Buckner
• Gordon Harris
• Giorgio Bonmassar