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Biotech hotbed
Uppsala BIO
Uppsala BIO is an initiative from the local biotech industry, the two universities in Uppsala and regional development bodies. Its aim is to promote the long-term growth of the biotech sector in the region.
Why hotbed?
Look at what grows here
• Successful start-ups • Fast-movers • Global-leaders
Olink – a new biotech start-up
Olink, a venture between university researchers and local entrepreneurs, has developed a new method of analyzing proteins. In one format, the technology uses high-precision micro structures made via polymer replication.
Jonas Jarvius, Ph.D. student, Uppsala University, and co-founder of Olink
Olink – success factors
• Outstanding research facilities (Rudbeck and Ångström labs) • Close proximity to local companies (e.g. Åmic) • Support from Uppsala BIO-X plus local entrepreneurs • Uppsala’s track record of commercializing biotech innovation • Followed a well-proven pathway (innovation, patent, proof-of-principle, market need, business plan, initial financing)
NeoPharma – fast track to market and sales
NeoPharma’s first pharmaceutical, Duodopa ® , has been approved for the treatment of Parkinson’s disease in Sweden and nine other European countries.
Ulf Rosén, CEO, NeoPharma Christer Nyström, Professor, Uppsala University
NeoPharma – success factors
• Access to staff and management with solid experience from the industry • Pharmaceutical research at the university’s Department of Pharmacy • Hospital staff and researchers coordinate clinical evaluation with NeoPharma (principle investigator at the hospital) • Close proximity to Swedish Medical Products Agency (MPA) • MPA acts as reference member state for marketing authorization in EU within the framework of the Mutual Recognition Procedure
Q-Med – world-leader in facial esthetics. Growing force in medical implants.
RESTYLANE™ products dominate the world market for filling out lips, wrinkles and folds. DEFLUX™ and ZUIDEX™ enjoy increasing success in treating uro gynecological disorders.
Bengt Ågerup, founder and CEO, Q-Med
Q-Med – success factors
• Corporate HQ exercises complete global responsibility • One center for business strategy, R&D, clinical research, product manufacture, marketing and sales • Skilled personnel available in the region – ‘from people who understand production to those who know how to sell’ • In house ‘business school’ promotes individual development • International location
National perspective
Sweden’s business climate
• Wages among the lowest in Europe, especially for scientists • Corporate tax (28%) is the continent’s next lowest • Dividends from foreign subsidiaries not subject to Swedish taxation • Deregulated society and infrastructure • Recognized success in high-tech industrial ventures • People work across company and organizational borders
Source: Invest in Sweden Agency Biotechnology Report, 2002.
Powerful force in biotechnology
• Europe’s fourth largest biotech industry (biggest in relation to population/GDP) • Best climate for biotech research and innovation plus the highest quality workforce* • Fruitful collaboration between industry, universities and public healthcare • • • Academic researchers retain commercial rights to their discoveries Support from experienced life science venture capitalists Centralized public health system with unique medical and genetic records
Source: Invest in Sweden Agency Biotechnology Report, 2002.
*Cap Gemini Ernst & Young.
European biotech industry 2003
European companies per country Source: Ernst & Young
Uppsala’s strengths in biotechnology
Uppsala has been described as the world’s ‘most biotech concentrated city’.
Unbroken tradition of scientific achievement C. Linnæus T. Svedberg A. Tiselius Century Scientist
18th 18th 18th 18th 19th 19-20th M. Siegbahn 19-20th T. Svedberg 20th 20th 20th 20th O. Rudbeck C. Linnæus A. Celcius J.J. Berzelius A. J. Ångström A. Tiselius K. Siegbahn J.Porath, P. Flodin G. Johansson, H. Bennich, L. Wide
Achievement
The lymphatic system Systema Naturæ classification Thermometric scale ( °C) Chemical elements (Se, Th, Si, Ti, Z) Modern spectroscopy (Å unit) X-ray spectroscopy Ultracentrifuge Electrophoresis Electron spectroscopy Gel filtration Immunoglobulin E
Nobel prize
Unrivalled track-record of commercial success
Pharmacia Biotech Amersham Biosciences
GE Healthcare
10 000 MUSD
Pharmacia Diagnostics
204 MUSD
Personal Chemistry
14 MUSD
Biotage
(Personal Chemistry and Pyrosequencing)
Q-Med
78 MUSD
Pyrosequencing
13 MUSD
Biacore
67 MUSD
NeoPharma
3 MUSD
AMO Uppsala
114 MUSD
1940 1960 1980 2000 Electrophoresis Dextran Function of Hyaluronic acid IgE SPR Biosensors Duodopa Microwave synthesis Pyrosequencing
Turnover for 2003
The region for your next research, investment or business venture
The competence to develop biotechnology
• More than half of Sweden’s biotech firms in the 70-kilometer Uppsala – Stockholm corridor • Uppsala University, the University Hospital and the Swedish University of Agricultural Sciences in the north • Karolinska Institute (KI), Stockholm University and the Royal Institute of Technology (KTH) in the south • Almost 10% of Uppsala’s workforce employed in biotech-related businesses
Tools for Life Science Employees:
Approx. 1,500 in privately-owned industries in Uppsala
Speciality:
Drug discovery systems, medical diagnostics, protein separations
Pharmaceuticals and biomedical devices Employees:
Approx. 1,800 in privately owned industries in Uppsala
Speciality:
Improved drug delivery is a strong niche
Diagnostics Employees:
Approx. 600 in privately owned industries in Uppsala
Speciality:
Both human and veterinary applications
The skills to develop biotechnology
• Broad industrial expertise and business know-how • Steady supply of young scientists (many with MBAs) and ideas • Leading center for clinical research and trials • Home of the Swedish Medical Products Agency, the National Food Administration, the National Veterinary Institute, and the WHO monitoring center for drug side-effects • Leading role in Human Proteome Project
Uppsala Biotech Sector Basic research Swedish Agricultural University, Uppsala University Research tools and platforms Biacore, Biotage, GE Healthcare, Gyros, Olink, Quiatech, Uppsala Imanet, Åmic Discovery and development Innoventus, NeoPharma, Orexo, Pharmacia Diagnostics, Q-Med, Resistentia Pharmaceuticals Scaling up Production to full GMP Fresenius Kabi, Pfizer, GIN-laboratory, NeoPharma, Q-Med Health and medical care University Hospital Clinical research University Hospital, Uppsala Clinical Research Center, Centre for Clinical Testing of Foodstuffs Documentation and registration Eureda, Quintiles, Statisticon, MPA (also reference member state for authorization in the EU)
Leading campus areas
•
Biomedical Centre
– chemistry, pharmacology, surface biotechnology, bioinformatics •
Linnæus Center for Bioinformatics
•
Ångström Laboratory
– material sciences, physics, energy, MEMS •
Center for Mathematics and Information Technology
•
Uppsala Genetics Center
– plant biology and forest genetics •
Veterinary Medicine Center
•
Ludwig Institute for Cancer Research
•
Rudbeck Laboratory
– molecular genetics and medicine •
University Hospital
– clinical research, clinical trials •
Uppsala Clinical Research Center
University Hospital clinical research, clinical trials Rudbeck Laboratory molecular genetics and medicine Uppsala BIO Center for Mathematics and Information Technology MPA Medical Products Agency Uppsala Clinical Research Center Ångström Laboratory material sciences, physics, energy, MEMS Dag Hammarskjölds väg Biomedical Centre chemistry, pharmacology, surface biotechnology, bioinformatics Linnæus Center for Bioinformatics Ludwig Institute for Cancer Research SVA National Veterinary Institute Veterinary Medicine Center Uppsala Genetics Center plant biology and forest genetics
The will to develop biotechnology
• Strong culture of academic/industrial and company/company collaboration • Open attitude plus world-class biotech and clinical research • Post-Pharmacia atmosphere of innovative ideas and business skills • Strong networks and close personal ties • ‘Teachers’ exemption’ (researchers retain commercial rights to their discoveries)
The resources to develop biotechnology
• ‘Serial entrepreneurs’ with many years experience • Uppsala – Stockholm region is the center of Swedish venture capital • Clear insight into how to turn innovative ideas into commercial successes • Uppsala Innovation Centre, the region’s foremost business incubator, supports the potential in new biotech ideas
Complete innovation concept Finance Venture and industrial capital Growth companies Start-up companies Know-how Incubator programs Seed financing Business plan Business idea Entrepreneur skills and training Pre-seeding Patent Innovation Research and education Advice and scouting
Investing in Uppsala
Invest in Uppsala promotes international expansion and works before, during and after your decision to invest in the region. Free-of-charge services include: • • • • • • •
Help with all aspects of physical planning Contact with authorities and organizations Locating office and industrial premises Partners and match-making Staff recruitment Housing and accommodation Personalized study visits
www. uppsala.se/investinuppsala
Living and working in Uppsala
• Sweden ranked 2nd out of 175 countries in the UN 2004 Human Development Index • Uppsala excels in lifestyle and living standards • Two universities of great breadth and diversity • Small town prosperity, cosmopolitan atmosphere • Countryside, forests and breathtaking coastal region • International location
Source: Invest in Uppsala
London 2.5 h Stockholm 40 min Beijing 8 h Boston 12 h Arlanda 30 min
Regional/industry challenges
•
Many small biotech companies
– how to secure venture capital, make them profitable, and get them to stay following mergers •
Competence
– awaken young persons’ interest in science and management skills •
Fill the pipeline
– establish research fields plus technology transfer •
Infrastructure
– secure transition from university town to science city
Regional action plan
Promote the long-term growth of biotechnology
• Research • Innovation program • Competence and training • Communication
•
Academia
•
Industry Uppsala BIO-X
•
Seminar
•
series Scientific conferences Schools $
• • •
Innovation System Incubator Business Lab Entrepreneurs Program Competence chain Business Support for
• • •
existing companies Partnering Further education Regional infrastructure Universities Innovators Entrepreneurs Marketing Biotech in Uppsala Industries
Research
Uppsala BIO-X – the cross-disciplinary research effort focused on Life Science Supports ambitious projects based on cutting-edge science with the potential to generate new opportunities for industry Supplementary funding and resources (mainly for stimulating the formation of multi-disciplinary research teams)
Innovation program
Scouting for spin-offs at universities and industry Incubators focused on commercialization, financing and future viability Entrepreneurship and Alumni programs Access to a broad external network of business advisors and financers Seed-funding for life science projects
Competence and training
Promote science programs at schools and universities Attract young people to science Encourage more frequent contact between university and industry Set up management and leadership programs for next generation entrepreneurs Push the development of housing, transport and schools
Communication
Tell the world what happens in Uppsala via website, publications, e-newsletter, congresses, etc.
Arrange international arenas for meetings, networking and partnering Create a local understanding of and support for biotechnology Help make the right contacts in industry, research, finance, etc.
Vision – one of the world’s top five biotech regions
• Frontline biotech research • Outstanding innovation climate • Close academic/industrial collaboration • Seasoned serial entrepreneurs • Full industrial/business infrastructure • International location
Contact Uppsala BIO
Uppsala BIO
Uppsala Science Park Dag Hammarskjölds v. 60 SE-751 83 Uppsala Sweden [email protected]
www.uppsalabio.com