The Center of Excellence for Diabetes at University of Texas School of Public Health, Brownsville Regional Campus Staff and Faculty

POVERTY LOW EDUCATIONAL ATTAINMENT LOW IMMUNIZATION RATES LACK OF MEDICAL INSURANCE INFECTIOUS DISEASES VECTOR-BORNE DISEASES INCREASES IN CHRONIC DISEASES

Cameron & Hidalgo Counties = poorest in the U.S. in terms of: % of all residents + those <18 + those >65 who are below poverty level % with less than a high school diploma % high school graduate or higher % with a B.A. degree or more % in labor force Median household income Median family income Percent speaking only Spanish: Texas: 27 % Brownsville: 87 %

Susan Fisher-Hoch, Anne Rentfro, Hossein Rahbar, Gloria Sanchez, Craig Hanis & Joseph McCormick

University of Texas Houston School of Public Health and University of Texas at Brownsville

MD000170 P20: Funded from the NIH National Center on Minority Health and Health Disparities.

Cameron County Hispanic Cohort (CCHC) Study design

2000 Census: Quartiles by mean income (SES)

1 2 3 4

STRATA LEVEL 1 LEVEL 2 CLINIC VISIT

Select first quartile Select third quartile Random selection of tracts/blocks All households enumerated.

All occupied residences visited

Household questionnaire

Current activity 5-year follow up Glucose transition study Intervention studies Phase I: weighted data Randomly selected individual aged 35-64 yrs Phase 2 All other household members > 18 yrs

Individual questionnaire Demographics Socioeconomics Medical History Medications Family History Behavioral Factors Anxiety/Depression Clinical exam Laboratory Anthropometry Blood pressure EKG Cognitive Function Fasting blood for: glucose/HbA1c/CBC insulin/ lipid profiles/LFTs DNA for genome studies RNA for gene expression Plasma for multiplexing archived sera/cells

Obesity

• 50% of the entire population is obese • A further 31% are overweight

Diabetes

• 19% of the entire population has diabetes • • Nearly 5% of diabetes is undiagnosed Half of the diabetes patients are not on medication

Men are at special risk

• Younger men are more obese than younger women • • • • Younger men are considerably more obese than older men A cohort effect and/or obese men dying earlier?

Men develop diabetes earlier than women Men are more likely to have undiagnosed diabetes than women

Metabolic and Inflammatory markers

• Insulin resistance is above normal limits, all age groups • C-reactive protein is well within normal limits, all age groups.

Our infrastructure Center of Excellence in Diabetes in Americans of Mexican descent, Hispanic Health Research Center and The University of Texas at Brownsville BSL2 BSL3 6000 sq ft wet lab space with qPCR, FACSCanto, Luminex system, LC/MS freezer archive, 2 full time techs and many students Clinical Research Unit (2,387 sq.ft) Staff & cohort participant at Valley Baptist Brownsville Hospital CRU Medical Director Rose Gowen

Classrooms with ITV Computer lab Data management Etc.