Transcript Breast Cancer Research . ppt

Breast Cancer Research
Michael J Kerin | Professor of Surgery & Research Director, NBCRI
Breast Cancer Research, School of Medicine
NCRI Predictions 2005-2035
Breast Cancer Incidence in Ireland
6000
2010-2030: 53% increase in incidence
4833
 1771
No. of Cases
5000
3484
 623
4000
3000
2781 
137
2196
2000
1000
0
2005
2015
2025
2035
Year
Breast Cancer Research, School of Medicine
Total No. of Breast Cancer Cases 2003-2010
University Hospital Galway
600
529
No. of cases
500
406
396
400
257
300
269
234
197
200
129
100
0
2003
2004
2005
2006
2007
2008
2009
2010
Year
Breast Cancer Research, School of Medicine
Symptomatic Breast Clinic 2009 Annual Report
• 2003-2009: number of patients attending the unit
increased from 3475 to 9671
• Breast cancer diagnoses increased from 110 to
529 per annum
• 2005-2009: 61-68% of women have been
treated with breast conservation surgery
• 61% of women were given a a post-mastectomy
immediate breast reconstruction
Breast Cancer Research, School of Medicine
UHG Breast Clinic Team
Breast Cancer Research, School of Medicine
Breast Cancer Research
• Laboratory established by Professor Fred Given in 1991
• National Breast Cancer Research Institute (NBCRI) charity
funding has enabled research development
• Comprehensive specimens biobank and database chaptering over 20 years
of patients
• National & international scientific and clinical collaborators
Breast Cancer Research, School of Medicine
Core Research Projects
West of Ireland Population –
genetic predisposition to breast
cancer
Single Nucleotide Polymorphisms
and microRNA
Population Genetics
University of Oxford
Yale University
Tumour Tissue & Blood Studies
In vitro migration, apoptosis,
proliferation assays
MicroRNA
Neoadjuvant Chemotherapy
Breast Cancer Research
NUI Galway
EMBL, Nottingham Trent University
In vivo model
Mesenchymal Stem Cells for
Gene Delivery
In vivo imaging studies
REMEDI, University of Arizona, Mayo Clinic
Tumour Microenvironment
Cellular Interactions/Chemokines
Postgraduate & Undergraduate Researchers
2005-2011
50
49
45
36
40
35
29
30
Total
NBCRI Funded
20
25
20
15
10
5
0
Postgrad
Undergrad
70% of our student
researchers are
partially or fully
funded by NBCRI
Breast Cancer Research, School of Medicine
Molecular Profiling:
Cancer Genes
Research Questions?
What genes are involved in causing breast cancer?
Are genes affected by chemotherapy, radiotherapy etc?
Can we develop a cancer gene profile that will improve diagnosis and treatment
of breast cancer?
Breast Cancer Research, School of Medicine
Gene & Cell Therapy:
Adult Stem Cells
• Stem cells have the potential to develop into many different cell types in the
body
• Do they develop into cancer cells?
• Can they be used to target cancer cells?
• Can cells “home” to bone, lungs?
Breast Cancer Research, School of Medicine
MicroRNA & Gene Profiling Research Team
Nicola Miller PhD
•
Research Supervisor
•
Colorectal Cancer
– Dr Kah Hoong Chang
– Dr Mary Nugent
Breast Cancer
– Dr Aoife Lowery PhD
– Dr Helen Heneghan
– Dr Nuala Healy
•
Prostate Cancer
– Dr Brian Kelly
– Dr Ailbhe McDermott
– Dr Ronan Glynn
Breast Cancer Research, School of Medicine
Stem Cells & Tumour Microenvironment
Research Team
Roisin Dwyer PhD
Research Supervisor
– Sonja Khan MSc
– James Ryan MSc
– Dr Shirley Potter
– Dr Marion Hartmann
– Dr Fiachra Martin
– Dr John Kelly
Breast Cancer Research, School of Medicine
Population Genetics Research Team
• Nicola Miller PhD
Research Supervisor
• Breast Cancer
– Dr Niall McInerney
– Dr Gabrielle Colleran
– Dr Jemima Dorairaj
Breast Cancer Research, School of Medicine
Breast Cancer Management Research
How has the clinical management of breast cancer changed?
Minimally invasive diagnostic techniques, screening
Breast Conserving Surgery
Sentinel Lymph Node Biopsy
Oncoplastics & Reconstruction
Molecular Biology Research
Article published
Sept 2009
Breast Cancer Research, School of Medicine
Recent High Impact Publications
Stem Cells
June 2011
(REMEDI, Arizona, Mayo
Clinic Collaboration)
The Lancet Oncology,
March 2011
(Yale Collaboration)
Breast Cancer Research, School of Medicine
Recent High Impact Publications
JNCI, December 2010
(Oxford Collaboration)
Breast Cancer Research, School of Medicine
International Impact of Publishing Research
Clinical Cancer Research 2007
Cited by 91 other studies
Annals of Surgery,
March 2010
50 citations
Breast Cancer Research, School of Medicine
Clinical and Preclinical Trials
• Irish Cooperative Research Group (ICORG)
Trial opened in May 2011
Investigating the effect of neoadjuvant therapy on microRNA expression in breast
cancer
• Preclinical Translational Trials in Animal Models
We are translating what we have found in the lab to an in vivo model.
The animal facility is based in REMEDI, NUI Galway.
Strict ethical guidelines regulate this field of research
Breast Cancer Research, School of Medicine
Research Collaborators
International
•
Yale University, USA (Dr Frank Slack)
•
University of Arizona (Dr Harrison Barrett)
•
The Mayo Clinic, US (Dr John Morris)
•
University of Oxford (Prof Ian Tomlinson, Dr Ellie Sawyer)
•
European Molecular Biology Laboratory, Germany (Dr Vladimir Benes)
•
Nottingham Trent University, UK (Dr Graham Ball)
•
Baylor University, Texas (Kent Osborne, Rachel Schiff)
National
•
Biomedical Diagnostic Institutes, DCU
Local
•
Molecular Diagnostic Research Group, NUI Galway (Dr. Tom Barry)
•
REMEDI, NUI Galway (Prof Tim O’Brien, Prof Frank Barry)
•
Clinical Research Facility Biostatistics Unit (Dr John Newell)
Breast Cancer Research, School of Medicine
€7
5,
00
0
€750,000
€1
45
,0
00
€1,500,000
€2
80
,0
00
€2,250,000
€9
93
,3
01
€3,000,000
€2
,9
00
,0
00
Funding Income 2004-2011
CRI
RCSI
€0
NBCRI
HRB
MMI
Breast Cancer Research, School of Medicine
Recent Funding Awards
Breast Cancer Campaign, UK
• €100,000 (2011-2015)
SFI Biomedical Diagnostic Institute
• €400,000 (2011-2015)
• Postdoctoral Scientist and Research Assistant employed in April 2011 in
collaboration with Molecular Diagnostics Research Group
Breast Cancer Research, School of Medicine
How your money is spent
Laboratory Supplies
& Equipment
Conference
Attendance
Researcher
Salary/Fellowship
Journal Publication
Fees
Maintenance of
Cancer Biobank &
Database
Undergraduate Summer
Research School
Breast Cancer Research, School of Medicine
UHG Clinical Breast Service
Breast Research Facilities
Breast Cancer Research, School of Medicine
Translation Research Facility:
Breast Cancer Research for the Future
Cois Coiribe 2009: NUI Galway Alumni Publication
Architect image of TRF. To be located on UHG campus
Breast Cancer Research, School of Medicine
Breast Cancer Biobank
• Collection of patient specimens and data that may be used for
research
• Ethically approved
• Patient Consent
• Largest breast cancer biobank in Ireland
• Over 4000 patients registered
• Multiple specimens per patient
Breast Cancer Research, School of Medicine
Fundraising Groups: Friends of NBCRI
• Galway – Anna O’Coinne
• Mullingar – Joe Duffy
• Dublin – Goretti Newell,
Miriam Hand
• Sligo – Oonagh Monahan
• Ennis – Monica Gallagher
• Castlebar –Lourda McHugh
• ICA, ILGU, Jim Bolger
Breast Cancer Research, School of Medicine
NBCRI Fundraising Events
Into the West Cycle (Mullingar to Galway…and back!)
Breast Cancer Research, School of Medicine
Cois Cladaigh
Christmas
Concert
December 2010
Tea at the G
Oct 2010
(Afternoon
Tea/Fashion
Show)
Breast Cancer Research, School of Medicine
NBCRI Fundraising Events
California Walking Challenge 2010
2011 Destinations
Sweden (July)
New York (November)
Breast Cancer Research, School of Medicine
Other NBCRI Fundraising Events
•
•
•
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National Sponsored Cycles, Walks, Marathons
Table Quizzes, Race nights
Fashion shows
Coffee mornings, lunches
Supermarket bag pack
Car Wash
Golf AM-AM
Gala Dinners (e.g. Valentine’s Ball, Galway)
Auctions
Record breaking – Get in the Guinness Book of Records and help breast
cancer Research!
Breast Cancer Research, School of Medicine
For more information…
Website @ www.nbcri.ie
Research Newsletter 2011
Breast Cancer Research, School of Medicine
Radical
Mastectomy
Fisher
NSABP
CMFCAF
Taxotere
Molecular
Classification
Simple
Mastectomy
Tamoxifen
Her2neu
Future Developments
• Breast Cancer care will continue to improve with
individualisation of therapy
• High volume unit improves patient outcomes
• Enhanced specialist expertise of next generation by
combining science and medicine for patient benefit
• Local and National Research Collaborators
• Quality International Research Output from West of Ireland
Breast Cancer Research, School of Medicine