Transcript Nurina Khimatus S (G1F011022)

KELOMPOK 1
Nurina Khimatus S (G1F011022)
Ruth Febrina (G1F011006)
Dedah Nurhamidah (G1F011008)
Inas Ghausani (G1F011012)
Khilman Husna (G1F011036)
Windhiana Sapti (G1F011038)
Muhammad Rifki Hadafi (G1F011042)
Vidya Nur A (G1F011048)
Aisyah Putriani (G1F011050)
Rangsangan Nyeri
Glukokortikoid
Membran fosfolipid
Fosfolipase A2
Asam arakhidonat
Lipooksigenase
(LOX)
NSAID
Siklooksigenase
(COX)
Endoperoksida siklik
5-HPETE
Celecoxib
LTA4, LTB 4,LTC4, LTD4,
LTE4
COX- 2
COX -1
TXA2
PG
PG
Protasiklin
STEROID
E.Fospolipase
SUBSTRAT
AINS
As.Arakidonat
E.Siklooksigenase
se
A.
Arakidonat
Prostaglandin
Prostasiklin
Tromboksan A2
Coxib
E.Siklooksigenase 2
As.
Arakidonat
Prostaglandin
Prostasiklin
Selektif
(celecoxib)
COX1 ->Tromboxan
A2
Trombosis
COX 2 -> Prostasiklin
LOX-> Leukotrien
NSAID
Asma
Non Selektif
(Aspirin)
Tukak
Lambung
Tromboxan A2 → agregasi platelet &
vasokonstriksi
Prostasiklin → inhibitor agregasi platelet &
vasodilator
Leukotrien → bronkokonstriksi
Prostaglandin COX1 → pelindung mukosa
COX
COX 1 ->
Prostaglandin
COX 2