Case Presentation
Download
Report
Transcript Case Presentation
CASE PRESENTATION
Myra Lalas
HPI
16 yo male previously healthy who presented to the
Peds ED with:
sore throat and dysphagia x 4 days
Fever x 3 days (Tm = 105.3)
L neck and shoulder pain x 1 day
Headache x 1 day
Decreased PO
NBNB emesis x 1 yesterday
Diarrhea 4 days ago
Hematuria
No abdominal pain
No rhinorrhea
No cough
No rash
No sick contacts
No recent travel
PMH
None
No known allergies
Shots UTD
FMH
noncontributory
HEADSS
Lives with both parents and brother.
In 11th grade
Denies EtOH, nicotine, illicit drugs
Sexually active, uses condoms, 3 SP’s, (-) STD history
PE
VS T 100 BP 110/54 P 128 R 28 99%RA
GEN Uncomfortable, has difficulty moving due to
neck pain
HEENT NCAT, PERLLA, EOMI, MMM, OP clear, (+) Lsided tenderness to palpation, with some erythema
CHEST (+) rhonchi on R base
HEART N S1/S2, no murmurs
ABD soft, (+) BS, NT/ND, no HSM, no CVA
tenderness
EXT FEP, CRT < 2 s
NECK no Kernig’s, no Brudzinski’s
LABS
CBC
Blood Culture
CMP
D dimer
Fibrinogen
Coags
UA
Urine culture
Imaging
CXR- normal
CT Scan Chest: multiple lesions in b/l lung fields
CT abd/pelvis for hematuria: (+) nodules at b/l
lung fields
Neck US: b/l cervical LAD; (+) L IJV thrombus in
superior cervical portion into tributary
ER Course
BP dropped to 90/40- received NS bolus x 2
Peds ID consulted: thrombus likely infected and
spreading septic emboli to lungs; showing signs of
sepsis and DIC w/c may explain ARF and crea of
2.1
Start Vanco, Flagyl, and Ceftriaxone
Differentials?
Cat scratch disease
Candidiasis
Cellulitis
Endocarditis
Mastoiditis
Pharyngitis
Sinusitis
Superficial thrombophlebitis
Lemierre’s Disease
Jugular vein thrombophlebitis
Usual sources of infection:
Tonsil
Pharynx/
URTI
Chest/ LRTI
Middle ear/ mastoid
Larynx
Dental
Paranasal sinus
Usual First Clinical Symptoms
Sore throat
Neck mass
Neck pain
Bone/ joint pain
Otalgia and/or otorrhea
Dental pain
Orbital pain
GI symptoms
Microbiology
Fusobacterium necrophorum
Other Fusobacterium sp.
Eikenella corrodens
Porphyromonas asaccharolytica
Streptococci including S. pyogenes
Bacteroides
Pathophysiology
Production of bacterial toxins (e.g., LPS) leads to
secretion of cytokines by leukocytes- SEPTIC
SYMPTOMS
Production of hemagglutinin- causes platelet
aggregation that can lead to DIC and
thrombocytopenia
Inflammation and septic thrombophlebitis gives rise
to distant emboli that usu. migrate to pulmonary
capillaries
Sites of Septic Mets
Lungs
Joints
Knee
Hip
Sternoclavicular
Shoulder
elbow
joint
Diagnostics
High resolution CT Scan with contrast- probably the
most useful investigation for jugular or vena caval
suppurative thrombophlebitis and may demonstrate
soft tissue swelling and filling defects or thrombus
Venography
US- not useful in regions deep to the clavicle or
mandible
Treatment
removal of the initiating focus of infection (eg,
intravenous catheter)
prompt initiation of high dose intravenous antibiotics
surgical consultation and intervention
consideration of anticoagulation.
Antibiotics
a beta-lactamase resistant beta-lactam antibiotic is
recommended for the treatment of this infection:
Ticarcillin-clavulanate (3.1 g IV every four hours) or
imipenem (500 mg to 1 g every six hours).
The duration of therapy generally is for at least
four weeks or until pulmonary abscesses have
resolved by CT scan.
Surgery
Surgical exploration, with ligation or excision of the
internal jugular vein is occasionally required.
Surgical drainage of pulmonary abscesses or
empyema may be necessary.
Anticoagulation
Remains controversial as its use has not been
properly assessed due to the low incidence of the
disease
References
Karkos et al. Lemierre’s syndrome: a systematic
review. The Laryngoscope. 2009: The American
Laryngological, Rhinological and Otological Society,
Inc; pp. 1-8.
www.uptodate.com