Transcript Pancreas Transplant Categories

Patient Survival
USA Primary DD Pancreas Transplants 1/1/2004 – 12/31/2008
Category
n
PTA
491
PAK
1,136
SPK
4,206
2/09
1Yr Surv.
96.4%
96.6%
95.2%
IPTR UNOS
/
Major Causes of Patient Death
USA Primary DD Pancreas Transplants 1/1/2004 – 12/31/2008
%
SPK
0-3
3-12
PAK
> 12
0-3
PTA
3-12
> 12
0-3
3-12
> 12
Months Posttransplant
3/09
IPTR UNOS
/
1-Year Patient Survival
USA Primary DD Pancreas Transplants 1/1/2004 – 12/31/2008
3/08
IPTR UNOS
/
Risk Factors for Patient Survival
USA DD Primary Pancreas Transplants, 1/1/2004 – 12/31/2008
Higher
Risk
Lower
IPTR UNOS
/
Pancreas Graft Function
USA DD Primary Pancreas Transplants 1/1/2005 – 12/31/2009
Cat.
SPK
PAK
PTA
3/10
n
4,146
947
465
1Yr Fxn
85%
79%
78%
p < 0.0001
IPTR UNOS
/
Pancreas Graft Function
USA DD Primary Pancreas Transplants 1/1/2004 – 12/31/2008
DWFx Pancreas censored
Cat.
PAK
PTA
SPK
3/09
n
1,136
491
4,200
1Yr Fxn
81.0%
81.0%
88.2%
p < 0.0001
IPTR UNOS
/
Major Causes of Px Graft Failure
USA Primary DD Pancreas Transplants 1/1/2004 – 12/31/2008
%
SPK
0-<3
3-<12
≥ 12
PAK
0-<3
3-<12
≥ 12
PTA
0-<3
3-<12
≥12
Months Posttransplant
3/09
IPTR UNOS
/
1-Year Pancreas Graft Function
USA DD Primary Pancreas Transplants 1/1/2000 – 12/31/2007
SPK
PAK
PTA
%
100
90
80
70
60
50
4-14
15-29
30-44
Donor Age [Yrs]
4/06
45-59
IPTR UNOS
/
Hazard Ratio for Pancreas Graft Loss
USA DD Primary Pancreas Transplants, 1/1/2000 – 12/31/2005
2.5
2.5
Hazard Ratio
SPK
2.5
PTA
PAK
2
2
2
1.5
1.5
1.5
1
1
1
0.5
0.5
0.5
0
0
0
Risk
Lower
45
30
-5
-4
-2
9
4
9
-5
-4
4
-1
15
4
45
30
-2
9
4
9
9
-5
4
-4
4
9
-2
-1
4
-1
15
4
45
30
15
4
Donor Age
Higher
IPTR UNOS
/
Hazard Ratio for Pancreas Graft Loss
USA DD Primary Pancreas Transplants, 1/1/2000 – 12/31/2007
Hazard Ratio
2
Higher
1.5
1
Risk
Lower
0.5
0
PT
A
K
K
PA
SP
Donor Cause of Death Trauma vs. Non-Trauma
IPTR UNOS
/
1-Year Pancreas Graft Function
USA DD Primary Pancreas Transplants 1/1/2000 – 12/31/2006
SPK
PAK
PTA
%
100
90
80
70
60
50
< 18.5
18.5 - 24.9
25.0-29.9
Donor BMI
4/08
>30
IPTR UNOS
/
1-Year Pancreas Graft Function
USA DD Primary Pancreas Transplants 1/1/2000 – 12/31/2006
SPK
PAK
PTA
%
100
90
80
70
60
50
0 - 11
12 - 23
Preservation Time [Hrs]
4/06
24 36
IPTR UNOS
/
Hazard Ratio for Pancreas Graft Loss
USA DD Primary Pancreas Transplants, 1/1/2000 – 12/31/2005
2.5
2.5
Hazard Ratio
SPK
2.5
PAK
PTA
2
2
2
1.5
1.5
1.5
1
1
1
0.5
0.5
0.5
0
0
Higher
Risk
Lower
0
-3
6
Preservation Time [hrs]
4
6
25
-3
-2
6
4
4
13
-2
2
-1
-3
-1
2
25
1
25
-2
2
-1
13
0
1
13
IPTR UNOS
/
Technical Failure Rate
USA DD Primary Pancreas Transplants 1/1/2000 – 12/31/2005
%
20
P = 0.0001
15
Donor Cause of Death
10
Trauma
Non-Trauma
5
0
SPK
PAK
PTA
IPTR UNOS
/
Graft Thrombosis Rate
USA DD Primary Pancreas Transplants 1/1/2000 – 12/31/2005
%
20
P = 0.0001
15
Donor Cause of Death
10
Trauma
Non-Trauma
5
0
SPK
PAK
PTA
IPTR UNOS
/
Hazard Ratio for Technical Failure
USA DD Primary Pancreas Transplants, 1/1/2000 – 12/31/2005
2.5
2.5
Hazard Ratio
SPK
2.5
PAK
PTA
2
2
2
1.5
1.5
1.5
1
1
1
0.5
0.5
0.5
0
0
0
Higher
Risk
Lower
46
31
-6
-4
-3
-6
-4
0
5
0
0
5
0
0
5
5
-1
16
4
46
31
-3
-6
-4
0
5
-1
16
4
46
31
-3
5
-1
16
4
Donor Age
IPTR UNOS
/
Hazard Ratio for Graft Thrombosis
USA DD Primary Pancreas Transplants, 1/1/2000 – 12/31/2005
2.5
2.5
Hazard Ratio
SPK
2.5
PAK
PTA
2
2
2
1.5
1.5
1.5
1
1
1
0.5
0.5
0.5
0
0
0
Higher
Risk
Lower
46
31
-6
-4
-3
-6
-4
0
5
0
0
5
0
0
5
5
-1
16
4
46
31
-3
-6
-4
0
5
-1
16
4
46
31
-3
5
-1
16
4
Donor Age
IPTR UNOS
/
Hazard Ratio for Graft Thrombosis
USA DD Primary Pancreas Transplants, 1/1/2000 – 12/31/2005
Hazard Ratio
2
Higher
1.5
1
Risk
Lower
0.5
0
A
PT
K
K
PA
SP
Donor Cause of Death Trauma vs. Non-Trauma
IPTR UNOS
/
Immunological Pancreas Graft Loss
USA Primary TS DD Pancreas Transplants 1/1/2004 – 12/31/2008
Cat.
PTA
PAK
SPK
3/09
n 1Yr Loss
445
6.0%
1,016
5.5%
3,879
2.1%
p = 0.0001
IPTR UNOS
/
Even the Highest Risk Patients Do Better with a
SPK than Remaining on the Waiting List
UNOS Pancreas Waiting List
1/1/1995– 5/31/2003
100
University of Minnesota SPK
Recipients
%
80
60
40
20
0
0
12
24
36
48
Months Waiting
2/04
IPTR UNOS
/
IPTR UNOS
/