Transcript Pathology of the ovary.

Pathology of the ovary
WHO CLASSIFICATION OF TUMORS OF THE OVARY
(2003)
1. Surface epithelial-stromal tumors
• Serous tumors
- malignant: adenocarcinoma, surface papillary
adenocarcinoma, adenocarcinofibroma
- borderline: papillary cystic tumor, surface papillary
tumor, adenofibroma, cystadenofibroma
- benign: cystadenoma, adenofibroma,
cystadenofibroma, surface papilloma
• Mucinous tumors
- malignant: adenocarcinoma,adenocarcinofibroma
- borderline: intestinal type, endocervical-like
- benign: cystadenoma, adenofibroma, mucinous cystic
tumor with pseudomyxoma peritonei
• Endometrioid tumors including variants with squamous
differentiation
- malignant: adenocarcinoma,adenocarcinofibroma,
malignant mullerian mixed tumor (carcinosarcoma)
- borderline: cystic tumor, adenofibroma
- benign: cystadenoma, adenofibroma
• Clear cell tumors
- malignant: adenocarcinoma, adenocarcinofibroma
- borderline: cystic tumor, adenofibroma
- benign: cystadenoma, adenofibroma
• Transitional cell tumors
- malignant: transitional cell carcinoma (non-Brenner
type), malignant Brenner tumor
- borderline: Brenner tumor (proliferating type)
- benign: Brenner tumor
• Squamous cell tumors
malignant and benign
• Mixed epithelial tumors
malignant,borderline,benign
• Undifferentiated and unclasified tumors
2. Sex cord-stromal tumors
• Granulosa-stromal cell tumors
- Granulosa cell tumor group:
adult, juvenile
- Thecoma-fibroma group:
thecoma, fibroma, fibrosarcoma
• Sertoli-stromal cell tumors
- Sertoli-Leydig stromal cell group
• Sex cord-stromal tumors
of mixed or unclassified cell types
sex cord tumor with annular tubules, gynandroblastoma
• Steroid cell tumor
3. Germ cell tumors
• Primitive germ cell tumors
- Dysgerminoma
- yolk sac tumor
- embryonal carcinoma
-polyembryoma
- non-gestational choriocarcinoma
• Biphasic or triphasic teratoma
- immature teratoma
- mature teratoma
dermoid cyst
• Monodermal teratoma
- thyroid tumor group
struma ovarii
- carcinoid group
- neuroectodermal tumor group
-carcinoma group
adenocarcinoma,squamous cell carcinoma
- melanocytic group
- sarcoma group
- etc....
4. Germ cell sex cord-stromal tumors
5. Tumors of the rete ovarii
6. Miscellaneous tumors
7. Tumor-like conditions
- luteoma of pregnancy
- stromal hyperthecosis
- stromal hyperplasia
- fibromatosis
- massive ovarian edema
- others
8. Lymphoid and hematopoietic tumors
9. Secondary tumors
Surface epithelial-stromal tumors
etiology
risk factors
Benign serous tumors
Benign serous tumors
gross and microscopic features
Borderline serous tumors
Serous adenocarcinoma
Serous adenocarcinoma
gross and microscopic features
Benign mucinous tumors
Benign mucinous tumors
gross and microscopic features
Borderline mucinous tumors
Mucinous adenocarcinoma
Mucinous adenocarcinomas
gross and microscopic features
Pseudomyxoma peritonei
Endometrioid tumors
Endometrioid adenocarcinoma
Endometrioid adenocarcinoma
gross and microscopic features
Sex cord-stromal tumors
Granulosa cell tumor group
Granulosa cell tumor group
Adult granulosa cell tumor
Juvenile granulosa cell tumor
Thecoma-fibroma group
Thecoma
Thecoma
Fibroma
Germ cell tumors
Malignant transformation of germ cell
• Mature
• Benign
mature cystic teratoma
struma ovarii
• Malignant
squamous carcinoma
carcinoid
thyroid carcinoma
• Embryonal
(multipotential)
• Undifferentiated
dysgerminoma
• Primitive
embryonal carcinoma
• Somatic immature
teratoma
• Trophoblast
choriocarcinoma
• Extraembryonic
yolk sac carcinoma
Mature teratoma
Mature teratoma
dermoid cyst
Monodermal teratomas
Immature (malignant) teratomas
Dysgerminoma