Transcript 101 1 functional neuroanatomy introduction

國立陽明大學一百學年度第一學期
授課進度表
科目名稱：功能性神經解剖學 Functional Neuroanatomy （科目代號：
時
間：週五下午 13:30-14:30
地
點：圖資大樓 845 室 授課系級：腦科所碩博士班一年級
授課教師： 李怡慧等腦科所及榮總教師
日
期
） 學分數：一學分
聯絡電話：28712121 ext 8109
講
題
時
1
數 教師姓名(中文)
1-3. 李怡慧
1. 20120921
Chap 3. Gross anatomy of the nervous system
Chap 4. Meningeal coverings of the brain and spinal cord
2. 20120928
3. 20121005
Chap 5. Ventricles and cerebrospinal fluid
Chap 6. Blood supply of the brain
Chap 24. Formation, modification and repair of neural connections
4. 20121012
5. 20121019
Chap 11. Organization of the brain stem
Chap 12. Cranial nerves and their nuclei
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1
4-5. 李宜中
6. 20121026
7. 20121102
Chap 18. Overview of motor system
Chap 19. Basal ganglia
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1
6-7. 林永煬
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8. 20121109 The autonomic and enteric nervous system
9. 20121116
10. 20121123 Chap 16. Thalamus and internal capsule
11. 20121130 Chap 22. Cerebral cortex
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8-9. 盧俊良
12. 20121207 Chap 23. Hypothalamus and limbic system
13. 20121214
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12-13. 蘇東平
14. 20121221 Chap 10. Spinal cord
15. 20121228
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14-15. 蔡昀岸
16. 20130104 Functional connectivity in the brain
17. 20130111
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16-17. 杜培基
10-11. 陳韋達
18. 李怡慧
18. 20130118 期末考
附註：請將本課程各授課教師之授課時數統計後填列於下表
授
課
時
數
統
計
教
師
李怡慧
級
職
時
數
教
師
級
職
時
數
助理教授
4
林永煬
教授
2
盧俊良
教授
2
蘇東平
教授
2
李宜中
助理教授
2
蔡昀岸
醫師
2
杜培基
助理教授
2
陳韋達
助理教授
2
教
師
級
教科書名： The Human Brain: An Introduction to Its Functional Anatomy, 6th edition, 2009
作
者： John Nolte
出版社： Mosby
職
時
數
http://www.studentconsult.com
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e-mail: [email protected]
password: ihuilee
Gross Neuroanatomy
CNS
vs
PNS
Neuroanatomy
CNS
Nuclei (gray matter) vs. nerve tracts (white matter)
Brain, functional areas
Spinal cord
Blood-brain barrier
Ventricular system
Blood supply
PNS
Cranial, cervical to sacral nerves, autonomic nerves
muscles
Methods
Lesion studies
Special stains (Golgi, Nissel) and histology
Tract tracing
Surface-, Intracortical microstimulation
PET, (f)MRI, EEG, MEG, TMS
Phineas Gage--1848
Neurons are signaling elements
Late nineteenth century: Golgi and Ramon y Cajal
Mapping brain regions
Wilder Penfield, 1940’s
Electrical stimulation of
exposed human cortex
during surgery
Methods for functional studies
Limbic lobe
Cranial nerves
Diencephalon and brainstem
C-shaped structures
Somatotopic mapping of human
sensory and motor cortices
CNS
subdivision
Brain: gray and white matter
Diencephalon
Thalamus
major sensory center and
motor output
Corpus callosum
links 2 hemispheres
Hypothalamus
major center for homeostasis
Thalamus
All senses, except olfaction, are routed through it to cortex
Limbic system
emotion, memory, and learning
Brainstem
midbrain, pons, medulla
Brainstem
Tectum:
Superior colliculus: part of vision
Inferior colliculus: part of audition
Tegmentum:
Reticular Formation:
sleep, arousal, muscle tone
contain norepinephrine nuclei
Substantia Nigra:
motor system (Parkinson’s dis)
contain major dopamine nuclei
Periaqueductal gray area:
contain Substance P nuclei
sensitive to opiates
Periaqueductal gray area
Spinal cord
Blood-brain barrier
endothelial cells (tight junctions in-between),
pericytes, and astrocytes (end-foot processes)
Motor
corticospinal
rubrospinal
reticulospinal
tracts
Motor
multiple
descending
tracts from
brainstem
Spinal Cord
spinal reflex; central pattern generators at C-, L-enlargement
Motor
the motor unit
Motor
extrapyramidal system (basal ganglion)
Functions of Basal ganglion: other than motor control
Sensory
Dermatomes
Somatosensory
spinothalamic tract
Somatosensory
proprioception
dorsal column pathway
Somatosensory
pain modulatory pathways
Autonomic
Autonomic
Hypothalamic nucleus