Transcript Bcl-2
Bcl-2 and its Role in Cancer Mitochondria in the Cell http://micro.magnet.fsu.edu/cells/mitochondria/images/mitochondriafigure1.jpg Cytochrome C’s Dual Functionality Protein that carries electrons in electron transport chain between mitochondrial membranes BUT released into cytosol, triggers apoptosis http://upload.wikimedia.org/wikipedia/commons/thumb/b/ba/Cytochrome_C.png/250pxCytochrome_C.png Bcl-2 family – apoptosis regulators http://www.cancer.gov/cancertopics/understandingcancer/targetedtherapies/lympho ma_htmlcourse/page3 Apoptosis Pathway http://www.reading.ac.uk/nitricoxide/intro/apoptosis/mito2.jpg Stress signal (DNA damage, heat shock) Pro-apoptotic members activated Cytochrome c release via MOMP Cytochrome c complexes with ATP and Apaf-1 (enzyme) Caspase-9 activated, then forms apoptosome with previous complex Caspase cascade to apoptosis Bcl-2 Knockout Mice • Viable, but smaller • Half die by 6 weeks • Smaller kidneys • Skeletal development • Immune failure http://openi.nlm.nih.gov/detailedresult.php?img=2132464_JCB.amling5g&req=4 NonHodgkin Lymphoma https://encryptedtbn3.gstatic.com/images?q=tbn:ANd9GcTkoz4iPsXeDUTi1dbV1wzIQsD8sDB7HqkRJaxih9U4 UWe9Cusd-A Bcl-2 Translocations Found in Cancer http://www.sciencedirect.com/science/article/pii/S0167488903001885 Overexpression of Bcl-2 on the Outer Membrane of Mitochondria http://www.cancer.gov/cancertopics/understandingcancer/targetedtherapies/lymphoma_ htmlcourse/page3 Inhibiting Bcl-2 http://www.cancer.gov/images/targetedtherapies/lymphoma/m4s3c_1.jpg Potential Therapeutic Undergoing Clinical Trials http://www.cancer.gov/PublishedContent/Images/images/targetedtherapies/lymphoma/ m4s3c_3.jpg Sources • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2 132464/ • http://www.scq.ubc.ca/apoptosis/ • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3 220196/pdf/iep_79.pdf • http://www.cancer.gov/cancertopics/understandi ngcancer/targetedtherapies/lymphoma_htmlcou rse • http://www.sciencedirect.com/science/article/pii /S0167488903001885