Introducing DeNDRoN East Anglia

What is DeNDRoN?

What does it do?

What is the evidence it is successful?

Where next?

www.dendron.org.uk

DeNDRoN is a managed network not an organisation

net·work / ‘net 1 wərk/ n. 1. a group or system of interconnected people or organisations www.dendron.org.uk

DeNDRoN

• Aims to: – Support development & delivery of clinical research in dementia & neurodegenerative diseases • By: – Providing leadership & administrative support

to allow the integration of health research & patient care

– Developing capacity & expertise to improve the speed & quality of research www.dendron.org.uk

Through developing a strong network our vision is that...

All patients with a neurodegenerative disease* have the opportunity to participate in and benefit from high quality clinical research *Dementia Parkinson’s Disease Huntington’s Disease Motor Neurone Disease www.dendron.org.uk

The 7 DeNDRoNs

www.dendron.org.uk

East Anglia DeNDRoN

www.dendron.org.uk

Norwich

www.dendron.org.uk

Cambridge

www.dendron.org.uk

What does DeNDRoN do?

• LRN – Provide clinical leadership for research – Assist local researchers to undertake NIHR Portfolio studies – Develop new research sites & investigators – Patient & public involvement – Annual budget £500k / LRN • National – Develop new studies (CSG, writing groups) – Adopt studies onto the NIHR Portfolio – Coordinate the strategic development of neurodegenerative research in England – Promote collaboration between patients, carers, researchers, academics, NHS trusts, funding bodies & industry – Support & guidance to LRNs www.dendron.org.uk

DeNDRoN East Anglia – Strategy

• Support existing research active sites – Financial input & DeNDRoN research staff – Encourage involvement in complex studies • Develop new sites & PIs – Active promotion of DeNDRoN in periphery – Targeting of potential PIs – Acting as “broker” between new sites / PIs & sponsor – DeNDRoN staff involvement throughout study – Facilitation & encouragement of local staff – Deploy DeNDRoN staff locally when research activity justifies it www.dendron.org.uk

What Has DeNDRoN East Anglia Achieved?

• Increased number of: – Studies – Research sites – Principal Investigators – Patients recruited into research • Contributed to development of academic base in East Anglia – Closer working with local academic departments – Development of academic posts in Old Age Psychiatry www.dendron.org.uk

DeNDRoN PIs (2006)

• • 11 Studies 9 Principal investigators – 55% Neurologists – 11% Old Age Psychiatrists – 55% Cambridge-based Public Health OAP Primary Care MFE Neurology 6 4 2 0 Cambridge Norwich Ipswich Peterborough www.dendron.org.uk

Gt Yarmouth

Cumulative DeNDRoN PIs (2006 – 2010)

• 39 Studies • 27 PIs – 41% Neurologists – 37% Old Age Psychiatrists 14 – 48% Cambridge-based 12 10 8 6 4 2 0 Cambridge Norwich Ipswich Peterborough Gt Yarmouth Public Health OAP Primary Care MFE Neurology www.dendron.org.uk

6 5 1 0 4 3 2

New DeNDRoN PIs (2006 – 2010)

• 16 New PIs – 25% Neurologists – 56% Old Age Psychiatrists – 25% Cambridge-based – 75% Outside Cambridge Public Healt h OAP Pr imar y Car e MFE Neur ology Cambridge Norwich Ipswich Peterborough Gt Yarmouth www.dendron.org.uk

www.dendron.org.uk

www.dendron.org.uk

Where Next?

• •

Increase locally-generated studies

– Local Research Directors – – Local Dementia Research Interest Group (HIEC) Local writing groups

Improve recruitment (numbers & speed)

– Development of “Entirely Research Active” demonstration site • Integration of research into local care pathways • Routine invitation at first contact with service to participate in research • Case registers / Recruitment & Facilitation Tools (RAFTs) – – Increase research capacity by developing further sites & PIs Reduce time delays by closer working with CLRNs & NHS R&D departments www.dendron.org.uk

Thanks to the DeNDRoN East Anglia Team

www.dendron.org.uk