Transcript NSCLC Epidemiology

Slides last updated: October 2013
Lung cancer incidence and mortality
Lung cancer is one of
the most common
cancers, with 1.6 million
new cases per year
worldwide1
Lung cancer is the most
common cause of death
from cancer, responsible
for 18.2% of all cancer
deaths1
1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM. GLOBOCAN 2008 v2.0, Cancer Incidence and
Mortality Worldwide: IARC Cancer Base No.10 [Internet]. Lyon, France: International Agency for Research on
Cancer; 2010. Available from: http://globocan.iarc.fr, accessed on 15/09/2013.
Rates of lung cancer incidence and mortality differ worldwide1
Northern America
Central and Eastern Europe
More developed regions
55% of new lung cancer cases
occur in developing countries
Eastern Asia
Micronesia
Western Europe
Polynesia
Highest lung cancer rates are
found in Northern America
Lung cancer is the most common
cancer in men and the second
most common in women
Northern Europe
Southern Europe
Australia/New Zealand
World
South-Eastern Asia
Less developed regions
Caribbean
Southern Africa
Western Asia
South America
Lowest lung cancer rates are
found in Middle Africa
Lung cancer is the 15th most
common cancer
Central America
Incidence
Melanesia
Mortality
Northern Africa
South-Central Asia
Eastern Africa
Western Africa
Male
Female
Middle Africa
80
60
40
20
0
20
40
60
80
Estimated age-standardized rates (World) per 100,000
1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM. GLOBOCAN 2008 v2.0, Cancer Incidence and
Mortality Worldwide: IARC Cancer Base No.10 [Internet]. Lyon, France: International Agency for Research on Cancer;
2010. Available from: http://globocan.iarc.fr, accessed on 15/09/2013.
Rates of lung cancer incidence differ between men and women1
Lung
Breast
Prostate
Cervix uteri
Lung
Colorectum
Colorectum
1092056
948993
Stomach
Lung
Liver
Stomach
Lung
Corpus uteri
Oesophagus
515999
427586
Bladder
Ovary
Non-Hodgkin lymphoma
Liver
Leukaemia
Thyroid
Lip, oral cavity
Leukaemia
Kidney
Non-Hodgkin lymphoma
Pancreas
Oesophagus
Larynx
Pancreas
Brain, nervous system
Brain, nervous system
Other pharynx
40
30
Kidney
20
10
ASR (W) rate per 100,00
0 0
10
20
30
ASR (W) rate per 100,00
40
Incidence
Mortality
Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM. GLOBOCAN 2008 v2.0, Cancer Incidence and Mortality
Worldwide: IARC Cancer Base No.10 [Internet]. Lyon, France: International Agency for Research on Cancer; 2010. Available
from: http://globocan.iarc.fr, accessed on 15/09/2013.
Survival rates for lung cancer are generally low1
Five-year survival trend
PERCENTAGE (%)
100
Breast
cancer
80
Colorectal
cancer
60
40
High unmet medical need
Prostate
cancer
20
Lung
cancer
0
1975
Survival rates vary
depending on stage
at diagnosis. The
later the stage of
diagnosis the
lower the survival
rates tend to be.
2004
1. SEER. Fast Stats Online. 5 year survival by diagnosis. 1975-2004. All races. All ages. Male and Female. Available online:
seer.cancer.gov/faststats/selections.php, accessed on 15/09/2013.
NSCLC makes up approximately 85% of lung cancer1
Large cell carcinoma
(2.6% of lung cancer)
Lung Cancer
(100%)
Other NSCLC
(20.2% of lung cancer)
Squamous cell
carcinoma
(21.4% of lung
cancer)
NSCLC
(85.3% of lung cancer)
Adenocarcinoma
(40.1% of lung
cancer)
1. Howlader N, Noone AM, Krapcho M, et al. (eds). SEER Cancer Statistics Review, 1975-2010, National Cancer Institute.
Bethesda, MD, http://seer.cancer.gov/csr/1975_2010/, based on November 2012 SEER data submission, posted to the SEER
web site, April 2013, accessed on 15/09/2013.
The distribution of NSCLC subtypes is changing1
Since the 1980’s,
squamous cell
carcinomas have
become relatively
less common
Meanwhile,
adenocarcinomas
have become
relatively more
common
The reasons for these changes are unclear,
but may be due to changes in the
composition and filtering of cigarettes
1. Devasa S, Bray F, Vizcaino A, et al. Int. J. Cancer 2005: 117, 294–299