Transcript Fluke-ACL

Liver
Flukes
So who likes liver anyway?
What’s the Problem?
• Fasciola hepatica
• Fascioloides magna
No, the problem is … A+
Are To Often These …
Where’s the problem?
Any place you find
“mud” snails
Closer To Home
We Went On A Field Trip
Look What We Found
Not Only A Lost Liver …
But Lost Liver Function
Fasciola hepatica
Host:
Sheep, cattle, other ruminants (+/- wild)
Intermediate host:
Snails only, Lymnaea spp.
Poorly drained land …Seasonal transmission
Geographic distribution:
Gulf Coast (FL, MS, LA, TX, OK & KS)
Pacific Northwest (WA, OR, CA, ID & MT)
Missouri River Valley
and now Nebraska
Fascioloides magna
Host:
Deer, Elk … cattle
Intermediate host:
Snails only, Fossaria, Lymnaea, Stagnicola.
Poorly drained land …Seasonal transmission
Geographic distribution:
Pacific Northwest Great Lakes region
Gulf States and now Nebraska
Cycle of Fasciola hepatica
Develop to adults
7-8
weeks
Egg
Enter the bile duct
Miracidium
Migrate in parenchyma
Sporocyst
Penetrate liver
Redia
4 - 6 day
Abdominal cavity
Penetrate intestinal wall
1 day
Excyst in duodenum
Cercaria
Metacercaria
What Can You Do About It?
Fasciola hepatica (adults)
•
•
•
Clorsulon (Curatrem - Merial) … also as fixed
combination drug (ivermectin, Ivomec Plus)
Albendazole (Valbazen - Pfizer)
In the feedlot - may recover some liver function loss
Fascioloides magna (adults)
•
•
Clorsulon & Albendazole ???
At 5 X dose neither has been very effective
CAUTION: DON’T BE DECEIVED …
•
•
Research Stats Are Important …
Trial design must be legitimate
Put A Pencil To The Options
Fluke (NatAvg)
2%
ADG-%loss
8% to 30%
FE-%loss
5% to 12%
4.0%
19.0%
9.0%
0.02x0.08=
0.02x0.30=
Average ADG =
IVOMEC =
IVOMEC Plus =
VALBAZEN =
Pour-On =
0.16%
0.60%
0.76%
Plus 0.02x0.05=
Plus 0.02x0.12=
0.10%
0.24%
0.36%
0.46%
Average FE =
0.22%
$0.32/CWT
$0.34/CWT
$0.23/CWT
$0.08/CWT
BE-FlukeEffect
This Can Be A Problem
That’s Hard
To See …
Until You Look
Inside …