Transcript hexbio-clinical-presentation

As A
Biotherapeutic Agent In
Clinical Nutrition

Microbial Cell Preparation

Efficacy Established

Scientifically Proven Safe For Consumption

Palatable Flavour

No Reported Side Effect

Registered With National Pharmaceutical
Control Bureau
IMPROVE
QOL
CLINICAL
NUTRITION
ABSORPTION
& Constipation
Pathophysiology of
Constipation
Bed
Ridden
Patients
Medication
Laxative Abuse
Vulnerable
Groups
Pregnant
Mothers
Aged Population
Premature Babies
Travelling Individual
Stress
Prolonged Constipation
May Lead To:
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Hemorrhoids
Anal fissure
Diarrhea
Fecal incontinence
Rectal bleeding
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Rectal prolapse
Rectal hernia
Fecal impaction
Uterine hernia
Uterine prolapse
www.wrongdiagnosis.com
Prolong Constipation:
Hemorrhoids
Rectal Prolapse
Anal Fissure
Rectal Bleeding
Uterine Prolapse
Hexbio
Improves
Chronic
Constipation
Number of patients according to gender
The study of “Efficacy of
in Improving Chronic Constipation” was conducted in
12 patients consisting of 5 males and 7 females. Figure shows the total of patients (N)
involved in the study according to gender.
Years of constipation
Age of patients
2
31
5
10
15 20 25
30 35 40
45 50 55
60 65 70 75
22
80
85
83
Age of patients and years of constipation
Chart shows the age of the patients ranging from 22 to 83 years old and the years each patients
suffer from constipation ranging from 2 to 31 years.
years
Results
Stool frequency
p = 0.001
Stool frequency per week
Above graph shows the frequency of stools during the study period of 7 days.
According to the results, stool frequency increased from 1.4 time a week before treatment to 4.3 a
week after treatment. This indicates the efficacy of
in increasing patients’ bowel
movement and reduces constipation.
Role of Probiotic Mixture In Treatment Of
Childhood Constipation
4. 2
3.8
2.0
Frequency of Bowel Movement
The probiotic mixture was contained Bifidobacterium and lactobacillus. Frequency of
Bowel Movement (BM) per week in 20 children we tested. According to the chart, the
frequency of BMs in overall children increased in each week showing that the
administration of probiotic mixture had a positive effect on frequency of BM.
The role of probiotics mixture in the treatment of childhood constipation : a pilot study. Noor-L-Huada Bekkali, Marloes EJ Bongers,
Maartje M Van den Berg, Olivia Liem and Marc A Benniga. Netherlands. Published in 4 August 2007.
Prevalence of Irritable Bowel Syndrome on young adult.
Malaysian: A survey among Medical Students
A study to determine the prevalence of IBS and to assess the symptoms subgroups in
young adult Malaysians was done. The results obtained had been categorized into few
subgroups of symptoms as shown above. As conclusion, within the IBS population, the
majority (77.4%) was of the constipation-predominant IBS subgroup.
Prevalence of irritable bowel syndrome in young adult Malaysians: A survey among medical students. Tan, Yan-mei; Goh, Khean
L; Muhidayah, Raja; Ooi, Chee L; Salem, Omar. Department of Medicine, Faculty of Medicine, University of Malaya.
HOW
HELP
CONSTIPATION???
Mechanism
of Action
Provide
Acidic
Environment
Induce
Peristalsis
Increase
Bowel Movement
Frequency
Shorten
Colonic Transit
Time
Facilitate
Smoother
Defecation
 Secretes organic acids, maintaining acidic
environment that induce peristalsis.
 Regularize bowel movement and shortens the
Colonic Transit Time.
Bekkali et. al. (2007). The role of probiotics mixture in the treatment of childhood constipation: a pilot study.
Nutrition Journal 6: 17.
& Diarrhea
Is Like A
Storm Raging
Inside You &
Its Shows Up
At The Most
Unexpected
Time
Diarrhea
Frequent loose or liquid bowel movements, often due
to disruption of water absorption in the colon
Defense Mechanism

In the event of pathogenic infection, diarrhea functions as an evolved expulsion
defense mechanism.

The appendix serves as a safe house for the good bacteria, protecting it from
contamination and facilitating a re-start of the system once the contaminating
organisms has been eliminated.
Types of Diarrhea
Type
Condition
Caused
Efficacy,®
HEXBIO
Secretory
Diarrhea
Increase secretion
activity or inhibition of
absorption.
1.
Cholera toxin
Osmotic
Diarrhea
Too much of water is
drawn into the bowel,
maldigestion.
1.
2.
3.
Osmotic laxatives
Malabsorption
Lactose
intolerance
Selective
Rapid movement of
food through the
intestines
(hypermotility).
1.
2.
Menstruation
Hyperthyroidism
N.A.
Damage to the mucosal
lining, which leads to a
passive loss of proteinrich fluids, and a
decreased ability to
absorb these lost fluids.
1.
Bacterial/ viral/
parasitic infection
Inflammatory
bowel disease
Antibiotic
treatment
Colon cancer
Most
Motility-Related
Diarrhea
Inflammatory
Diarrhea
2.
3.
4.
N.A.
Treatment of Acute Gastroenteritis in Infants
(6-12 months)
From the study, 65 young children aged 6-12 months, suffering from acute gastroenteritis were
treated daily until diarrhea resolution. As showed in the result, the feeding of microbial cell
preparation reduced the severity and duration of acute gastroenteritis in young children.
Raanan Shamir et. al, Evaluation of a diet containing probiotics for the treatment of mild diarrheal
illness in children younger than one year of age, American College of Nutrition 2005; 24(Suppl. 5):370-375
61 children that tested positive for rotavirus were treated with microbial cell
preparation/placebo for 6 days. Stools were collected and examined again after 6 days of
treatment. In conclusion, oral administration of microbial cell preparation is effective in
reducing the duration of rotavirus excretion.
Guarino A et. al, Oral bacterial therapy reduces the duration of symptoms and of viral excretion in children with mild diarrhea,
Department of Pediatrics, University Federico II of Naples, Italy
Reduce Incidence of
Antibiotic Associated Diarrhea
 The largest meta-analysis to evaluate 34 different
clinical trials involving 4844 patients.
 Result:
Reduced the likelihood of developing antibioticassociated diarrhea by 52%.
 Conclusion:
The benefits were most pronounced among
children.
Sazawal S, Hiremath G, Dhingra U, Malik P, Deb S, Black RE. Efficacy of probiotics in prevention of acute diarrhoea:
a meta-analysis of masked, randomized, placebo-controlled trials. Lancet Infect Dis. 2006;6:374-382.
Reduce Incidence of Acute Diarrhea
 An analysis to evaluate 34 different clinical trials
involving 4844 patients.
 Result:
Reduced the incidence of acute diarrhea by 34%.
 Review:
In 12 pediatric studies included in this analysis, it
reduced the likelihood of acute diarrhea in children
by 57% (p<0.001)
 Conclusion:
The benefits were most pronounced among children.
Sazawal S, Hiremath G, Dhingra U, Malik P, Deb S, Black RE. Efficacy of probiotics in prevention of acute diarrhoea:
a meta-analysis of masked, randomized, placebo-controlled trials. Lancet Infect Dis. 2006;6:374-382.
Combined Treatment (with ORS) of
acute diarrhea in children
37 children aged 3 to 24 months received ORS as a form of rehydration, and were treated to microbial cell
preparation at 12-hours interval until the resolution of diarrhea.
In conclusion, addition of microbial cell preparation to ORS was effective in the treatment of children with
acute diarrhea by decreasing the duration of diarrhea.
Simakachorn N. et. al, Clinical evaluation of the addition of lyophilized Lactobacillus LB to oral rehydration
therapy in the treatment of acute diarrhea in children, Journal of Pediatric Gastroenterology and Nutrition 0277-2116
Hexbio® + ORS
Gilliland et. al. (2001). Health and nutritional properties of probiotics
in foods including powder milk with live Lactic Acid Bacteria, WHO/FAO
HOW
HELP
DIARRHEA???
Mechanism
of Action
Produce
anti-microbial
substances
Reduce
rotavirus
shedding
Secretes lactase
enzyme
Neutralize
enterotoxins
from pathogen
Suppress the
replication of
virus
Facilitate
digestion of
lactose
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

Neutralize enterotoxins from pathogens.
Produce anti-microbial substances to
suppress the growth of pathogens.
Reduce rotavirus shedding.
& Immunity
Cold and Flu

Common Cold – upper respiratory
tract infection caused by either
rhinoviruses or coronaviruses.

Flu – infectious disease caused by
Influenza viruses.
HOW
HELP
to induce immunity???
Mechanism
of Action
Immunostimulation
of mucosal
membrane
Increase
Synthesis
of IgA



Increase
T-Lymphocytes
Activate MDC
Induces secretion of Immunoglobin A.
Increase level of T-Lymphocyte cells as well as other
helper immune cells.
Activate the human myeloid dendrite cell (MDC) to
induce immune response.
Stimulation of T-Lymphocyte Level
T-Lymphocyte
Level/10 pilli
140
125
120
90
100
80
60
40
20
0
Treatment Group
Control Group
Consumption of microbial cell preparation able to
stimulate the level of T-Lymphocyte cells.
G. Perdigon et. al, Symposium: Probiotic bacteria for humans:
Clinical systems for evaluation of effectiveness, Journal of Dairy Science 1995 78:1597-1606
Reduction of Cold and Flu Symptoms


For 6 months, 326 children, aged 3 to 5 were
treated twice a day.
Results:
Symptoms
Incidence Rate
Treatment
Group
Control Group
Cough
29.5%
83.7%
Fever
16.1%
63.5%
 Microbial cell preparation reduces the incidence and
severity of cold and flu symptoms in children.
Probiotic Effects on cold and influenza-like symptom incidence and duration in children.
American Academy of Pediatrics
& Other Diseases
STROKE
Chart shows the overall rates of complications in the Asian region. Among the nonneurologic complications, the most commonly encountered were chest infections,
constipation and urinary retention with a rate of 19%, 15% and 11% respectively.
Complication of Acute Stroke : A study in Ten Asian countries. Jose C.Navvaro MD MSc et.al,
Neurology Asia 2008; 13:33-39. University of Santo Thomas, Espana, Manila, Phillipines.
DIABETES
DIABETES
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TYPE 1
TYPE 2
Is a failure
of the pancreas to
produce insulin
Is insulin resistance
or impaired
glucose tolerance
Gastrointestinal Symptoms associated to Diabetic Complications.
Scientist state that 76% of DM patients undergo at least one gastrointestinal
problem and the majority of them suffer from constipation.
The percentage are as shown below:-
Diabetes Related
GIT Symptoms
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Irritable Bowel Syndrome
Constipation
Dyschezia (Painful Defecation)
Diarrhea
Fecal incontinence
Dyspepsia
(Upset Stomach, Indigestion)
• Nausea /vomiting
• Heartburn
The chart pie above shows the prevalence of GI tract symptoms among patients
with DM type 1 compared to respective control. As showed above, the highest
symptom stand of peripheral neuropathy for muscle numbness, continued by
dyspepsia and constipation which holds the third place with percentage of 16.7%.
The chart pie above shows the prevalence of GI tract symptoms among patients
with DM type 2 compared to respective control. As showed above, the highest
symptom is peripheral neuropathy with 51.6%, continued by heartburn 19.8%,
dyspepsia 13.4% and constipation 10.1%.
COLON CANCER
Evaluation Of Stool
DEFECATION..
Is not evaluated
according to
HOW MANY times
we defecate..
It is evaluated
according to the
TYPES of stool that
been eliminated..
Types of Stool
Bristol Stool Chart
Constipation
Normal
Diarrhea
Bowel Movement (BM) Frequency and Risk of Colorectal Cancer in a Large
Cohort Study of Japanese Men and Women
IRR
BM
Above chart shows the average Incidence Rate Ratios (IRR) for colorectal and colon cancer according
to BM frequency. As shown, it is the best to have BM every 2-3 days as it shows the lowest IRR. Too
often of BM per day can cause higher risk of colon and colorectal cancer. This is the same with BM
every 6 days or less which has IRR of 1.81 average for both men and women.
British Journal of Cancer (2004) 90, 1397-1401
Colon Cancer
Safety
 Acute Oral Toxicity Test for Hexbio was done in TÜV SÜD
PSB Singapore to find out the Adverse Effect of Hexbio.
 Necropsy Result shows there is no weight & colour change
of the liver.
Nutrition Fact
Content
Unit
Protein
gram per sachet
0.16
Fat
gram per sachet
0
Fiber
gram per sachet
0
Carbohydrate
gram per sachet
2.7
Calories
gram per sachet
11.6
* Hexbio® is safe for all type of patients’ consumption
since the Carbohydrate and the Calories are in the
safe range for everybody
Hexbio In Balancing QOL
Sleeping
Psychology
Activity
Appetite
When there is Constipation; Diarrhea; Cold or Flu
Our normal daily activities (as mentioned) will be disturbed.
Hexbio is here to overcome the symptoms and improve the Quality of Life!
HOW TO USE ?
WHEN TO USE ?
Hexbio can function at BOTH
small intestine & large intestine
Consume:
1 sachet during each meal
• Breakfast
• Dinner
As a good treatment;
For good absorption of nutrients;
and for faster recovery
Dosage
1. Oral Dose
Consume 2 sachets during Breakfast & Dinner each
by directly pour into the mouth
2. Liquid Dose
1 sachet (3g) to 5ml water/juices/energy drinks/milk
Pour 1 sachet
into 5ml water
Stir to mix
Feed using
syringe
Thank You!
B-CROBES MARKETING (M) SDN. BHD.