Transcript Untitled - Ibsa Farmaceutici Italia

FLORENCE, Italy
2017
March 23 - 26
SCIENTIFIC INFORMATION
Congress Chairmen
Jean-Yves REGINSTER
ESCEO President
John A. KANIS
IOF President
Programme Committee
Cyrus COOPER
Chair, IOF Committee Scientific Advisors (CSA)
René RIZZOLI
Chair, ESCEO Scientific Advisory Board (SAB)
John A. KANIS
IOF President
Jean-Yves REGINSTER
ESCEO President
Honorary Local Organizing
Committee
Maria-Luisa BRANDI (chairperson)
Giovanni CORSELLO
Claudio CRICELLI
Margherita DE BAC
Raniero GUERRA
Giovanni IOLASCON
Andrea LENZI
Stefania MAGGI
Marcella MARLETTA
Alberto MIGLIORE
Dario NARDELLA
Ranuccio NUTI
Ignazio Benedetto OLIVIERI
Sergio ORTOLANI
Giuseppe SESSA
Umberto TARANTINO
Umberto VERONESI
WCO-IOF-ESCEO 2017 - FLORENCE, ITALY - PROGRAMME
ESCEO Scientific Advisory Board
and Abstracts Reviewers
D. AGNUSDEI
K. AKESSON
N. ARDEN
J. BAUER
I. BAUTMANS
C. BEAUDART
J.-J. BODY
A. BORG
M. BOUXSEIN
M.-L. BRANDI
O. BRUYÈRE
F. BUCKINX
N. BURLET
E. CAVALIER
M. CESARI
T. CHEVALLEY
C. CHRISTIANSEN
J. COMPSTON
C. COOPER
B. CORTET
A. CRUZ-JENTOFT
E. CZERWINSKI
E. DENNISON
J.-P. DEVOGELAER
M. EDWARDS
S. FERRARI
A. GASPARIK
N. HARVEY
M. HILIGSMANN
H. JOHANSSON
J. A. KANIS
J.-M. KAUFMAN
F. LANDI
P. LIPS
R. LORENC
G. LYRITIS
S. MAGGI
J. MARTEL-PELLETIER
E. McCLOSKEY
J. PACCOU
S. PAPAPOULOS
K. PAVELKA
J.-P. PELLETIER
D. PINTO
D. PRIETO-ALHAMBRA
J.-Y. REGINSTER
J. RINGE
R. RIZZOLI
Y. ROLLAND
C. ROUX
P. SZULC
T. THOMAS
B. VELLAS
4
WCO-­‐IOF-­‐ESCEO 2017 CONGRESS -­‐ Florence, Italy Event Title: World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases
Venue:
Florence, Italy
Date: March 23-26, 2017
Main language: English
Short description:
IOF and ESCEO have worked in partnership for several years to develop a unique European
springtime meeting programme for healthcare professionals, researchers and young scientists.
With over 3,800 participants, this has become the largest educational event and most vibrant
clinical research forum for osteoporosis and osteoarthritis in Europe.
Nature of the event:
The common aim of this event is to gather new knowledge, skills and tools in the prevention
and treatment of osteoporosis, osteoarthritis and musculoskeletal diseases. The aim of this
congress is to move the field one step forward on all fronts; from new understanding of bone
metabolism and pathology, to new strategies and option in prevention, diagnosis and
treatment.
Duration of the event:
2x15min Opening Lecture, 1x30min Opening Honorary lecture, 1x 1h45 Special session
Lecture, 1x 1hour Honorary Lecture, 3x 1hour Educational Lecture, 10x 30min Plenary
Lecture, 7x 1hour Oral Communication from selected abstracts, 7x 1hour Symposium, 9x
1hour Meet-The-Experts sessions, 2x 1hour Poster Viewing, 2x 1hour Posters Oral
Presentation, 7x 1h30 Industry Symposia
Total hour of the event: 22h 30min
Target Audience:
We expected 3800 participants from all over the world. The specialities of the doctors,
professors, researchers are: Rheumatologist, epidemiologist, orthopaedics, geriatrics, internal
medicine, metabolic bone diseases, endocrinologist.
Educational needs and outcomes:
The event is dedicated to a close interaction between clinical scientists dealing with rheumatic
disorders, pharmaceutical industry developing new compounds in this field, regulators
responsible for the registration of such drugs and health policy markers, to integrate the
management of osteoporosis and osteoarthritis within the latest clinical and economic
information. This allows them to organize their daily practice in an evidence-based medicine
perspective with a cost-conscious perception.
Promotion of active learning and learner engagement:
A certificate of CME activity is issued only upon return of a completed evaluation form to the
registration desk before the participant departure.
Means for feedback of learners: The attendees are required to complete an evaluation form of the congress.
Sources of all funding:
A sponsorship opportunities brochure is send to industries.
17.30 - 19.40
WCO-IOF-ESCEO - OPENING CEREMONY
Chairpersons: John A. Kanis, Jean‑Yves Reginster
17.30
Best clinical papers published in 2016
René Rizzoli
18.30
Opening of the meeting
Maria Luisa Brandi
18.35
WHO's new approach to Healthy Ageing and its implications for research
and clinical practice
John R. Beard (Director of the Department of Ageing and Life Course, World Health Organization – Geneva)
18.55
Baseline stratification of patients on the basis of frailty, and the CHMP
pilot on geriatric assessment
Francesca Cerreta (European Medicines Agency – London)
19.10
HONORARY LECTURE
‣ Between Tradition and Innovation of the Officina Profumo Farmaceutica di
Santa Maria Novella from 1612 to today
Eugenio Alphandery (President Officina Profumo Farmaceutica di Santa Maria Novella – Florence)
19.40 - 20.40
INDUSTRY-SPONSORED WELCOME COCKTAIL
5
14.00 - 15.00
MEET-THE-EXPERT SESSIONS
‣ Diabetes and bone
Serge Ferrari
‣ What can we expect from biomarkers in
osteoarthritis?
Gabriel Herrero‑Beaumont
08.00 - 09.00
EDUCATIONAL LECTURE (supported by an
Educational Grant from Bruno Farmaceutici)
‣ Calcifediol: Perspectives for Clinical Applications in
2017
Chairperson: Maria Luisa Brandi
‣ Introduction Maria Luisa Brandi
‣ Control of Mineral Metabolism: the ADDID Study
Salvatore Minisola
‣ Comparison of in vivo Function of Calcifediol vs.
Cholecalciferol Heike A. Bischoff‑Ferrari
‣ General Discussion
‣ Conclusions Maria Luisa Brandi
09.00 - 12.00
SCIENTIFIC SESSION I
Chairpersons: John A. Kanis, Jean‑Yves Reginster
09.00
Plenary Lecture 1
‣ Who and when to treat in osteoporosis? John A. Kanis
‣ Osteoporosis before menopause
Ego Seeman
14.00 - 15.00
WHO SYMPOSIUM
Integrated Care for Older People (launch of the
ICOPE Guidelines)
Chairpersons: Roger Fielding, John Beard
‣ Introduction
‣ Community care model for optimizing trajectories
of intrinsic capacity Islene Araujo de Carvalho
‣ Screening for declines in intrinsic capacity in older
people: a personalized approach to promote
healthy ageing Matteo Cesari
‣ Role of nutrition and physical exercise in
maintaining intrinsic capacity Olivier Bruyère
‣ Closing the evidence to practice gap: WHO ICOPE
guideline recommendations
Jotheeswaran Amuthavalli Thiyagarajan
‣ Discussion
10.30
Plenary Lecture 2
‣ What can we expect from bone forming agents in
the management of osteoporosis? Serge Ferrari
14.00 - 15.00
HONORARY LECTURE
IL-17 in bone, cartilage and muscle diseases : State of
the art and practical consequences for the patient
Pierre Miossec
14.00 - 15.00
ESCEO SYMPOSIUM
Identification and management of patients at
imminent risk of osteoporotic fracture
Chairpersons: Bernard Cortet, Bo Abrahamsen
‣ Welcome and scope of the problem Cyrus Cooper
‣ How can we define a patient at imminent risk of
fracture? Nicholas Harvey
‣ Efficacy of currently available treatments in
patients at imminent risk of fracture Thierry Thomas
‣ Discussion : Leader: Salvatore Minisola
‣ Wrap-up and conclusion Cyrus Cooper
Panel: Bo Abrahamsen, Maria Luisa Brandi, Jorge Cannata Andia,
Cyrus Cooper, Bernard Cortet, Hans Peter Dimai, Serge Ferrari,
Peyman Hadji, Nicholas Harvey, John A. Kanis, Marius Kraenzlin,
Andreas Kurth, Andrea Laslop, Eugene McCloskey,
Salvatore Minisola, Jean‑Yves Reginster, René Rizzoli,
Thierry Thomas
6
15.00 - 17.00
SCIENTIFIC SESSION II
Chairpersons: Cyrus Cooper, René Rizzoli
15.00
Plenary Lecture 3
‣ Implication of bone biomechanics in daily practice
Mary L. Bouxsein
16.30
Plenary Lecture 4
‣ Emerging treatments for the management of
osteoarthritis Tim McAlindon
17.00 - 18.30
IINDUSTRY--SPONSORED SATELLITE SYMPOSIUM: IBSA Satellite Symposium
Time to improve the management of osteoarthritis: let us forget the old stereotypes?
Chairpersons: Jean-Yves Reginster, BE and Marc Hochberg, US
Welcome and introduction
(Marc Hochberg, US)
Advanced knee osteoarthritis: surgical versus pharmacological treatment? (Lee Simon, US)
Osteoarthritis-related increase in all-cause mortality: implications for pharmacological
management
(Cyrus Cooper, UK)
Daily management of knee osteoarthritis: from the ESCEO algorithm to the CONCEPT study
(Jean-Yves Reginster, BE)
Discussion and conclusion
(Jean-Yves Reginster, BE)
7
08.00 - 09.00
14.00 - 15.00
NON-SPONSORED SYMPOSIA
MEET-THE-EXPERT SESSIONS
08.00 - 09.00
EDUCATIONAL LECTURE
‣ Patient-reported outcomes : is this the future for
the development of treatments in musculoskeletal
diseases
Maarten Boers
‣ Rare bone disease: approaches to classification
Kassim Javaid
‣ Management of corticosteroid-induced
osteoporosis
Jonathan D. Adachi
‣ Connected devices in musculo-skeletal health
Olivier Bruyère
08.00 - 09.00
ESCEO-WHO SYMPOSIUM
Does nutrition play a role in the prevention and
management of sarcopenia?
Chairpersons: Ivan Bautmans, Roger Fielding
‣ Welcome and scope of the meeting Matteo Cesari
‣ Role of proteins Luc J. C. van Loon
‣ Role of calcium, dairy products and vitamin D
Heike A. Bischoff‑Ferrari
‣ Role of other nutrients Yves Rolland
‣ Discussion - Leader: Marjolein Visser
‣ Wrap-up Roger Fielding
Panel: Sophie Allepaerts, Nasser Al‑Daghri,
Jotheeswaran Amuthavalli Thiyagarajan, Islene Araujo de Carvalho,
Jurgen Bauer, Ivan Bautmans, John Beard, Heike A. Bischoff‑Ferrari,
Maria Luisa Brandi, Olivier Bruyère, Tommy Cederholm,
Francesca Cerreta, Matteo Cesari, Antonio Cherubini, Cyrus Cooper,
Alfonso Cruz Jentoft, Bess Dawson‑Hughes, Roger Fielding,
John A. Kanis, Jean‑Marc Kaufman, Francesco Landi,
Andrea Laslop, Alessandro Laviano, Stefania Maggi,
Vincenzo Malafarina, Eugene McCloskey, Jean Petermans,
Jean‑Yves Reginster, René Rizzoli, Sian Robinson, Yves Rolland,
Ronenn Roubenoff, Ricardo Rueda, Luc J. C. van Loon, Bruno Vellas,
Marjolein Visser
09.00 - 12.00
SCIENTIFIC SESSION III
Chairpersons: Eugene McCloskey, Olivier Bruyère
09.00
Plenary Lecture 5
‣ Can we improve bone health through nutrition?
Cyrus Cooper
10.30
Plenary Lecture 6
‣ Calcium and Vitamin D : the true story
Bess Dawson‑Hughes
14.00 - 15.00
ESCEO SYMPOSIA
ESCEO Working Group: Regulatory aspects of
Rheumatoid Arthritis, in Europe, in 2017
Chairpersons: Maarten Boers, Pierre Miossec
‣ Welcome and introduction Jean‑Yves Reginster
‣ New EMA guidelines on clinical investigation of
medicinal products for the treatment of RA
Pierre Miossec
‣ ESCEO consensus advice to EMA regarding the
guidelines Maarten Boers
‣ Discussion
‣ Conclusion Maarten Boers
Panel: Maarten Boers, Pierre Miossec, Thierry Thomas,
Chris Edwards, Jean‑Yves Reginster
Recommendations for the appropriate use of
Hyaluronic Acid in the daily management of
osteoarthritis
Chairpersons: Cyrus Cooper, François Rannou
‣ Welcome and scope of the problem Cyrus Cooper
‣ Mode of action of Hyaluronic Acid in osteoarthritis
Gabriel Herrero‑Beaumont
‣ Recommendations for the appropriate use of
Hyaluronic Acid in daily management of
osteoarthritis Tim McAlindon
‣ Discussion - Leader François Rannou
‣ Wrap-up and conclusion Cyrus Cooper
Panel: Roy D. Altman, Olivier Bruyère, Cyrus Cooper,
Gabriel Herrero‑Beaumont, Tim McAlindon, Alberto Migliore,
Karel Pavelka, François Rannou, Jean‑Yves Reginster,
Pascal Richette, Daniel Uebelhart
8
14.00 - 15.00
ESCEO-FIRMO SYMPOSIUM
The Research Agenda on Non-classical Actions
of Cholecalciferol
Chairpersons: Maria Luisa Brandi, Maurizio Cutolo
‣ Introduction and Scope of the Problem
Maria Luisa Brandi
‣ Actions of Cholecalciferol on Cardiovascular and
Immune Functions Heike A. Bischoff‑Ferrari
‣ The Role of Cholecalciferol on Malignancy
Francesco Bertoldo
‣ Discussion - Leader Maria Luisa Brandi
‣ Conclusion and Wrap-up Maurizio Cutolo
Panel: Francesco Bertoldo, Heike A. Bischoff‑Ferrari,
Maria Luisa Brandi, Olivier Bruyère, Cyrus Cooper, Maurizio Cutolo,
John A. Kanis, Jean‑Marc Kaufman, Jean‑Yves Reginster,
René Rizzoli
15.00 - 16.45
COMMITTEE OF NATIONAL SOCIETIES
SPECIAL PLENARY SESSION
15.00 - 17.00
SCIENTIFIC SESSION IV
Chairpersons: Bess Dawson‑Hughes, Stefania Maggi
15.00
Plenary Lecture 7
‣ New perspectives in the treatment of frailty and
sarcopenia Bruno Vellas
16.30
Plenary Lecture 8
‣ What do genetics studies bring to the
understanding of osteoporosis? Maria Luisa Brandi
9
08.00 - 09.00
ESCEO-WHO SYMPOSIUM
Pitfalls in the measurement of Lean Body
Mass: a need for consensus and
standardization
Chairpersons: John Beard, Bruno Vellas
‣ Welcome and scope of the meeting John A. Kanis
‣ Why do we need standardization of Appendicular
Lean Body Mass (ALBM) Assessment? Marjolein Visser
‣ How can we achieve standardization of
Appendicular Lean Body Mass (ALBM)
Assessment? Klaus Engelke
‣ Discussion - Leader Francesco Landi
Panel: Nasser Al‑Daghri, Sophie Allepaerts,
Jotheeswaran Amuthavalli Thiyagarajan, Islene Araujo de Carvalho,
Jurgen Bauer, Ivan Bautmans, John Beard, Maria Luisa Brandi,
Olivier Bruyère, Fanny Buckinx, Tommy Cederholm,
Francesca Cerreta, Matteo Cesari, Antonio Cherubini, Cyrus Cooper,
Alfonso Cruz Jentoft, Bess Dawson‑Hughes, Elaine M. Dennison,
Klaus Engelke, Roger Fielding, John A. Kanis, Jean‑Marc Kaufman,
Francesco Landi, Andrea Laslop, Stefania Maggi, Eugene McCloskey,
Jean Petermans, Jean‑Yves Reginster, René Rizzoli, Sian Robinson,
Yves Rolland, Ronenn Roubenoff, Ricardo Rueda, Bruno Vellas,
Marjolein Visser
09.00 - 10.00
EDUCATIONAL LECTURE
‣ Does bone microstructure matter?
Ego Seeman
09.00 - 10.00
MEET-THE-EXPERT SESSIONS
‣ Rare bone disease: novel treatment approaches
Maria Luisa Brandi
‣ Assessment of frailty and sarcopenia in daily
practice
Stefania Maggi
‣ Management of osteoporosis in males
Jean‑Marc Kaufman
10.00 - 12.00
SCIENTIFIC SESSION V
Chairpersons: Maria Luisa Brandi, Nicholas Harvey
10.00
Plenary Lecture 9
‣ Is it a time when stopping osteoporosis treatment
Eugene McCloskey
11.30
Plenary Lecture 10
‣ Can we reduce falls and fractures? René Rizzoli
10
Bo
Rick
Eugenio
Jotheeswaran
Islene
Ivan
John
Francesco
Heike
Maarten
Mary
Maria-­‐Luisa
Olivier
Francesca
Matteo
Cyrus
Bernard
Maurizio
Bess
Klaus
Serge
Roger
Nick
Gabriel
Kassim
John
Jean-­‐Marc
Francesco
Tim
Stefania
Eugène
Pierre
Salvatore François
Abrahamsen
Adachi
Alphandery
Amuthavalli Thiyagarajan
Araujo de Carvalho
Bautmans
Beard
Bertoldo
Bischoff-­‐Ferrari
Boers
Bouxsein
Brandi
Bruyere
Cerreta
Cesari
Cooper
Cortet
Cutolo
Dawson-­‐Hughes
Engelke
Ferrari
Fielding
Harvey
Herrero-­‐Beaumont
Javaid
Kanis
Kaufman
Landi
McAlindon
Maggi
McCloskey
Miossec
Minisola
Rannou
Professor
Professor
Professor
Professor
Professor
Professor
Professor
Jean-­‐Yves
René
Yves
Ego
Luc
Bruno
Marjolein
Reginster
Rizzoli
Rolland
Seeman
Van Loon
Vellas
Visser
Holbæk Hospital -­‐ Institute of Clinical Research, SDU
Department of Medecine
McMaster University
Michael DeGroote School of Medicine
Department of Medecine
Officina Profumo Farmaceutica di Santa Maria Novella
World Health Organization
Ageing and Life Course World Health Organization
Ageing and Life Course Vrije Brussel University
Frailty in Ageing research (FRIA)
World Health Organization
Department of Ageing and Life of Epidemiology Biostatistics
responsabile struttura funzionale: Matattie del Metabolismo Scheletrico e Minerale /Dipartimento
-­‐Department di Scienze
Biomedicheaend Chirurgiche
Klinikdirektorin, Klinik für Geriatrie, UniversitätsSpital Zürich
Geriatry
VU Medical Center,
Department of Epidemiology and Biostatistics
Department of Hematology
Harvard Medical School
Department of Endocrinology
University of Florence
Department
of Epidemiology
University of Liege
Department of Endocrinology
European Medicines Agency
University of Toulouse III Paul Sabatier
Gerontopole
Head of epidemiology department
University of Southampton
CHU Lille
Department of Epidemiology
Department of Orthopaedy
Dipartiment di Medicina Interna e Specialita Mediche
Gerontopole
University of Tufts
University of Erlangen
Institute of Medical Physics
University Hospital of Geneve
Department of Medecine
University of Tufts
Nutrition, Exercise Physiology and Sarcopenia
MRC Lifecourse Epidemiology Unit -­‐ University of Southampton -­‐ Southampton General Hospital
Epidemiology
Rheumatology
HOSPITAL FUNDACION JIMENEZ DIAZ NDORMS University of Oxford
Department of Epidemiology
IOF
Department of Geriatry
University of Ghent
Department of internal medic Ghent
Geriatry
Catholic University of Rome
Tufts University
Rheumatology
National Research Council of Italy
Aging Branch
University of Sheffield
Academic Unit of Bone Metabolic
University of Lyon
Immunologie clinique et rhumatologie Sapienza Università di Roma
UOC Medicina Interna e Malattie Metaboliche dell'Osso
Hopitaux Universitaire, Paris -­‐ Cochin, Broca, Hotel-­‐Dieu
Service de Rééducation et de réadaptation de l'appareil locomoteur et des pathologies dau nd rachis
University of Liege
Public health health economics
University Hospital of Geneve
University Hospital Purpan
University of Melbourne
Maastricht University Medical Centre+
CHU de Toulouse VU University of Amsterdam
Bone diseases
Internal medicine
Medicine and endocrinology
Department of Human Biology and Movement Sciences
Internal medicine
Health sciences
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Hematologist Gerontologist
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Epidemiologist
Endocrinologist
Researcher in geriatry
Epidemiologist
Epidemiologist
Orthopaedics
Geriatrics
Orthopaedics
Internist
Nutritionist
Rheumatologist
Rheumatologist
Epidemiologist
Geriatrist
Endocrinologist
Geriatrist
Rheumatologist
Geriatristr
Orthopaedics
Rheumatologist
Hematologist
Rheumatologist
Holbæk
Hamilton
Florence
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Geneve
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Geneve
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diseases
Liege
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idemiology
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Epidemiologist
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Biologist
Internist
Geriatrist
Liege
Geneve
Toulouse
Melbourne
Maastricht
Toulouse
Amsterdam
Belgium
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France
Australia
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France
The Netherlands