Transcript K-ADNI
KOREAN ADNI … WHERE ARE WE NOW Seol-Heui Han, MD, PhD. On behalf of Preparatory Committee for K-ADNI Clinical Research Center for Dementia of South Korea (CREDOS) 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 9yr Project 700,000 US dollars /yr Funded by the Ministry of Health, Welfare, and Family Affairs Primary focus of CREDOS Healthy, SMI aMCI Cognition AD svMCI SVaD Time CREDOS CREDOS protocols Items for history Neuropsychological tests Cognition ADL Behaviors Differential diagnoses Scales or questionnaires Korean Dementia Screening Questionnaire (K-DSQ) Barthel- index Instrumental ADL (Seoul IADL) NPI MMSE CDR GDS Hachinski ischemic scale Geriatric depression scale Lab Vitamin B12 Folate VDRL TSH/free T4 MRI Axial T2, T1, FLAIR, (GRE) Coronal T1 CREDOS D-Matrix Healthy, SMI WMH on MRI minimal moderate severe No cognitive impairment I-1 I-2 I-3 Mild cognitive impairment II-1 II-2 II-3 Mild to moderate dementia III-1 III-2 III-3 Severe dementia IV-1 IV-2 IV-3 aMCI, AD svMCI, SIVD C O G N I T I O N DESIGNING K-ADNI K-ADNI: Organization Tree CREDOS PI:DL Na Advisory board ADNI: M. Weiner K-ADNI PI: SH Han Assistant administrator: SY Kim , DW Yang Clinical Core Biological Core Stroke risk ADAS-Cog, CDR ADL,NPI, FBI Neurologic scale CSF tau, amyloid Apo E, GWAS Lipid, homocysteine, TFT Imaging Core MRI-VBM, DTI, fMRI FDG-PET, PIB-PET Biostatistics Core Main aim: Effects of SVD on Progression of AD Cognition Time Plan: 500 cases WMH on MRI Cognition mild moderate severe No cognitive impairment 100 0 0 Mild cognitive impairment 100 50 50 Mild to moderate dementia 100 50 50 0 0 0 Severe dementia K-ADNI 5yr Longitudinal study 2010 2011 Recruitment N=500 NPT Biomarker Imaging NPT Biomarker Imaging 2012 2013 2014 2015 Follow up NPT Biomarker Imaging NPT Biomarker Imaging Neuropsychological Tests SNSB, ADL,CGA-NPI, FBI Biomarker Blood: Apo E polymorphism, Genome-wide study CSF Imaging studies MRI PET: FDG-PET, PIB-PET NPT Biomarker Imaging NPT Biomarker Imaging Ready to go Funding sources ($1.5 M/yr for 5 years) Government Private donations Industry support