Transcript lectSides07.ppt

1 mV
Barbiturates
Benzodiazepines
Alcohol
General Anesthetics
familial startle syndrome
Chem.
driving
force
Elec.
driving
force
Rasmussen’s Encephalatis
AMPA Receptor
Kainate Receptor
+
Vc
Glutamate receptor excitatory
postsynaptic currents (EPSCs)
Presynaptic
glutamatergic Neuron
Postsynaptic Neuron
Vm = -35 mV
NMDAR EPSC
AMPAR EPSC
Vm = -70 mV
NMDAR EPSC
AMPAR EPSC
Hippocampal long-term potentiation
ionotropic receptors
metabotropic receptors
Effector
Ionotropic receptor
synaptic actions
Direct
fast (ms)
open synaptic channels
channels only at synapse
excite or inhibit AP
Metabotropic receptor
synaptic actions
Indirect
slower (0.1-100 s)
open or close channels
resting channels,
voltage-gated channels,
fast synaptic channels
modulate excitability
ACh
closure
PIP2
Gq
IP3 DAG
Ca release
Protein kinase C
1. Decrease in resting
outward K current
1. Slow EPSP
1.5
nA
2. Decrease in slow
delayed rectifier K
current
0