Transcript Mark Beggs Presentation

Stratified Medicine Scotland
Mark Beggs Chief Executive
SMS Making a Reality of Stratified Medicine
SMS Making a Reality of Stratified Medicine
Drug Development “Funnel”
Source: PhRMA industry profile 2011
SMS Making a Reality of Stratified Medicine
Sept 24 2015
MVLS Industry Day
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Managing chronic disease - from
empiricism to stratification
Treatment A


Treatment B
Treatment C

Treatment A Treatment B Treatment C
Empirical prescription of drugs, patients are
iterated through available pharmacopeia until
effective treatment is identified
Using patient genetic sequence & phenotype
data and comparing to known correlations the
right drug is prescribed first time
Adapted from Vaidyanathan,
SMS
a Reality of Stratified Medicine
CellMaking
2012;148:1079
Sept 24 2015
MVLS Industry Day
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Stratified Medicine Scotland-Innovation Centre:
The Vision
• Key role of Scotland
• Building the Stratified
Medicine Initiative
•
“To transform the management of chronic disease
by accelerating biomedical research, high quality
healthcare provision and economic growth”
•
“…creating a global leadership position in
Stratified Medicine for Scotland through and
innovative NHS/academic/industrial partnership”
•
“…state of the art scalable whole genome
sequencing and linkage to biomedical
data assets and bioinformatics across the journey
of care for individual patients”
SMS Making a Reality of Stratified Medicine
Sept 24 2015
(Prof. Anna Dominiczak & Prof. Andrew
Morris , 2013 )
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Why Scotland for Stratified Medicine?
• A “Goldilocks” Population for Stratified Medicine ?
– 5.3 million, genetically diverse and geographically static
– significant representation of major diseases & contributory factors
– industrial heritage
– smoking, alcohol, lifestyle
• Unique partner in NHS Scotland
- almost universal coverage (little private sector)
- unifying identifier (CHI number) linkage invented in 1970’s and implemented over
the next decade into general practice
- comprehensive e-health records
- massive longitudinal depth
- can be linked with many decades of electronic and paper records
• Preparedness of patients to engage
SMS Making a Reality of Stratified Medicine
Sept 24 2015
MVLS Industry Day
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Stratified Medicine Scotland-Innovation Centre:
Implementation
SMS Making a Reality of Stratified Medicine
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PGM
Proton
Ion Torrent 318 chip
– 11M wells (PGM)
Wells across surface
of flow cell
Ion Torrent PI chip –
165M wells (Proton)
SMS Making a Reality of Stratified Medicine
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• dNTPs flowed across the surface of the at a rate of 1 every 15 sec
• dNTP flows interspersed with wash steps
• Flow order: ‘TACGTACGTCTGAGCATCGATCGATGTACAGC…repeat’
T C A G
………........
A Adapter
Key Seq
Sequence of Interest
ISP
P1 Adapter
SMS Making a Reality of Stratified Medicine
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• height of the bar indicates how many nucleotides were
incorporated during each flow
SMS Making a Reality of Stratified Medicine
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Stratified Medicine Scotland-Innovation Centre:
Key Milestones
Jan 2015
Clinical projects
underway
July 2014
Dec 2014
Sequencing
protocols signed off
Team onboarded
May 2014
High Performance Computing
operational
March 2014
Custom-built
facility on
ThermoFisher
site
Sept 2013
COO engaged, now CEO
SMS Making a Reality of Stratified Medicine
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MVLS Industry Day
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Permanent Home 2015:
Queen Elizabeth University Hospital, Glasgow
SMS Making a Reality of Stratified Medicine
Sept 24 2015
MVLS Industry Day
Stratified Medicine Scotland-Innovation Centre:
“Exemplar Projects”
Proof of Concept through real healthcare projects
5 disease/study areas represented
well by significant Scottish
populations:
• rheumatoid arthritis
• oesophageal cancer
• ovarian cancer
• COPD/irritable bowel
• multiple sclerosis
Proving out SMS-IC capabilities in:
• project management
• gene sequencing
• large scale data processing
• integration with
healthcare data
SMS Making a Reality of Stratified Medicine
Sept 24 2015
MVLS Industry Day
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Stratified Medicine Scotland- Projects
These Projects Demonstrate SMS-IC Delivery :
1.
2.
3.
4.
5.
Recruiting new disease patient cohorts in real time
Managing large-scale, multidisciplinary project across NHS Scotland,
Universities, Industry partners, Illumina and Ion Torrent sequencing
labs
Accessing patient clinical data directly out of NHS
Answering important questions fundamental to current clinical
treatment of disease
Partnering with commercial organisations both as client and service
provider
SMS Making a Reality of Stratified Medicine
Sept 24 2015
MVLS Industry Day
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Predicting disease activity in people with
newly diagnosed MS based on baseline
clinical, imaging, and genetic profiles
SMS Making a Reality of Stratified Medicine
Stratified Medicine Scotland
Contact us : [email protected]
Website: www.stratmed.co.uk
Can SMS-IC support your development plans ?
Questions?
SMS Making a Reality of Stratified Medicine
Sept 24 2015
MVLS Industry Day
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