Transcript Module 2 - HPV vaccine attributes and storage conditions pptx, 2.86Mb

Essential Training Package for HPV Vaccine Introduction
Module 2
HPV vaccine attributes and
storage conditions
CervarixTM
Learning objectives
 At the end of the module, you will have learned to:
-
Describe HPV vaccine characteristics (CervarixTM)
Discuss the presentation of HPV vaccine
Apply vaccine cold chain requirements
Describe proper handling of 2-dose vial CervarixTM
Vaccine
 Duration
– 25’
2 | HPV vaccine attributes and storage conditions,
Module 2 CervarixTM | 24 July 2016
Key issues
What is HPV vaccine, CervarixTM,
1 presentation?
2 How effective is the vaccine?
3 How safe is the vaccine?
4 At which temperature should the
vaccine be stored?
Where in the refrigerator should
5 HPV vaccines be stored?
What is the proper handling of 2-
6 dose vial CervarixTM vaccine?
3 | HPV vaccine attributes and storage conditions,
Module 2 CervarixTM | 24 July 2016
What is the presentation of CervarixTM?
 CervarixTM is available in a liquid formulation:
 as single dose vial and 2-dose vial, both
preservative-free
 Single dose vial has 0.5mL suspension
 2-dose vial has 1.0mL suspension
 Each vial contains a Vaccine Vial Monitor (VVM)
 Vaccine vials are available in pack sizes of 1, 10, and 100
4 | HPV vaccine attributes and storage conditions,
Module 2 CervarixTM | 24 July 2016
Is CervarixTM effective?
 CervarixTM is a bivalent vaccine to prevent:
– Infection due to HPV types 16 & 18 that cause the majority of
cervical cancers
 High efficacy of CervarixTM against persistent infection with
HPV types has been demonstrated in females
 There is no evidence of waning immunity
5 | HPV vaccine attributes and storage conditions,
Module 2 CervarixTM | 24 July 2016
Is CervarixTM safe?
 CervarixTM is well-tolerated with no major safety concerns
 Injection site reactions such as redness, pain and
swelling can occur
 Mild adverse events include fever, dizziness and nausea
 Syncope can occur after any medical procedure and is
not uncommon in adolescents following receipt of a
vaccine.
 It is recommended that adolescents be seated during
HPV vaccine administration and observed for 15 minutes
afterwards
6 | HPV vaccine attributes and storage conditions,
Module 2 CervarixTM | 24 July 2016
HPV vaccine storage conditions
 HPV vaccines should be stored
between +2oC and +8oC
 HPV vaccine is freeze sensitive
 HPV vaccine is light sensitive
7 | HPV vaccine attributes and storage conditions,
Module 2 CervarixTM | 24 July 2016
Temperature sensitivity of vaccines
Heat
sensitivity
Most
sensitive
OPV
MMR
Measles
Rotavirus
Rotavirus
Pentavalent
BCG
Vaccines to the
left of the line
are not damaged
by freezing
Least
sensitive
Pneumo
PS-PCV
HPV
Freeze sensitivity
8 | HPV vaccine attributes and storage conditions,
Module 2 CervarixTM | 24 July 2016
Freeze dried
Liquid, no adjuvant
Liquid, with alum
adjuvant
HepB
Least
sensitive
Vaccine formulation
Most
sensitive
Where to place HPV vaccine in the
refrigerator?
9 | HPV vaccine attributes and storage conditions,
Module 2 CervarixTM | 24 July 2016
Which vaccine vials should be stored in
front?
 Vaccine vials with early expiration dates and vials with VVM
that has started to change color should be kept in front
to be used first
Further expiry
date in back
Closer expiry
date in front
10 | HPV vaccine attributes and storage conditions,
Module 2 CervarixTM | 24 July 2016
Cold boxes and vaccine carriers
11 | HPV vaccine attributes and storage conditions,
Module 2 CervarixTM | 24 July 2016
Proper handling of 2-dose vial
of CervarixTM?
12 | HPV vaccine attributes and storage conditions,
Module 2 CervarixTM | 24 July 2016
Key messages
 CervarixTM vaccine is safe and effective
 CervarixTM is available as a single dose vial (0.5mL) and a 2-dose
vial (1.0mL) in a liquid, preservative-free formulation with VVM
 HPV vaccine is freeze sensitive and light sensitive
– HPV vaccines must be stored at +2oC to +8oC
– HPV vaccines should be stored in their original package
 When using icepacks in cold boxes and vaccine carriers, ensure
that icepacks are properly conditioned to reduce the risk of vaccine
freezing
 Discard any open vials with unused CervarixTM dose at the end of
the immunization session or 6 hours after opening, whichever
comes first
13 | HPV vaccine attributes and storage conditions,
Module 2 CervarixTM | 24 July 2016
End of module
Thank you
for your attention!
14 | HPV vaccine attributes and storage conditions,
Module 2 CervarixTM | 24 July 2016
References
 HPV vaccine introduction into national immunization
programmes: Information for programme managers and
health workers. WHO 2014
 CervarixTM package inserts. GlaxoSmithKline 2009
15 | HPV vaccine attributes and storage conditions,
Module 2 CervarixTM | 24 July 2016