Transcript ASU

ASU TVDC Progress Report
01/26/10
Kathryn F. Sykes and Stephen A. Johnston
Completed Milestones: 25, 26, 28 and 32, 33, 34
Active Milestones: ASU 35 & 36
Currently Inactive Milestones: 30, 37, 38
MILESTONE 35
Array hybridations with mouse RNAs
from virulent Schu 4 infection
& RT PCR confirmation of candidates
Gray: (sub )milestone title
Red: completed
Green: in progress
Virulent Schu 4 Samples
RT-PCR Confirmations
Initial samples
Dose-Response of Infection
Completed
Slide 2
MILESTONE 36
Final integration of expression data
and informatics analysis
Increasing
FTT0415
FTT0698
FTT1137c
Gray: (sub )milestone title
Red: completed
Green: in progress
Decreasing
Flat
FTT0560c FTT0103c
FTT1038c FTT0150
FTT1506
FTT1526
Slide 3
Increasing
FTT0415
FTT0698
FTT1137c
Decreasing
Flat
FTT0560c FTT0103c
FTT1038c FTT0150
FTT1506
FTT1526
Slide 4
Slide 5
Additional Points
• Description of deliverables completed for each active
milestone:
– MS 35: Microarray results with qPCR verification
– MS 36: Set of 9 proteins for testing as vaccine candidates
• List of relevant publications from the past month
•
ASU reports no TVDC publications in December 2009
• MSCR status
– MS28: Kathy-Completed and accepted by NIAID on 1/6/2010
– MS33: Mitch, ver 0.4 is pending at ASU; overdue to UNM approximately
12/18/09
– MS34: Mitch, ver 0.1 is pending at ASU; overdue to UNM approximately
12/17/09
– MS35: Mitch- completed work; ASU will write MSCR
– MS36: Mitch- completed work; ASU will write MSCR
Slide 8
Action Items
• Phillip: send revised analysis slides to Barbara. Slide 3 summary
gene set needs to match gene sets listed in later slides (done
1/26/10)
• Rick will want to review the ASU data and discuss with ASU on an
interim call before MS 35 and 36 are listed as completed and before
the ASU selected 9 gene candidates are considered for MS 37
• Barbara: will arrange an interim teleconference call between ASU
and UNM, regarding strategy and selection of vaccine candidates.
• MS33 MSCR: Mitch will email revised version to Barbara by 2/1/10
Monday.
• MS34 MSCR: Mitch will email a version to Barbara by 2/1/10
Monday.
• MS35 and MS36 MSCRs: ASU will start writing these now.
Slide 9