Transcript Tr_Nat_ImM_KM_Figs.ppt

Fig. 1
Pathogen invasion
DC
PRR
M
Neutrophil
Type 2
responses
Inflammation
Tissue
damage
IgA
IgG
Naïve
T cell
Type 1 /Proinflammatory
response
IL-1,
TNF-,
chemokines
Inflammation
IgE
B cell
IL-4,
IL-5, Th2
IL-6
Th1
Tissue damage
IFN-
(Autoimmunity)
CTL
(Allergic
reactions)
Eosinophil
recruitment
Cell
lysis
Tr cell
Fig. 2
Thymus
Naïve
CD8+CD25-
Naïve
CD4+CD25Antigen
(foreign or self)
CD4+CD25+
FoxP3+
Natural Tr cells
Th3
Tr1
Inducible Tr cells
CD8
Tr
Fig. 3
Natural Tr cells
Inducible Tr cells
CD4+CD25+
Fox3P+
Th3
Tr1
CD8
Tr
?
IL-10/TGF-
CTLA-4
APC
APC
APC
APC
Th1
Th2
CD8
 Proliferation
 IFN-
 Proliferation
 IL-4
MHCpeptide
Fox3P
CD25cell-to-cell
contact
 Proliferation
TCR
CD80/CD86
CD28
 CTL activity
 IFN-
 CD80/CD86
 APC function
 Inflammatory
cytokines
Fig. 4
Th1 cell promoting
pathogen molecules
(TLR ligands, e.g. LPS, CpG, viral RNA)
Tr1/Th3 cell promoting
pathogen molecules
(FHA, CyaA, CT, HCV-NS4, PS
+/- TLR ligands)
Th2 promoting
pathogen molecules
(helminth products, yeast hyphae,
CT, LT, TLR2 ligands)
TLRs
TLRs
MØ
CD11b/CD18, GM1
?
MØ
PRRs
Mature DC
CD80+, CD86+, CD40+
Mature
DC
CD86+,
OX40+
Semi-mature DC
CD80+CD40-
IL-12
IL-10, TGF-
IL-12, IL-27
IL-4, IL-6
Tr
Th1
IL-1, TNF-
IFN-
Type 1 responses
Pro-inflammatory
Immunity to intracellular pathogens
(Autoimmune diseases)
IL-10 / TGF-
Immune Regulation
Anti-inflammatory responses
Th2
IL-4, IL-5, IL-6 IL-10, IL-13
Type 2 responses
Immunity to extracellular pathogens
(Allergy)