Transcript Introductory PowerPoint

Genome generation
Timetable for today
Time
Activity
00:00
Introduction to the session
00:10
Story cards
00:20
Info cards
00:30
Issue cards
00:40
Discuss two key issues
00:45
Feedback your issues
What is DNA?
DNA’s code
A
C
G
T
What is a gene?
Coding
DNA
Non-coding
DNA
Protein
What is a genome?
Genetic variation
G A C T A G C T G A T C
G A C T A G
T C T G A T C
Sequencing technology
• Sequencing technology is
advancing rapidly.
• In 10 years DNA sequencing
will become part of routine
medical screening.
Image by Roy Kaltschmidt, LBNL.
What is genotyping?
• Genotyping involves looking at
particular regions of the
genome that are known to vary
between individuals.
• Information from genotyping
can indicate:
–
–
–
–
disease risk
drug responsiveness
carrier status for disease
personal traits such as eye colour.
Image by Kat M Research, Flickr.
What is genome sequencing?
• Genome sequencing
involves finding out
the whole sequence of
a person’s DNA.
• Commercially available
personal genome
sequencing currently
costs between £6,000
and £12,000.
Image courtesy of Wellcome Library, London
Genes vs environment
• A predisposition means
that people with a
particular genotype tend
to have an increased risk
of developing a disease.
• Lifestyle plays a
significant role in
increasing or decreasing
the risk of developing
some diseases.
Environment
Infectious
Disease
Obesity
Type 2
Diabetes
Genes
Monogenic
Story cards (10 minutes)
Info cards (10 minutes)
About the risk gene ApoE-e4
Genetic counselling
Issue cards (10 minutes)
Top issues (5 minutes)
• Decide what are the two top issues that come
out of the scenario.
• Highlight these as they will be used in
feedback session.
• Remember to write notes throughout the
discussion.
Discussion guidelines
• Speak for yourself and not for others.
• Allow others to finish before you speak. Listen well.
• Ask questions (???) as well as making statements (!!!)
• Explain what you think and feel.
• Respect differences in opinion. Find where you agree.
• Share your life experiences and knowledge – it is
valuable.
Genome generation