Transcript Presentation Slides

Improving the life-time of
dental composites
(Thiourethanes oligomers improve properties of
methacrylate-based dental restorative materials)
Carmem Pfeifer, DDS, PhD
[email protected]
Michelle Gunness, PhD, CLP
[email protected]
© 2015 Carmem Pfeifer/OHSU – ALL RIGHTS RESERVED
Slide 1
Executive Overview
 We, at the Biomaterials and Biomechanics Division at
OHSU, have developed a simple additive that will improve
the life-time of tooth-colored restorations. This additive
provides better resistance to fracture and more reliable
adhesion to tooth structure, without the need to change
the techniques dentists are currently using to restore
teeth, which makes the ROI (return on investment)
potentially very short.
Ultimately, improving current esthetic
materials will make them last as long as
amalgam restorations, without the
mercury exposure to patients.
© 2015 Carmem Pfeifer/OHSU – ALL RIGHTS RESERVED
Slide 2
Unmet Need
 Tooth-colored restorations made with dental composites
have become more common as they replace amalgam
metal fillings
 Unfortunately, composite restorations last only about 5-10
years, forcing their replacement. Not only is this costly for
the patient, but it also increases discomfort and makes the
original cavity larger.
Reasons for failure:
 Fracture
 Debonding (stress)
© 2015 Carmem Pfeifer/OHSU – ALL RIGHTS RESERVED
Slide 3
The Science
 Additives synthesized
through a simple method
in our lab have shown to
increase fracture
toughness and decrease
the stress at the interface
of such restorations
 Potential for improving
the life-time of dental
composites in the clinic
 Potential applications in
coatings industry (reduced
interfacial stress)
© 2015 Carmem Pfeifer/OHSU – ALL RIGHTS RESERVED
Slide 4a
The Science
 Toughness and crosslinking density define the probability of a material
resisting crack propagation and fracture when in service.
 The materials modified by these additives (only 6% of the total mass of
composite) present significantly higher toughness and crosslinking density,
as well as other improvements in mechanical properties.
© 2015 Carmem Pfeifer/OHSU – ALL RIGHTS RESERVED
Slide 4b
The Science
 Stress decreases of up to 60% are observed in spite of the
maintenance/increase in conversion.
 Clinically, this means that the interface tooth-restoration is not as
challenged as in current materials - increases in bond strength have also
been observed.
© 2015 Carmem Pfeifer/OHSU – ALL RIGHTS RESERVED
Slide 4c
The Science
• No need to change the current operatory technique –
potentially short return on investment
• For selected compositions, lower stress is achieved at
the same time mechanical properties increase –
unparalleled in the current market
• High molecular weight – ODORLESS
• High refractive index – optical clarity
• Thio-urethane bonds are more stable than ester bonds
in terms of hydrolitic degradation – more
biocompatible
• Platform for other applications?
© 2015 Carmem Pfeifer/OHSU – ALL RIGHTS RESERVED
Slide 4d
Project Management
TECHNOLOGY/IP
 Protected under PCT/US15/21016 (PIs: Pfeifer and Ferracane) for
dental application
PI
 Carmem Pfeifer, DDS, PhD – background in polymer chemistry and
dental materials (fully equipped lab for chemical synthesis and
mechanical testing)
Other faculty
 Jack Ferracane, PhD – background in mechanical testing and biofilm
formation/biocompatibility testing
Fully committed personnel to related projects in the lab
 2 post-doctoral associates (chemist/PhD; DDS/PhD)
 2 senior research assistants (chemist; biologist)
 2 research assistants (chemist; chemical engineer)
 7 graduate students (working towards PhD in Dental Materials)
© 2015 Carmem Pfeifer/OHSU – ALL RIGHTS RESERVED
Slide 5
Momentum
Need longer lasting restorations

These will benefit millions of patients whose restorations are replaced
every year, halting disease progression and preventing more costly
interventions.
Market Opportunity & Competition
 US market for dental materials:
over $1 billion as of 2013 (with
direct sales).
 Growth by 2020 to $1.5 billion.
 Dental composites are a
significant part of this market –
no product currently can achieve
high conversion/mechanical
properties and low interfacial
stress at the same time.
This can be achieved by this technology without
disruption to current dental technique/infrastructure – short ROI
© 2015 Carmem Pfeifer/OHSU – ALL RIGHTS RESERVED
Slide 6a
Momentum
 Can potentially be used in other polymer applications
where stress management is important
 UV Coatings
 3D printing
 Molded parts
 Ink/paints
 Others?
 At least two fundamental fields of use
© 2015 Carmem Pfeifer/OHSU – ALL RIGHTS RESERVED
Slide 6b
The Ask
Viability
NO NEED TO REINVENT THE WHEEL – SHORT ROI
 Create a company
 Too premature at this stage?
 Licensing partnership
 Currently having discussions
 Open to new business partners
 R&D partnership
 For clinical trials
 For non-dental related application
© 2015 Carmem Pfeifer/OHSU – ALL RIGHTS RESERVED
Slide 7
Contact information
 Carmem Pfeifer, DDS, PhD
OHSU School of Dentistry
2730 SW Moody Ave, Portland, OR, 97201
CLSB room 6N036
503-494-3288
[email protected]
© 2015 Carmem Pfeifer/OHSU – ALL RIGHTS RESERVED
Slide 7
Contact information
 Courtesy of Dr. Tom Hilton, Dr. Walter G. Miranda Jr and
Dr. Carlos Francci
 http://rhdentistry.com/dental-care-richmondhill/orthodontic-and-cosmetic/teeth-whitening/
 http://www.smilecenterclinics.com/cosmeticdentistry/teeth-whitening
 http://www.researchandmarkets.com/research/fk6vct/u
_s_market_for
© 2015 Carmem Pfeifer/OHSU – ALL RIGHTS RESERVED
Slide 7