Transcript 2005-2006 Officers

EOHSI is jointly sponsored by UMDNJ – Robert Wood Johnson Medical School and Rutgers, The State University of New Jersey.
Dermal Toxicology Specialty Section
What is Dermal Toxicology?
The Dermal Toxicology Specialty Section
The skin, as the largest and most visible organ of the body, is
subject to constant exposure to a wide range of materials.
These materials may be natural or synthetic and can be
biological, chemical or physical in origin. The skin itself may
be the target of these agents or they may be absorbed into the
body to cause toxicity in other organs. Dermal toxicology is,
therefore, the study of the adverse reactions of the skin
resulting from such exposures.
The Dermal Toxicology Specialty Section provides an
opportunity for interactions between scientists involved in
skin toxicology, pharmacology and basic skin biology. The
areas of research encompassed by Dermal Toxicology include
both mechanistic studies of toxicity to the skin itself as well
as toxicity to other organs due to absorption through the skin.
Of particular interest is the application of these results to the
production of risk assessment models for cutaneous exposure
to a wide range of potential toxicants, ranging from
environmental agents to synthetic chemicals to cosmetics. As
results, research within Dermal Toxicology has broad
applications in such areas as carcinogenesis, alternative
model systems, pharmacokinetics and regulatory issues.
A main focus of the research within the field of dermal
toxicology is involved in predicting such reactions when the
skin is exposed to a particular agent. Cutaneous risk
assessments are a primary tool used in the cosmetics industry
as well as determining both occupational and environmental
exposures.
In order to promote research within the field, the Dermal
Toxicology Specialty Section offers student and post-doctoral
awards at the SOT Annual Meeting for accepted abstracts as
recognition for exceptional research involving skin
toxicology and pharmacology. In the past, a generous
contribution from the publishing company, Taylor and
Francis, has supplemented these awards with a check and a
subscription to Cutaneous and Ocular Toxicology.
Dermal toxicology is also a major factor in the development of
topical pharmaceuticals. Transdermal delivery of medication
requires penetration of the skin barrier so as to maximize
absorption while minimizing local irritation and toxicity. The
formulation of medications targeted to the skin must also
achieve this balance. In addition, the application of materials
to the skin must be accounted for in pharmacokinetic models
for transport of substances throughout the body.
The Officers of the DTSS
Awards
Networking
Access to people in the field
President
Robert L. Bronaugh, Ph.D.
U.S. FDA
Interests: The percutaneous
absorption and metabolism
of topically applied chemicals
Vice-President
James N. McDougal, Ph.D.
Wright State University
Interests: skin absorption,
molecular biology of skin irritation,
systems biology, and biologically-based
toxicokinetic models
The Skin Quiz
Secretary-Treasurer
Cindy A. Ryan
Procter & Gamble
Interests: The development of a
cell-based in vitro alternative
method for skin sensitization
testing
Chemicals
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Ultraviolet light
Senior Councilor
Debra Laskin, Ph.D.
Rutgers University
Interests: Immunotoxicology, inflammation,
and immune mechanisms in liver and lung lnjury
Junior Councilor
Bill Reifenrath, Ph.D.
Stratacor Inc
Interests: Topical drug development,
models for skin absorption, chemistry of
arthropod attractants/repellents
Past-President
Nancy Monteiro-Riviere, Ph.D.
North Carolina State University
Interests: Dermatotoxicology, chemical absorption
and nanomaterial interactions with skin both in
vivo and in vitro
Student Representative
Adrienne Black
Rutgers University
Interests: Mechanisms of ultraviolet
light signal transduction
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Occupational Exposure
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Cosmetics and Lotions
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Why take the Skin Quiz?
1. It’s easy!
2. You’re guaranteed to pass!
3. You don’t have to study!
4. You’ll be registered to win a memory stick!
All participants will be entered into a drawing to win a
1 G memory stick. The winner will be announced at
the DTSS Annual Meeting on Wednesday, March 5 from
6:00 to 7:30 pm.
You have to be in it to win it!
Examples of dermatotoxic materials:
Poison Ivy
Free membership
Take the Skin Quiz
Vice-President Elect
David W. Hobson, Ph.D., DABT
H&H Scientific Services, LLP
Interests:Dermatopharmaceutical R&D,
tissue repair and wound healing product R&D,
risk assessment and toxicolkinetics /
pharmacokinetics
Basic research in skin biology also provides ample
opportunities for investigation in dermal toxicology. This
research offers a more complete understanding of the
molecular mechanisms underlying the processes involved in
the generation of these adverse reactions. With this
information, improved models could be produced that allow
for more accurate predications of potential toxicity as well as
provide potential molecular targets for the prevention and
treatment of these reactions.
Benefits of DTSS Membership
Jewelry
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