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Protein Kinase-Associated Receptors
• Receptor tyrosine kinases aggregate and undergo
autophosphorylation
– Add phosphate groups to particular amino acids
– Trigger a chain of signal transduction event- lead to cell growth,
proliferation or differentiation.
• Receptor tyrosine kinases initiated a signal transduction cascade
involving Ras and MAP kinase:
– GNRP (guanine-nucleotide release protein) = Sos + GRB2
• SH2 domain
– Ras: small monomeric G protein – the growth of cells.
– MAPK (MAP kinase): mitogen-activated protein kinases
– AP-1: Transcription Factor
• Receptor tyrosine kinases activate a variety of other signaling pathway
– PLC: phospholipase C (磷脂酶C)
• PLC-: activated by receptor tyrosine kinase
• PLC-: activated by G protein-linked receptors