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* Wnt proteins bind to frizzled receptors and
inhibit the degradation of b-catenin
Extracellular signal molecule
Receptor protein
Intracellular signaling proteins
Target proteins
Metabolic
enzyme
Gene regulatory
protein
Cytoskeletal
protein
Extracelluar signal
molecules bind to
specific receptors
Three classes of cell-surface receptors
or
or
Gene
transcription
is activated by
a rise in cAMP
conc
Amplifier and
transducer protein
Relay protein
Messenger protein
MAP-kinase serine/threonine
phosphorylation pathway activated by Ras
Raf
MEK
MAPK
Cytokine receptors activate the JakSTAT signaling pathway
JAKs
JAK1
JAK2
JAK3
Tyk2
Signal transducers
and activators of
transcription
* Wnt proteins bind to frizzled receptors and
inhibit the degradation of b-catenin