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指導教授：林鴻儒 教授 報 告 者：陳禹樵 民國九十八年九月四日 Introduction • Recent past has witnessed tremendous research work on naturally occurring polymers like sodium alginate and chitosan are gaining importance in the pharmaceutical field. Introduction • The dissolution studies has also been carried by novel approach called ‘flow through diffusion cell’ (FTDC), which maintains in vivo GI conditions to a greater extent as compared to the traditional dissolution test. Materials • • • • • • sodium alginate calcium chloride chitin riboflavin NaOH acetic acid Method vitamin B2 20 min 4% alginate 1% chitosan+1% acetic acid +4% CaCl2 S1 0.149 ± 0.003 cm 0.146 ± 0.008 cm 30 min 30 min 20 min S2 0.4% chitosan 1% alginate 1% CaCl2 Measurement • • • • Viscosity measurements Porosity measurement Determination of encapsulation efficiency Drug release study by FTDC and TDT method 72% 54% 5 cm 5 ml/ h (b) (a) (c) Conclusions • Calcium alginate/chitosan multilayered beads demonstrate a fair stability in the varying pH. • When studied by FTDC method the beads demonstrate slower release and are stable for nearly 11 h. Conclusions • The real significance of this study lies in the fact that these beads can be used to deliver antibiotics to treat gastric disorders and intestinal infections. Thank you for your attention!! chitin + 50 %NaOH 2hr 90度C chitosan dried at 50度C in vacuum washed three times with water and methanol ground and sieved into particle size range of 0.6–2 mm V2 V1 VT=V2-V3 Therefore porosity, X=[(V1-V3)/VT]*100 V3 The B2-loaded beads (50 mg) spectrophotometrically At room temperature for 24 h pulverized in 50 ml of 0.05 M phosphate buffer (pH 7.4)