Transcript PPT on Differentiation

X
Y
X
XX
XY
Genetic sex
X
Y
XO
XY
Genetic sex
no SRY
no TDF
SRY
Indifferent
gonad
Ovary
TDF
Testis
Gonadal sex
No Y sperm
Y sperm
XX
XY
SRY
TDF
No SRY
No TDF
testis
ovary
Mullerian
Ducts
Wolffian
Ducts
Mullerian
ducts
Oviduct,
uterus
degenerates
Wolffian
ducts
degenerates
Vas
deferens
Y sperm
No Y sperm
XX
XY
SRY
TDF
No SRY
No TDF
testis
ovary
Mullerian
Ducts
oviduct
Wolffian
Ducts
v. def
Testis
Mullerian
ducts
MIH
Oviduct,
uterus
Wolffian
ducts
T
Vas
deferens
Y sperm
No Y sperm
XX
XY
SRY
TDF
No SRY
No TDF
testis
No T ovary
No MIH
Mullerian
Ducts
T
MIH
T
oviduct
Wolffian
Ducts
v. def
Undifferentiated
genitals
Clitoris
Vagina
Penis
Scrotum
+ ovary
genitals
+ testis
genitals
Normally:
testis causes dev male genitals
ovary causes dev female genitals
+ ovary
genitals
genitals
+ testis
genitals
genitals
Testis
Undifferentiated
genitals
Clitoris
Vagina
Penis
Scrotum
X sperm
Y sperm
XX
XY
SRY
TDF
testis
ovary
Mullerian
Ducts
MIH
T
oviduct
Wolffian
Ducts
v. def
vagina
T
penis
Y sperm
No Y sperm
XX
XY
SRY
TDF
No SRY
No TDF
testis
No T ovary
No MIH
Mullerian
Ducts
MIH
T
oviduct
Wolffian
Ducts
v. def
vagina
T
penis
X sperm
Y sperm
XX
XY
SRY
TDF
testis
ovary
Mullerian
Ducts
T
MIH
T
oviduct
Wolffian
Ducts
v. def
vagina
penis
DHT
XY
testis
Mullerian
Ducts
Wolffian
Ducts
vagina
T
Y sperm
Androgen
Insensitivity
Syndrome
Testicular
Feminization
XY
SRY
TDF
testis
Mullerian
Ducts
T
MIH
T
Wolffian
Ducts
DHT
vagina