Stellingen

behorende bij het proefschrift:

Regulation of biliary cholesterol secretion and reverse cholesterol transport

Arne Dikkers 1. SR-BI contributes to ABCG5/8-independent biliary cholesterol secretion and RCT. (This thesis) 2. Although apoE overexpression increases SR-BI-mediated selective uptake it does not increase overall RCT. (This thesis) 3. MTP inhibition beneficially impacts RCT. (This thesis) 4. ABCG5/G8 mediate mass biliary cholesterol secretion from a pool that is not relevant for RCT. (This thesis) 5. The classic RCT pathway and TICE pathway might be connected by hepatic VLDL secretion. (This thesis) 6. The capacity to blunder slightly is the real marvel of DNA. Without this special attribute, we would still be anaerobic bacteria and there would be no music. (Lewis Thomas) 7. The past, like the future, is indefinite and exists only as a spectrum of possibilities. (Stephen Hawking)