Transcript Higher-order structure of chromosomes

Higher-order structure of chromosomes
Mateusz Skowron
Paweł Ślusarczyk
Supervisor: Joanna Deperas-Standyło
Theory
Human lymphocyte cell nucleus – filled with 23 pairs
of chromosomes containing DNA

Theory
Human lymphocyte cell nucleus – filled with 23 pairs
of chromosomes containing DNA

Chromosomes in phase G0/G1 have form
of long and screwed strings

Theory
Human lymphocyte cell nucleus – filled with 23 pairs
of chromosomes containing DNA

Chromosomes in phase G0 / G1 have form
of long and screwed strings

Firstly believed to form a chaotic
spaghetti-like structure

Theory
Human lymphocyte cell nucleus – filled with 23 pairs
of chromosomes containing DNA

Chromosomes in phase G0 / G1 have form
of long and screwed strings

Firstly believed to form a chaotic
spaghetti-like structure

1990’s – chromosomes prefer to rest
in some particuliar regions of the
nucleus, called domains or territories

Theory
Human lymphocyte cell nucleus – filled with 23 pairs
of chromosomes containing DNA

Chromosomes in phase G0 / G1 have form
of long and screwed strings

Firstly believed to form a chaotic
spaghetti-like structure

1990’s – chromosomes prefer to rest
in some particuliar regions of the
nucleus, called domains or territories

Theory
Human lymphocyte cell nucleus – filled with 23 pairs
of chromosomes containing DNA

Chromosomes in phase G0 / G1 have form
of long and screwed strings

Firstly believed to form a chaotic
spaghetti-like structure

1990’s – chromosomes prefer to rest
in some particuliar regions of the
nucleus, called domains or territories

Theory
Human lymphocyte cell nucleus – filled with 23 pairs
of chromosomes containing DNA

Chromosomes in phase G0 / G1 have form
of long and screwed strings

Firstly believed to form a chaotic
spaghetti-like structure

1990’s – chromosomes prefer to rest
in some particuliar regions of the
nucleus, called domains or territories

Nucleus model

Nucleus – sphere



Chromosomal domain –
sphere
Domains can overlap each
other
Chromosomal
domains in the
nucleus
CHROMOSOME MODEL
A real
chromosome

Model chromosome –
a chain of connected
spheres



Spheres in each
chromosome
cannot overlap
each other
Chromosomal territories in
the nucleus
Cпасибо for your attention!