Transcript KlingbeilMartin_2016_PHAP_Spring_Seminar_ppt.pptx

Sierra Leone Trial to Introduce a Vaccine against Ebola
(STRIVE) Site Operations Tracking and Evaluation:
PHAP Experiences with STRIVE
Martin J. Klingbeil, BS and Brittani Thomas, MPH
Public Health Associates, Class of 2014
Centers for Disease Control and Prevention
Office for State, Tribal, Local and Territorial Support
PHAP Spring Seminar
April 4, 2016
Centers for Disease Control and Prevention
Office for State, Tribal, Local and Territorial Support
September 2015 – January 2016
TWO 2014 PHAP EXPERIENCES IN
SIERRA LEONE
STRIVE Background

Sierra Leone Trial to Introduce a
Vaccine against Ebola
 Goal: To accelerate introduction and
use of an Ebola prevention vaccine
among at-risk people in Sierra Leone
with concurrent evaluation of the
efficacy and safety of the vaccine
 Study Design: Unblinded, phased,
individually randomized trial
 Eligibility: Health & frontline Ebola
workers ages 18+, not pregnant, HIV Sub-study participants in
reactogenicity and immunogenicity
 Study is ongoing and was worked on
by many CDC and COMAHS staff!
http://www.cdc.gov/vhf/ebola/strive/qa.html
Response Needs during our Deployments

Brittani: Sep 22 – Nov 18
 Vaccination Site Launch
• District support
• Mock vaccination dry-runs
 STRIVE Team Logistics
• Motor Fleet
• Accountability
 Site Operation Monitoring
• Tracking information on
appointment reminders
• Work with team leads on
target vaccination rates
• Tracked cumulative and
Site-specific vaccination

Martin: Nov 14 – Jan 10
 Site Operation Monitoring
• Work with team leads on
target vaccination rates
• Tracked cumulative and
Site-specific vaccination
• Unvaccinated participant
analysis
 CDC Sierra Leone
Management & Operations
• Supported stand-up of
permanent CDC SL Country
Office
• Staffing – LES & Deployer
Methods for Site Operation Monitoring

Data Collection Methods
 Document Review
• Cold Chain Reports, Vaccination schedules, site records etc.
 On site Observation/Interaction
• Current/Future Appointment Scheduling
• Root cause of no shows/ cancellations
o Troubleshooting with site staff
• Maintaining site records

Data Analysis:
 Reporting data reconciliation
• Unmet/met appointments
• Number vaccines drawn/ administered (Daily, weekly, cumulative)
 Microsoft Excel® Database
Accomplishments for PHAP Associates in Site
Operation Monitoring

Provide information to aid
in the improvement of
vaccine uptake
 Understanding of individual
sites and overall vaccination
patterns
 Improved site operation
monitoring reporting –
graphs & tables
• Cumulative and by-week
vaccination graphs

Help understand and
address barriers to
vaccination
 Train study staff to better
address participant barriers
 Improve study staff
reporting of participant
barriers
• Categorize, quantify and
graphically represent
commonly reported
barriers
 Understand barriers of
unvaccinated participants
Photos from the Field
Left, Brittani Thomas at cold storage facility. Center, Connaught Hospital entrance. Upper right, Martin Klingbeil
and Wilma Tanga (COMAHS) at Connaught Hospital. Lower right, vaccine dilution preparation at cold storage.
Special Thanks to the STRIVE Team, especially
Rosalind Carter Wertheim, Ph.D. – STRIVE Implementation Team
Victoria Carter, Ph.D. – STRIVE Communications Team
Martin J. Klingbeil, BS
Wilkes County Health Department – Wilkesboro, NC | [email protected]
Brittani Thomas, MPH
North Carolina State Health Department – Raleigh, NC | [email protected]
For more information, please contact CDC’s Office for State, Tribal, Local and Territorial Support
4770 Buford Highway NE, Mailstop E-70, Atlanta, GA 30341
Telephone: 1-800-CDC-INFO (232-4636)/TTY: 1-888-232-6348
E-mail: [email protected]
Web: http://www.cdc.gov/stltpublichealth
The findings and conclusions in this presentation are those of the authors and do not necessarily represent the official position of the
Centers for Disease Control and Prevention.
Centers for Disease Control and Prevention
Office for State, Tribal, Local and Territorial Support