Transcript Document 7724987

EFFECT OF EYE COLOR ON
SELECTIVE LASER
TRABECULOPLASTY
Elaine M. Miglino
Arusha Gupta, MD
Lawrence F. Jindra, MD
Financial Disclosures
1st and 2nd authors have no financial disclosure.
3rd author has independently conducted and financed
clinical research study presented and provides technical
advice and consultant services to Lumenis Corporation.
Introduction
Selective Laser Trabeculoplasty (SLT) uses a QSwitched frequency-doubled (532 nm) Nd:YAG laser
which targets melanocytes in the pigmented
trabecular meshwork.1,2 When treated with SLT, a
primarily biologic response is induced in the
trabecular meshwork which involves the release of
cytokines that trigger macrophage recruitment and
other changes leading to IOP reduction.2 It treats the
meshwork without causing any thermal or
coagulative damage to surrounding structures.1,2
1. Latina MA, et al. Selective targeting of trabecular meshwork cells: in vitro studies of pulsed and cw laser interactions. Exp Eye Res. 1995;60:359-372.
2. Latina MA, et al. Q-switched 532-nm Nd:YAG laser trabeculoplasty (selective laser trabeculoplasty): a multicenter, pilot, clinical study. Ophthalmology. 1998;105:2082-2090.
Objective and Methods
To examine the effect of eye color (blue or
brown) on SLT, in decreasing intraocular pressure
(IOP) in patients with glaucoma.
A retrospective chart review was performed on
137 eyes treated with SLT over 5 years; eyes were
grouped as blue or brown. Two-tailed paired t-test
and ANOVA were used to compare maximum preand post-SLT IOP.
Results: Blue Eyes
53 blue eyes were treated with SLT for
glaucoma; mean follow-up was 388 days.
IOP decreased from a mean of 18.5 to 13.6
mm Hg; this represents a 26% decrease in IOP.
Data were significant with P < 0.05.
Results: Brown Eyes
84 brown eyes were treated with SLT for
glaucoma; mean follow-up was 306 days.
IOP decreased from a mean of 19.5 to 13.3
mm Hg; this represents a 32% decrease in IOP.
Data were significant with P < 0.05.
Data
Blue Eyes
Brown Eyes
Number of eyes (n)
53
84
Mean follow-up (days)
388
306
Pre-SLT IOP (mm Hg)
18.5
19.5
Post-SLT IOP (mm Hg)
13.6
13.3
IOP change (mm Hg)
4.9
6.2
% ↓ IOP
26%
32%
P-value
< 0.05
< 0.05
Data
% Decrease in IOP
Eye Color vs Decrease in Post-SLT IOP
Blue Eyes
Brown Eyes
(n = 53 eyes)
(n = 84 eyes)
Summary
Mean Post-SLT Reduction in IOP:
Blue Eyes
26%
Brown Eyes
32%
The results were significant with P < 0.05.
Conclusion
In this series, SLT significantly lowered
mean IOP more in brown eyes and less in
blue eyes, suggesting a direct relationship
between eye pigment and post-SLT
reduction of IOP in patients with
glaucoma.