Transcript Scientific and educational achievements of the Neurology clinic, Clinical Center of Serbia

Scientific and educational
achievements of the Neurology clinic,
Clinical Center of Serbia
Academician Prof. dr Vladimir S. Kostic
Prof. dr Jelena Drulovic
Neurology Clinic
• Neurology clinic continues the best
tradition established by pioneer work
of Dr Laza Lazarević, father of the
modern Serbian neurology.
• The Clinic for Nerve and Mental
Diseases and at the same time
Department of Psychiatry and
Neurology were established on
October 10th, 1923.
Neurology Clinic
• Since its establishment all the way to
the present days, the institution has
always been a place of gathering of the
most eminent clinical neurologists from
Serbia, teaching base for the students,
and residents having neurological
advanced training in their curricula as
well as center for the scientific research
in the field of clinical and experimental
neurology.
Neurology Clinic
• Neurology clinic is technically
equipped for performing highly
specialized diagnostic procedures
(immunological and genetic
analyses, neurophysiological and
neuroradiological diagnostic
procedures).
Scientific contribution
• The Clinic of Neurology fosters intensive
scientific research activities intended at
better understanding of causes of the most
common brain diseases, establishment of
correct diagnosis and testing of the new
therapeutic possibilities.
• The results of basic and clinical research
are applied in everyday work with patients
aimed at developing of most up-to-date
diagnostic and therapeutic approaches.
Scientific contribution
• Dynamic development in the field
of neurosciences is particularly
apparent in the increasingly high
therapeutic potentials. Thus, our
Clinic carries out trials and tests of
efficacy and tolerability of the latest
therapeutic modalities in the field.
Neurology Clinic
• The Neurology Clinic, Clinical Center of
Serbia is a national leader, and among the
leading centers of neurology in the region
owing to its continuous professional and
technological development, in treating and
researching the most complex neurological
disorders, advancing innovations in
neurodegenerative disorders, epilepsy,
stroke, immune mediated nervous system
disorders.
• Annually, our staff of more than 40
specialists serves 10,000 patients with a
variety of neurological disorders.
Neurology Clinic – projects of the Ministry of Education
and Science of the Republic of Serbia (2011-2014)
175022: Nadežda Čovićković – Šternić: Depresija izazvana vaskularnim bolestima
mozga: primena neurovizualizacionih metoda u prevenciji, ranom otkrivanju i
lečenju.
175031: Jelena Drulović: Komparativna analiza kliničkih parametara i
biomarkera u prognozi evolucije multiple skleroze i drugih imunskih –
posredovanih neuroloških bolesti.
175083: Vidosava Rakočević – Stojanović: Ispitivanje molekularno-genetskih,
patohistoloških i biohemijskih karakteristika neuromišićnih bolesti.
175090: Vladimir Kostić: Motorni i nemotorni simptomi parkinsonizma:
kliničke, morfološke i molekularno-genetičke korelacije.
175087: Tatjana Pekmezović: Epidemiološka istraživanja neuroloških poremećaja:
sveobuhvatna procena efekata bolesti.
175091: Ivana Novaković: Analiza genetičkih markera mišićne distonije.
Università degli Studi di Ferrara
Enrico Granieri, Professor of Neurology
Head of the Department of Medical-Surgical Sciences of Communication&Behaviour
Chief of the U.O. Clinical Neurology, Ferrara
Director of the Schools of Specialization in Neurology and Neurosurgery
Chief of the MS Centre
Research project:
HLA-G and gelatinase interaction as potential biomarker of inflammatory network in Multiple
Sclerosis
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Massimo Filippi, Professor of Neurology
Director of the Neuroimaging Research Unit in the Department of Neurology
at the Scientific Institute and University Ospedale San Raffaele in Milan, Italy.
Multiple sclerosis
PhD theses
• Mesaroš Šarlota. Correlates of locomotor and
cognitive impairment in multiple sclerosis. A voxelbased morphometry study.
• Kačar Katarina. Correlation between Magnetic
Resonance Imaging (MRI) and neuropsychological
testing in patients with Multiple Sclerosis.
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Mesaros S, Rocca MA, Absinta M, Ghezzi A, Milani N, Moiola L, Veggiotti P, Comi G,
Filippi M. Evidence of thalamic gray matter loss in pediatric multiple sclerosis. Neurology
2008;70:1107-12.
Mesaros S, Rocca MA, Sormani MP, Charil A, Comi G, Filippi M. Clinical and conventional
MRI predictors of disability and brain atrophy accumulation in RRMS. A large scale, shortterm follow-up study. J Neurol 2008;255(9):1378-83.
Mesaros S, Rovaris M, Pagani E, Pulizzi A, Caputo D, Ghezzi A, Bertolotto A, Capra R,
Falautano M, Martinelli V, Comi G, Filippi M. A magnetic resonance imaging voxel-based
morphometry study of regional gray matter atrophy in patients with benign multiple sclerosis.
Arch Neurol 2008;65(9):1223-30.
Dujmović I, Mangano K, Pekmezović T, Quattrocchi C, Mesaroš Š, Stojsavljević N, Nicoletti
F, Drulović J.The analysis of IL-1 beta and its naturally occurring inhibitors in multiple
sclerosis: The elevation of IL-1 receptor antagonist and IL-1 receptor type II after steroid
therapy. J Neuroimmunol 2009;207:101-106.
Mesaros S, Rocca MA, Riccitelli G, Pagani E, Rovaris M, Caputo D, Ghezzi A, Capra R,
Bertolotto A, Comi G, Filippi M. Corpus callosum damage and cognitive dysfunction in
benign MS. Hum Brain Mapp 2009;30(8):2656-66.
Mesaros S, Rocca M, Sormani M, Valsasina P, Markowitz C, De Stefano N, Montalban X,
Barkhof F, Ranjeva J, Sailer M, Kappos L, Comi G, Filippi M. Bimonthly assessment of
magnetization transfer magnetic resonance imaging parameters in multiple sclerosis: a 14month, multicentre, follow-up study. Mult Scler 2010;16(3):325-31.
• Rocca MA, Mesaros S, Pagani E, Sormani MP, Comi G, Filippi M.
Thalamic damage and long-term progression of disability in multiple
sclerosis. Radiology 2010;257(2):463-9.
• Mesaros S, Rocca MA, Pagani E, Sormani MP, Petrolini M, Comi G,
Filippi M. Thalamic damage predicts the evolution of primary-progressive
multiple sclerosis at 5 years. AJNR Am J Neuroradiol 2011;32(6):1016-20.
• Rocca MA, Horsfield MA, Sala S, Copetti M, Valsasina P, Mesaros S,
Martinelli V, Caputo D, Stosic-Opincal T, Drulovic J, Comi G, Filippi M. A
multicenter assessment of cervical cord atrophy among MS clinical
phenotypes. Neurology. 2011;76(24):2096-102.
• Preziosa P, Rocca MA, Mesaros S, Pagani E, Stosic-Opincal T, Kacar K,
Absinta M, Caputo D, Drulovic J, Comi G, Filippi M. Intrinsic damage to
the major white matter tracts in patients with different clinical phenotypes
of multiple sclerosis: a voxelwise diffusion-tensor MR study. Radiology
2011;260(2):541-50.
• Kacar K, Rocca MA, Copetti M, Sala S, Mesaros S, Stosic Opincal T,
Caputo D, Absinta M, Drulovic J, Kostic VS, Comi G, Filippi M.
Overcoming the clinical-MR imaging paradox of multiple sclerosis: MR
imaging data assessed with a random forest approach. AJNR Am J
Neuroradiol 2011;32(11):2098-102.
• Mesaros S, Rocca MA, Kacar K, Kostic J, Copetti M, Stosic-Opincal T,
Preziosa P, Sala S, Riccitelli G, Horsfield MA, Drulovic J, Comi G, Filippi
M. Diffusion tensor MRI tractography and cognitive impairment in
multiple sclerosis. Neurology 2012;78(13):969-75.
• Comi G, Cohen JA, Arnold DL, Wynn D, Filippi M; FORTE Study Group.
Phase III dose-comparison study of glatiramer acetate for multiple
sclerosis. Ann Neurol. 2011;69(1):75-82.
• Comi G, Jeffery D, Kappos L, Montalban X, Boyko A, Rocca MA, Filippi
M; ALLEGRO Study Group. Placebo-controlled trial of oral laquinimod
for multiple sclerosis. N Engl J Med 2012;366(11):1000-9.
Neurodegenerative diseases
Kostić VS, Agosta F, Petrović I, Galantucci S, Spica V, Jecmenica-Lukic
M, Filippi M. Regional patterns of brain tissue loss associated with
depression in Parkinson disease. Neurology 2010;75(10):857-63.
Agosta F, Kostić VS, Galantucci S, Mesaros S, Svetel M, Pagani E,
Stefanova E, Filippi M. The in vivo distribution of brain tissue loss in
Richardson's syndrome and PSP-parkinsonism: a VBM-DARTEL study.
Eur J Neurosci 2010;32(4):640-7.
Kostić VS, Filippi M. Neuroanatomical correlates of depression and apathy
in Parkinson's disease: magnetic resonance imaging studies. J Neurol Sci
2011;310(1-2):61-3.
Longoni G, Agosta F, Kostić VS, Stojković T, Pagani E, Stošić-Opinćal T,
Filippi M. MRI measurements of brainstem structures in patients with
Richardson's syndrome, progressive supranuclear palsy-parkinsonism, and
Parkinson's disease. Mov Disord 2011;26(2):247-55.
Agosta F, Canu E, Stojković T, Pievani M, Tomić A, Sarro L, Dragašević
N, Copetti M, Comi G, Kostić VS, Filippi M. The topography of brain
damage at different stages of Parkinson's disease. Hum Brain Mapp
2012. doi: 10.1002/hbm.22101.
Agosta F, Pievani M, Svetel M, Ječmenica Lukić M, Copetti M, Tomić A,
Scarale A, Longoni G, Comi G, Kostić VS, Filippi M. Diffusion tensor MRI
contributes to differentiate Richardson's syndrome from PSPparkinsonism. Neurobiol Aging 2012.
Kostic VS, Agosta F, Pievani M, Stefanova E, Jecmenica-Lukic M,
Scarale A, Spica V, Filippi M. Pattern of brain tissue loss associated with
freezing of gait in Parkinson disease. Neurology 2012;78(6):409-16.
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