Transcript Document 7535816

Overview Of Geant4 Medical Activities At
Hampton UniversityJefferson Lab
Hampton University - Hampton, VA
http://www.jlab.org/~gueye/CAMI/cami_web
Jefferson Lab - Newport News, VA
http://www.jlab.org/glab
Source Uniformity
3D In-vivo Measurements
Energy Dependence
TeraWatt Lasers
Electromagnetic Physics
Other Research (p-therapy …)
Dr. Paul Gueye
Hampton University
G4NAMU - SLAC 2006
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Beta Detector
(Coll: NIST, Varian)
→ Uniformity/non-uniformity of sources
→ Absolute calibration of Brachytherapy sources
→ Removed transfer: films ↔ ionization chambers
→ Accuracy better than 100 μm (possibly: 50 μm)
PhD Thesis: Lawrence Tynes
Sr/Y-90
Preliminary
Deconvolve
Physics
Processes
Before
After
Data: 03/07/06
Dr. Paul Gueye
Hampton University
G4NAMU - SLAC 2006
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Air Bubbles: 20-80 m
GESiB
Medical Physics Parameters
(Coll: MGH, Laval, McGill, Varian)
 Dose Rate
 Anisotropic Function
 Radial Dose Function
z
Monte Carlo Codes
 General Particle Source (GPS)
 Gaussian/Fermi/… Distributions
y
Uniformity/non uniformity
 Density (water/air - 200 m layer)
Of Brachytherapy Sources
Results for 80 m
P-32: Φ=0.21 mm x L=20 mm
 5% effect on all parameters
Cylinders: number=100,wall =0.2 mm
 GPS/G (dE/dx): up to a factor of 2
AAPM: TG43/60, Dose rate @ surface & 2 mm
IAEA: %deviation from average (Req: <20%)
PhD Thesis: Nnenna Onumah
Dr. Paul Gueye
Hampton University
modifications in all parameters
 Patient density (dE/dx):
10% (up to ~0.5 mm) - preliminary
G4NAMU - SLAC 2006
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In-vivo Dose
Measurements
Z Dependence
XY Dependence
(Coll: DePaul Hospital, Varian)
→ Real Time Measurements
XYZ Dependence
→ Position, dose distribution
→ Treatment Plans:
Verification, Adjustments
PhD Thesis: Carlos Velasco
Data: 03/07/06
Dr. Paul Gueye
Hampton University
G4NAMU - SLAC 2006
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Active Mammosite
(Coll: Proxima Therapeutics, dePaul Hospital)
→ Real time measurements
→ Absolute position (≤ ±1 mm)
→ Absolute dose distribution
BSc (MSU): Jacquelyn Winston
Data: 03/07/06
HDR Source
BSc (HU): Thomas Cudjoe
Dr. Paul Gueye
Hampton University
G4NAMU - SLAC 2006
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Mono Energetic
Brachytherapy Sources
→ Energy dependence of cancer cells
(Coll: Jefferson Lab, EVMS, ODU)
PhD Thesis: Rachel Black (high energy)
Breast cancer cells
Master Thesis: Ariano Munden (qualitative)
PhD Thesis: Yuriy Prilepskiy (low energy)
Dipole
Collimator &
source (Sr-90)
0.3-1 MeV
1-2 MeV
New Data Sets: 03/07/06
AIP (2006 APS):
Newsletter/Nature/Science
Dr. Paul Gueye
Hampton University
G4NAMU - SLAC 2006
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Advanced Laser Light Source
Ultrafast & Interface Biology/Medecine
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Varennes, Canada
10 Hz, 300 mJ, 25 fs
Dynamic of biological processes
Radiation safety (monitoring program)
Charged beams characterization 100 Hz, 100 mJ, 25 fs
Medical Applications
Dr. Paul Gueye
Hampton University
G4NAMU - SLAC 2006
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Electromagnetic Physics In Geant4
 Experimental cross sections
 JLab, NIST: 20 eV to 60 MeV
 Unpolarized & Polarized Data
 JLab Mott polarimeter runs
Period: 1996-2006
Kinematics: 100 keV & 5 MeV – 173o
Targets: Au, Cu, Al
 New scattering chamber
Fall 2006, angular distribution
New detectors
208Pb(e,e’) - E = 100 MeV
~40% effect!
PhD Thesis: Michael Epps
 Theoretical understanding
 Coulomb corrections
 University of Basel & INFN
 Results by Summer 2006
Dr. Paul Gueye
Hampton University
G4NAMU - SLAC 2006
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Other Research
Proton therapy
New HU Center
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p
Construction: summer 2006
First beam: ~2009
Collaboration with MGH, Saclay & Orsay
Shielding calculation with Geant4
Postdoc: Vahagn Nazaryan
Polarized beams in cancer treatments
Jefferson Lab electron beam
DePaul Linac for electron and photon beams
PhD Thesis: Nanda Karthik
Kaon therapy
PhD Thesis: Solomon Sahle
Convolution product & Lyapunov stability
(Switzerland/France/Italy/Armenia)
– Nuclear Physics form factors (validation)
– Implementation in medical physics
K+
π+
Preliminary
Same depth = 28.5 cm
Medium = water
BS: Leslie Upton
Dr. Paul Gueye
Hampton University
G4NAMU - SLAC 2006
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! Questions !
Dr. Paul Gueye
Hampton University
G4NAMU - SLAC 2006
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