Transcript Is there a link between inflammatory bowel disease and the metabolic syndrome?

Is there a link between
inflammatory bowel disease and
the metabolic syndrome?
Hester Franks
Academic F2
Supervisors Professors Hawkey and Macdonald
Background and hypothesis
 Methods
 Results to date
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Background and hypothesis
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Inflammatory bowel disease (IBD)
 Crohn’s disease (CD)
 Ulcerative colitis (UC)
Metabolic syndrome
Genetic predisposition to both conditions
There seem to be an increasing number of obese
patients in IBD clinics.
Is it possible that in the obese patients it is their
obesity/the metabolic syndrome rather than these
polymorphisms which predisposes them to IBD?
Methods
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3 groups
CD BMI>28
 CD BMI<23
 Controls BMI>28
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2 parts to study
Genetic analysis for SNPs & baseline
metabolic analysis
 Detailed analysis of fasting and postprandial
metabolic state
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Results
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So far
167 UC patients
 110 CD patients
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Healthy volunteers being recruited by
advertisement
 No gene/metabolic data yet
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BMI distributions of UC and CD
BMI of Ulcerative Colitis patients
BMI of Crohn's Disease patients
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BMI
BMI
Conclusions to date
There does seem to be an overweight
subgroup in CD +/- UC
 SNP analysis may give us evidence that
some of the overweight patients have
IBD as a manifestation of the metabolic
syndrome
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