Document 7532742

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Transcript Document 7532742

Value-adding, Access, and Use:
Biological Databases as a Case
Study
Genes…..
…….make proteins
Proteins form complex 3D structures
Molecules
interact
the right molecules need to be
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EMBL nucleotide sequence database
Dataflow
EMBL
Flat
File
ID
XX
AC
XX
NI
XX
DT
DT
XX
DE
XX
KW
XX
OS
OC
OC
XX
RN
RP
RA
RT
RL
RL
RL
RL
XX
DR
XX
FH
FH
FT
FT
FT
FT
FT
FT
FT
FT
FT
FT
FT
FT
FT
XX
SQ
//
SLD746
standard; DNA; PRO; 477 BP.
D83746;
g1772347
18-JAN-1997 (Rel. 50, Created)
17-FEB-1997 (Rel. 50, Last updated, Version 2)
Streptomyces lividans DNA for ribosomal protein S12, complete cds.
ribosomal protein S12.
Streptomyces lividans
Eubacteria; Firmicutes; Actinomycetes; Streptomycetes;
Streptomycetaceae; Streptomyces.
[1]
1-477
Shima J.;
;
Submitted (06-MAR-1996) to the EMBL/GenBank/DDBJ databases.
Jun Shima, National Food Research Institute; Kannondai 2-1-2, Tsukuba,
Ibaraki 305, Japan (E-mail:[email protected], Tel:0298-38-8124,
Fax:0298-38-7996)
SPTREMBL; P97222; P97222.
Key
Location/Qualifiers
source
1. .477
/organism="Streptomyces lividans"
/strain="TK21"
28. .399
/db_xref="PID:g1772348"
/db_xref="SPTREMBL:P97222"
/product="ribosomal protein S12"
/translation="MPTIQQLVRKGRQDKVEKNKTPALEGSPQRRGVCTRVFTTTPKKP
NSALRKVARVRLTSGIEVTAYIPGEGHNLQEHSIVLVRGGRVKDLPGVRYKIIRGSLDT
QGVKNRKQARSRYGAKKEK"
289
/replace="g"
/phenotype="streptomycin resistant mutant TK24"
CDS
mutation
Sequence 477 BP; 99 A; 153 C; 152 G; 73 T; 0 other;
ATTCGGCACA CAGAAACCGG AGAAGTAGTG CCTACGATCC AGCAGCTGGT
CGGCAGGACA AGGTCGAGAA GAACAAGACG CCCGCACTCG AGGGTTCGCC
GGCGTCTGCA CGCGTGTGTT CACGACCACC CCGAAGAAGC CGAACTCGGC
GTCGCGCGTG TGCGTCTGAC CAGTGGGATC GAGGTCACCG CTTACATTCC
CACAACCTGC AGGAGCACTC CATCGTGCTC GTGCGCGGCG GCCGTGTGAA
GGTGTTCGCT ACAAGATCAT CCGCGGTTCG CTTGACACCC AGGGTGTGAA
CAGGCCCGCA GCCGCTACGG CGCCAAGAAG GAGAAGTAAG AATGCCTCGT
CCCCGAAGCG CCCGGTCATC ATCGACCCGG TCTACGGTTC TCCTCTGGTG
CCGGAAGGGC
CCAGCGCCGT
CCTGCGTAAG
GGGTGAGGGG
GGACCTGCCG
GAACCGCAAG
AAGGGCCCCG
ACCTCCC
60
120
180
240
300
360
420
477
EMBL Relational Schema
PATENTABSTRACT @ PRDB1PATENTAPPLICANT
(#)
PATENTCLASS @ PRDB1 PATENTPRIORITY @ PRDB1
@ PRDB1
* ABSTRACT
# * PUBID
* USERSTAMP
* TIMESTAMP
FK_PATENTABSTRACT_1
COMMENT_TEXT @ PRDB1 (#)
KEYWORD @ PRDB1 (#)
KEYWORD_SYNONYM @ PRDB1 (#)
# * COMMENTID
# * LIN E#
* TOPICTYPE
o PRIVATE
o TEXT
...
* COMPRESSED_KW
* KEYWOR D
# * KEYWORDID
o DBC OD E
o DESCRIPTION
* USERSTAMP
* TIMESTAMP
# * KEYWORDID 1
# * KEYWORDID 2
* APPNAME
* ORD ERIN
* PUBID
* USERSTAMP
* TIMESTAMP
* CLASS
* CLASS_ ORD ER
* PUBID
* USERSTAMP
* TIMESTAMP
FK_PATENTCLASS_98
FK_PATENTAPPLICANT_2
* PRIORITY_D ATE
* PRIORITY_N O
* PRIORITY_OFFIC E
* PRIORITY_ORDER
* PUBID
* USERSTAMP
* TIMESTAMP
INSTITUTE @ PRDB1 (#)
# * INSTITU TE#
* INSTITU TE_N AME
* USERSTAMP
* TIMESTAMP
FK_PATENTPRIORITY_97
PATENT @ PRDB1 (#)
PERSONALCOMM @ PRDB1
* DOC NUM
* DOC OFFICE
* DOC TYPE
# * PUBID
o APPDATE
o APPNUM
o APPOFFICE
* USERSTAMP
* TIMESTAMP
* ADD RESS
* PUBID
* REC IPIENT
o PHONEID
* USERSTAMP
* TIMESTAMP
SUBMISSIONREF @ PRDB1 (#)
ACCEPTED @ PRDB1 (#)
JOURNALARTICLE @ PRDB1 (#)
BOOK @ PRDB1 (#)
THESIS @
PRDB1 (#)
FK_THESIS_106
# * PUBID
o DS#
o MED IUM
* USERSTAMP
* TIMESTAMP
* ISSN
# * PUBID
o ARTICLETYPE
o FIRSTPAGE
o ISSU E
o LASTPAGE
o ORD ER _ON _PAGE
o SUPPLEMEN T
o VOL UME
* USERSTAMP
* TIMESTAMP
* FIRSTPAGE
* ISSN
# * PUBID
* VOL UME
o ARTICLETYPE
o ISSU E
o LASTPAGE
o ORD ER _ON _PAGE
o SUPPLEMEN T
* USERSTAMP
* TIMESTAMP
* BOOKTITLE
* FIRSTPAGE
* LASTPAGE
# * PUBID
* PUBLISH ER
o EDITION
o ISBN
o PUBPLACE
o SER IES
o VOL UME
* USERSTAMP
* TIMESTAMP
* INSTITU TE#
# * PUBID
o ADVISOR
o DEGREE
* USERSTAMP
* TIMESTAMP
FK_DBENTRY_KEYWORD_40
FK_PATENT_77
DBENTRY_COMMENT @ PRDB1 (#)
DBENTRY_KEYWORD @ PRDB1
# * COMMENTID
# * DBENTR YID
* USERSTAMP
* TIMESTAMP
FK_PERSONALCOMM_3
FK_SUBMISSIONREF_119
FK_THESIS_84
FK_UNPUBLISHED_114 FK_JOURNALARTICLE_66
* KEYWOR DID
* DBENTR YID
o USERSTAMP
o TIMESTAMP
FK_BOOK_59
FK_DBENTRY_COMMENT_100
FK_DBENTRY_KEYWORD_39
DBENTRY @ PRDB1 (#)
* BIOSEQID
# * DBENTR YID
* ENTRY_ NAME
* ENTRY_ STATUS
* PRIMARYACC #
* VER SION #
o ANN _DATE
o CLEAN_ LISTING
o CON FID ENTIAL
o DBC OD E
o EXT_DATE
o EXT_VER
o FIRST_C REATED
o FIRST_PUBL IC
o HOL D_D ATE
o MISSING_PAPER
o PROJEC T#
o SUBMIT_TOOL
o WAIT_FOR_PAPER
* USERSTAMP
* TIMESTAMP
o FFD ATE
PUBLICATION @ PRDB1 (#)
FK_THESIS_85
# * PUBID
* PUBLAN G
* PUBSTATUS
* PUBTYPE
o PUBDATE
o TITL E
* USERSTAMP
* TIMESTAMP
FK_PATENT_BIOSEQ_108
FK_PUB_XREF_1
FK_PUBAUTHOR_83
PUB_XREF @ PRDB1
* PUBID
* DBC ODE
* PRIMARYID
FK_CITATIONBIOSEQ_60
FK_DBENTRY_DESCR_117
FK_DBENTRY_25
PUBAUTHOR @ PRDB1
* ORD ERIN
* PER SON
* PUBID FK_PUBAUTHOR_82
o EDITOR FLAG
* USERSTAMP
* TIMESTAMP
PERSON @ PRDB1 (#)
# * PER SONID
* SUR NAME
o FIRSTNAME
o MID INITIALS
* USERSTAMP
* TIMESTAMP
FK_ACC
FK_ACCPAIR_127
ACCPAIR @ PRDB1 (#)
DBENTRY_DESCR @ PRDB1 (#)DATABASE_XREF @ PRDB1
# * PRIMAR Y
# * SEC ON DAR Y
* USERSTAMP
* TIMESTAMP
# * DBENTR YID
# * LIN E#
* TEXT
o USERSTAMP
o TIMESTAMP
* EBI_ DB
* ACC #
o NID _TEXT
o PID _TEXT
* EXT_DB
* PRIMARYID
o SEC OND AR YID
Sequence Info
PATENT_BIOSEQ @ PRDB1 (#)
CITATIONBIOSEQ @ PRDB1 (#)
* ORD ERIN
# * PUBID
# * SEQID
* USERSTAMP
* TIMESTAMP
* ORD ERIN
# * PUBID
# * SEQID
o CITC OMMEN T
o FUL LSEQ
o LOC NOD EID
o LOC TYPE
* USERSTAMP
* TIMESTAMP
FK_PATENT_BIOSEQ_107
FK_CITATIONBIOSEQ_61
PHYSICALSEQ @ PRDB1 (#)
BIOSEQ @ PRDB1 (#)
* BIOSEQTYPE
* CHKSUM
* MOL ECU LETYPE
# * SEQID
* SEQLEN
o DDBJSID
o EBISID
o LOGSEQ
o NCBIGI
o PHYSEQ
* USERSTAMP
* TIMESTAMP
FK_BIOSEQ_5
FK_NUCSEQ_76
# * PHYSEQID
* SEQTEXT
* USERSTAMP
* TIMESTAMP
Reference Info
FK_PROTEINSEQ_81
NUCSEQ @ PRDB1 (#)
PROTEINSEQ @ PRDB1 (#)
* A_C OUN T
* C_C OUN T
* G_C OUN T
* OTH ER_ COU NT
# * SEQID
* T_C OUN T
o STR AND
o TOPOLOGY
* USERSTAMP
* TIMESTAMP
# * SEQID
o DER IVED
o MOL WEIGHT
* USERSTAMP
* TIMESTAMP
FK_LOCATION_TREE_68
FK_BIOSEQ_4
FK_LOCATION_TREE_72
LOCATION_TREE @ PRDB1 (#)
FK_PROTEINCODINGFEATURE_13
FK_SEQFEATURE_36
FK_TRANSLATIONEXCEPTION_110
FK_CITATIONSEQFEATURE_92
# * LOC NODEID
* ORD ER_ IN
o COMPLEMEN T
o END _FSIZE
o END _FTYPE
o GAP_FSIZE
o GAP_FTYPE
o LITERAL
o OPERATOR
o PAR ENTID
o REPLAC E
o REPL_STRIN G
o SEG_EN D
o SEG_GAP
o SEG_START
* SEQID
o START_ FSIZE
o START_ FTYPE
* USERSTAMP
* TIMESTAMP
FK_PROTEINSEQ_80
PROTEINCODINGFEATURE @ PRDB1 (#)
GENE @ PRDB1 (#)
# * FEATID
* FKEY#
* PROTEIN SEQID
o ENU MBER
o PSEUDO
o READIN GFR AME
o TRANSL _TABLE_ ID
* USERSTAMP
* TIMESTAMP
FK_PROTEINCODINGFEATURE_12
# * GEN EID
* GEN ENAME
o DBC OD E
o EXTDBID
o ORGANISM
o PATHOL OGY
o PRODU CT
* USERSTAMP
* TIMESTAMP
SOURCEFEATURE @ PRDB1 (#)
FK_GENE_64
NTX_RANK @ PRDB1 (#)
o RAN K_ID
# * RAN K_TXT
FK_RANK
NTX_SYNONYM @ PRDB1
FK_NTX_SYNONYM_46
* TAX_ ID
* NAME_TXT
o UNIQUE_NAME
o NAME_C LASS
* UPPER_ NAME_TXT
NTX_TAX_NODE @ PRDB1 (#)
# * TAX_ID
o PAR ENT_ID
o RAN K
o EMBL_C ODE
o DIV_ ID
* INHERIT_DIV_ID
o GC_ ID
o INH ERIT_GC _ID
o MGC _ID
o INH ERIT_MGC_ID
* HIDD EN
o NO_ SEQUEN CE
o REMARK
FK_SOURCEFEATURE_21
# * FEATID
* FKEY#
o ORGANISM
o CHR OMOSOME
o FREQUENC Y
o HAPLOTYPE
o NUC SOURC E
o ORGANELLE
o SEQUEN CED
o SEX
o VIRION
* USERSTAMP
* TIMESTAMP
FK_CODONEXCEPTION_50
FK_NAME_CLASS
FK_TRANSLATIONEXCEPTION_51
o CLASS_ COD E
# * CLASS_ TEXT
o PRIORITY
* AMIN OAC ID
* FEATID
* TRANSXEND
# * TRANSXID
* TRANSXSTAR T
o BIOSEQID
* USERSTAMP
* TIMESTAMP
CITATIONSEQFEATURE @ PRDB1 (#)
FK_SOURCEFEATURE_20
# * FEATID
* FKEY#
o ENU MBER
o FREQUENC Y
o MOD BASE
o ORGANISM
o RPTFAMILY
* USERSTAMP
* TIMESTAMP
FK_CITATIONSEQFEATURE_10
RNAFEATURE @ PRDB1 (#)
* FEATID
* LINE#
* NOTE#
* TEXT
o USERSTAMP
o TIMESTAMP
FEATURE_RELATIONSHIP @ PRDB1 (#)
FK_FEATURE_RELATIONSHIP_28
# * FEATID
* FKEY#
o ANTICODON AA
o ANTICODON END
o ANTICODON START
o PSEUDO
* USERSTAMP
* TIMESTAMP
# * FEATID
# * PUBID
# * SEQID
* USERSTAMP
* TIMESTAMP
SEQFEATURE_NOTE @ PRDB1
FK_SEQFEATURE_NOTE_78
FK_NUCSTRUCTUREFEATURE_55
NTX_CLASS @ PRDB1 (#)
* AMIN OAC ID
* COD ONSEQ
# * CODON XID
* FEATID
o USERSTAMP
o TIMESTAMP
TRANSLATIONEXCEPTION @ PRDB1 (#)
NUCSTRUCTUREFEATURE @ PRDB1 (#)
FK_NUCSTRUCTUREFEATURE_57
Location Info
CODONEXCEPTION @ PRDB1 (#)
SEQFEATURE @ PRDB1 (#)
* BIOSEQID
# * FEATID
* FTYPE#
* LOC ATION
* ORD ER_ IN
o EVID EN CE
o FEAT_LABEL
o INC OMPLETE
o SUBMITTOR
* USERSTAMP
* TIMESTAMP
FK_FEATURE_RELATIONSHIP_29
# * FEATID1
# * FEATID2
# * REL ATION
* USERSTAMP
* TIMESTAMP
FK_SEQFEATURE_35
RPTUNIT @ PRDB1
FK_RNAFEATURE_15
FK_RPTUNIT_109
* FEATID
o RPTID
o LABEL
o RPTEND
o RPTSTART
* USERSTAMP
* TIMESTAMP
TRANSCRIPTFEATURE @ PRDB1 (#)
# * FEATID
* FKEY#
o ENU MBER
o FIVE_CONS
o PSEUDO
FK_TRANSCRIPTFEATURE_52
o READIN GFR AME
o THR EE_ CON S
* USERSTAMP
* TIMESTAMP
FEATURE_QUALIFIERS @ PRDB1 (#)
FK_FEATURE_QUALIFIERS_121
FK_ERROR_QUALIFIERS_122
Taxonomy Info
SIGNALFEATURE @ FK_SIGNALFEATURE_18
PRDB1 (#)
# * FEATID
# * OR DER _ON
* QUAL#
o TEXT
o USERSTAMP
o TIMESTAMP
ERROR_QUALIFIERS @ PRDB1 (#)
# * FEATID
# * OR DER _ON
# * FEATID
* FKEY#
o DIR ECTION
o PSEUDO
* USERSTAMP
* TIMESTAMP
IMMUNOFEATURE @FK_IMMUNOFEATURE_7
PRDB1 (#)
# * FEATID
* FKEY#
o CHIMER IC
o PSEUDO
o READIN GFR AME
o TRANSL _TABLE_ ID
* USERSTAMP
* TIMESTAMP
VARIATIONFEATURE
@ PRDB1 (#)
FK_VARIATIONFEATURE_48
# * FEATID
* FKEY#
o FREQUENC Y
o REPLAC E
* USERSTAMP
* TIMESTAMP
UNCLASSIFIEDFEATURE
@ PRDB1 (#)
FK_UNCLASSIFIEDFEATURE_118
# * FEATID
* FKEY#
o USERSTAMP
o TIMESTAMP
Feature Info
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•Research staff: Kristian Axelsen, Pierre-Alain Binz, Nicolas Hulo, Anne-Lise Veuthey
•Clerical/secretarial assistance: Veronique Mangold, Claudia Sapsezian, Margaret Shore-Nye,
Veronique Verbegue
•Students: Pavel Dobrokhotov, Alexandre Gattiker, various MCF, etc