Transcript Protein Crystals In Space In Florida Schools

Protein Crystals In Space
In Florida Schools
Protein Crystals in
Space in Florida
Schools
K-16 Outreach Grant Program
Sponsored by
The Florida Space Grant
Consortium
Principal Investigator
Dr. Marianne Barnes
The Univ. of North Florida
http://florida-protein-crystals-in-space.org
Program Manager and Instructor
Robert S. Smith
Terry Parker High School
Jacksonville, Florida
Protein Crystals in
Space in Florida
Schools
National Sponsors
• Dr. Alex McPherson (Chief Scientist)
• Greg Jenkins
(Chief of Engineering TeamMarshall Space Flight Center)
Protein Crystals in
Space in Florida
Schools
What is Structural Biology?
1. DNA and Recombinant Technology
2. Protein Purification and Analysis
3. Protein Crystallization
4. X-Ray Crystallography
5. 3-Dimentional Protein Models
6. Rational Drug Design
Protein Crystals in
Space in Florida
Schools
Step 1
DNA and how it is used in
Recombinant Technology
This research is conducted by
universities and NASA facilities
Protein Crystals in
Space in Florida
Schools
Step 2
Protein Purification and Analysis
This research is also conducted by
universities and NASA facilities
Protein Crystals in
Space in Florida
Schools
Step 3
• Protein Crystallization and
Crystallography
This is where we get involved!
Students prepare the
flight payload samples
• Why is Microgravity Important?
Protein Crystals in
Space in Florida
Schools
Why is Space (microgravity)Important?
Protein Crystals in
Space in Florida
Schools
The Search For The Perfect Crystal
Protein Crystals in
Space in Florida
Schools
Step 4
X-Ray Crystallography
When samples return from
space, they are studied at
The University of California at Irvine
to determine the atomic structure
of the protein.
Protein Crystals in
Space in Florida
Schools
Step 5
Computer Graphics and
3-D Protein Models
When the atomic structure is known,
researchers can identify sites of active
enzyme production for the protein!
Protein Crystals in
Space in Florida
Schools
Step 6
Rational (Structured)
Drug Design
Medical researchers can then
design drugs that block the
enzyme production at the
active sites
Protein Crystals in
Space in Florida
Schools
How can you get your students
involved in this program?
Protein Crystals in
Space in Florida
Schools

Teacher Workshops

Students conduct lab activity

Students do research projects/essays

Advanced Student Workshop

Space Shuttle Launch
Protein Crystals in
Space in Florida
Schools
Teacher Workshops
Protein Crystals in
Space in Florida
Schools
Students conduct lab activity

Students do research projects/essays

Protein Crystals in
Space in Florida
Schools
Advanced Student
Workshop
Dave Hall and Merle Myers
Protein Crystals in
Space in Florida
Schools
Making Flight
Samples
John Perkey
Protein Crystals in
Space in Florida
Schools
Inspecting the
flight sample
Wendell Elrod
Protein Crystals in
Space in Florida
Schools
Anna Holmes’
Crystallization Module
Protein Crystals in
Space in Florida
Schools
Anna Holmes’
Crystallization Module
Protein Crystals in
Space in Florida
Schools
Space Shuttle
Launch Activity
3 launches so far
over 100 payload samples
by Florida students/teachers
Protein Crystals in
Space in Florida
Schools
STS-106
9/08/2000
Atlantis
STS-98
2/7/2001
Atlantis
STS-110
4/8/2002
Atlantis
Protein Crystals in
Space in Florida
Schools
Advanced Students
Research
Mentoring
Presentations
Internships
Protein Crystals in
Space in Florida
Schools
Advanced
Student
Research
Protein Crystals in
Space in Florida
Schools
Mentoring
Protein Crystals in
Space in Florida
Schools
Presentations
Greg Jenkins
Protein Crystals in
Space in Florida
Schools
Internships
Protein Crystals in
Space in Florida
Schools