Transcript Dr Jibrin Paul Consutant Anatomic Pathology NH

Dr Jibrin Paul
Consutant Anatomic Pathology NH
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A group of mycotoxin poison formed by
mould aspergillus flavus
They grow in damp and warm environment in
peanut, cereal and rice, wheat almonds
walnut, corn and sunflower seed
Contamination occur during the process of
storage processing and transportation
Animals fed with infected cereal and grain
can also transmit the virus through their milk
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Several different toxin are known that cause
acute toxicity
Aflatoxin B1 is Carcinogen
The fact has been known for more than four
decade ago
NIEHS funder John Hopkins university
research discovered the role of Aflatoxin in
promoting liver cancer
It cause mutation in critical cancer genes P53
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It cause mutation in p53 by forming DNA
adduct
Measurement of this DNA adduct can be
carried out in Urine and blood
It’s a sensitive Biomarker to determine level
of exposure in a community
Interaction between Aflatoxin and Hepatitis B
virus in promoting liver cancer has been well
documented , increase risk by 60 times
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Is a hepatotrophic virus known to cause
Acute fulminant hepatitis and death
Chronic hepatitis and liver cirrhosis
Hepatocellular carcinoma
Transmitted by sexual intercourse
Blood transfusion
Feto-maternal transfer, mother to child
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Highest incidence is seen in tropical subSaharan Africa Nigeria inclusive
Major cause of liver cancer in young Adult
Evil marriage between HBV and Aflatoxin Bi
increase the risk of liver cancer 60 times
more than unexposed individual
Sub-Saharan Africa also happen to be the
area of highest exposure rate of aflatoxin
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Proper storage and transportation of our
grains and cereal
Measurememt of the Biomakers of the DNvA
adduct in our population
Use of Chlorophylin extract of the chlorophyl
in green vegetatble to reduce the effect of the
toxin
Vaccnation for HBV in our population
Finally safe sex for marriage will do alot