Transcript Corporate EHS Strategic Perspective

Corporate EHS Strategic
Perspective
Michael Rottas
Associate Director, Environmental Health & Safety
Pfizer Global R&D – Groton/New London Laboratories
• Pfizer is the largest pharmaceutical company
in the world.
– Human health
– Consumer health care
– Animal health
• ~120,000 employees worldwide
• Operations in 150 countries
• Largest privately funded research
organization in the world.
– Now ~$8 billion/year
– Groton Labs ~$1.5 billion/year
• Global Environmental Management Initiative
(GEMI) member
• UN Global Compact member
• EPA Climate Leaders participant
• Public Environmental Goals:
– Reduce CO2 emissions by 35% by 2007 (2000 as
baseline)
– 35% of global electricity needs by 2010 from clean
sources
– Phase out of Class I ODCs by 12/31/2005
Where we were…
• EHS professionals, in Corporate setting, were
necessary overhead due to compliance
requirements
• Outsiders from manufacturing and operating
units
• Us vs. them
• Niche role
• Reactive
• After the fact
• End-of-line control
Where we are…
• EHS professionals are a respected
participant in the business process
• We are at the table
• Resource for business risk minimization and
continuity planning (post Y2K, post
9/11/2001)
• Skills transferable, financially savvy
• Proactive and preventative
• Third party EMS registrations
Where we are going…
• Holistic approach to sustainable practices
• Integrated EHS management systems
• No longer separate, but integrated into core
business functions
• Technical professionals with sophisticated
business skills (MBAs routine)
• Everyone is involved, cultural approach
Industrial Evolution
• Sustainability becoming more commonplace
within the core business of leading
businesses
– Hybrid cars becoming mainstream
– Petrochemical companies working on alternative
fuels
– Carpet companies making recyclable carpets
– Pharmaceutical companies doing green chemistry
• Investment firms recognize value in
sustainable practices
What is green chemistry?
“…the utilization of a set
of principles that reduces
or eliminates the use or
generation of hazardous
substances in the design,
manufacture and
application of chemical
products.”
*Source: Paul T. Anastas and John C. Warner, Green Chemistry: Theory
and Practice (New York, NY: Oxford University Press Inc., 1998).
ISBN 0 19 850698 8
12 Principles of Green Chemistry*
1. It is better to prevent waste than to treat or clean up waste after it
has formed.
2. Synthetic methods should be designed to maximize the
incorporation of all materials used in the process into the final
product.
3. Wherever practicable, synthetic methodologies should be
designed to use and generate substances that possess little or
no toxicity to human health and the environment.
4. Chemical products should be designed to preserve efficacy of
function while reducing toxicity.
5. The use of auxiliary substances (e.g. solvents, separation
agents, etc.) should be made unnecessary wherever possible
and innocuous when used.
6. Energy requirements should be recognized for their
environmental and economic impacts and should be minimized.
Synthetic methods should be conducted at ambient temperature
and pressure.
12 Principles of Green Chemistry*
7.
A raw material or feedstock should be renewable rather than
depleting wherever technically and economically practicable.
8. Unnecessary derivatization (blocking group,
protection/deprotection, temporary modification of
physical/chemical processes) should be avoided wherever
possible.
9. Catalytic reagents (as selective as possible) are superior to
stoichiometric reagents.
10. Chemical products should be designed so that at the end of their
function they do not persist in the environment and break down
into innocuous degradation products.
11. Analytical methodologies need to be further developed to allow for
real-time, in-process monitoring and control prior to the formation
of hazardous substances.
12. Substances and the form of a substance used in a chemical
process should be chosen so as to minimize the potential for
chemical accidents, including releases, explosions and fires.
Raw Materials
Energy
Natural Resources
NDA
Intellectual
Property
Raw Materials
Energy
Natural
Resources
Global R&D
Clinical Supply
Air Emissions
Solid/Hazardous
Wastes
Wastewater
Product
PGM
Waste
Raw Materials
Energy
Natural Resources
NDA
Intellectual
Property
Raw Materials
Energy
Global R&D
Natural
Resources
PGM
Waste
Clinical Supply
Air Emissions
Solid/Hazardous
Wastes
Wastewater
Waste Minimization
Pollution Prevention
Product
Control at the source,
treat on or off-site,
recycle where possible.
Reduce, reuse, recycle.
Raw Materials
Energy
Green Chemistry
Natural Resources
NDA
Intellectual
Property
Raw Materials
Energy
Global R&D
Natural
Resources
Clinical Supply
Air Emissions
Solid/Hazardous
Wastes
Wastewater
Waste Minimization
Pollution Prevention
Product
PGM
Waste
Sertraline (Zoloft)
• Solvent use reduced from 60,000 to 6,000 gallons
per ton of sertraline
• Eliminated the use of 440 metric tons of titanium
dioxide per year
• Eliminating the use 150 metric tons of 35%
hydrochloric acid per year
• Eliminating the use of 100 metric tons of 50%
sodium hydroxide per year
• Increasing the efficiency of raw material, water and
energy use
• And, doubled the product yield.
Sertraline Process – Solvent Waste/Kg
Methanol
Ethyl acetate
Ethanol
THF
Hexane
Toluene
Methylene chloride
232 L/kg
Discovery Route
98 L/kg
1st Commercial
81 L/kg
2nd Commercial
26 L/kg
8 L/kg
3rd Commercial Chiral Tetralone
EPA’s
Presidential
Green Chemistry
Challenge Award
- 2002
How the amount of waste produced in the manufacture of sildenafil (L
of waste/kg of product) has decreased over the past 13 years.
Pyridine
Toluene
t-Butanol
2-Butanone
Ethyl Acetate
Ether
Methanol
Ethanol
Acetone
Methylene Chloride
1816 L/kg
Medicinal
Chemistry
1990
139 L/kg
Optimized
Med. Chemistry
1994
31 L/kg
Commercial Route
(1997)
10 L/kg
Commercial Route
following solvent
recovery
Who “does” green chemistry?
• Chemists
• EHS folks may assist with making the
business case and providing
inspiration/recognition, but ultimately it’s
the chemists who do this.
• Example of integration
Why Green Chemistry?
• Meets the challenge of the triple bottom
line:
– Economic
– Social
– Environmental
Green Chemistry & TBL
Economic Aspect
• Lower cost of raw materials
• Lower costs for environmental permitting and
regulatory requirements
• Lower costs on engineering controls for employee
safety
• Risk of loss due to accidents, on a macro
perspective, decreases
• Lower costs for environmental emissions control and
treatment
• Lower costs associated with inventory control
• Competitive advantage
Green Chemistry & TBL
Social Aspect
•
•
•
•
Fence line issues (odors, unplanned releases)
Resource sustainability for future generations
Public outreach/education programs
Pfizer reputation – they expect us to do this
Green Chemistry & TBL
Environmental Aspect
• More efficient use of non-renewable natural
resources
• Less impact on the environment due to
permitted wastewater discharges, air
emissions, and hazardous waste treatment
• Less risk of incidents and unplanned releases
• Smaller environmental footprint
The Nobel Prize in Chemistry 2005
The Royal Swedish Academy of Sciences
has decided to award the Nobel Prize in
Chemistry for 2005 jointly to
Yves Chauvin
Institut Français du Pétrole, RueilMalmaison, France,
Robert H. Grubbs
California Institute of Technology
(Caltech), Pasadena, CA, USA and
Richard R. Schrock
Massachusetts Institute of Technology
(MIT), Cambridge, MA, USA
“for the development of the metathesis
method in organic synthesis.”