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Τμήμα Βιολογικών Επιστημών

του Πανεπιστημίου Κύπρου στο πλαίσιο του κύκλου σεμιναρίων του, διοργανώνει διάλεξη με ομιλήτρια την

Assistant Professor Konstantinos C. Makris

Director of Water and Health laboratory, Cyprus International Institute for Environmental and Public Health

με θέμα Refining the Assessment of Environmental / Lifestyle Exposures for Improved Understanding of Chronic Disease Processes Περίληψη

The morbidity and mortality burden for the majority of non-communicable diseases [type II diabetes mellitus (T2DM), several types of cancer, etc.] can be largely attributed to a multi enable us to prevent chronic diseases lies in the elucidation of the totalities of hu Dr. Makris’ research team portfolio, wh seeks to minimize human health risks associated with low -factorial set of environmental and lifestyle risk factors. The improved understanding of such risk factors that will man exposures attributed to environment, diet, lifestyle, and endogenous processes throughout one’s lifetime during all critical stages of life; this is the definition of the human Exposome. This lecture will present ich is based upon a transition focus of efforts and resources from disease to exposure through implementation of the Exposome concept. The research team level chronic exposures to naturally occurring and man made environmental chemicals, such as those present in water and food items, packaging materials and numerous consumer products. Because of Exposome’s high dimensional and agnostic framework, the definition of metabolomics as the study of a comple te set of chemical metabolites and biological responses that result from cellular processes fits well with the underlying principles of an Exposome study. Targeted and untargeted techniques of the Exposome, such as biomonitoring protocols and metabolomics on human biofluids are utilized by the team towards the improved understanding of human exposures to environmental chemicals and their metabolic health effects. Special focus has been paid upon delineating human exposures to disinfection by products (triha lomethanes) and plasticizers [such as bisphenol A (BPA) and its chlorinated derivatives, along with BPA free alternatives] that disrupt hormonal and metabolic homeostasis

during critical windows of susceptibility. The metabolic disruptor hypothesis postula and their bio tes that environmental chemicals may be important risk factors for metabolic diseases, such as T2DM, thyroid anomalies, fatty liver disease, etc. The combination of environmental and lifestyle/behavior risk factors that were explored in human studies towards an improved understanding of insulin resistance pathophysiology will be described. A series of human studies undertaken in Cyprus, Romania, and Kuwait will be synoptically presented, including our access to large population cohorts banks from Norway, the Netherlands and Germany. Last, the way forward of the team’s research portfolio and expected synergies with complementary disciplines will be showcased.

Η διάλεξη θα πραγματοποιηθεί την Τετάρτη , 17 Φεβρουαρίου 2016

και ώρα

17:00

στο κτίριο ΧΩΔ 0 1 , αίθουσα 1 10

στην Πανεπιστημιούπολη

H διάλεξη είναι ανοιχτή στο κοινό.