1st MEETING

Transcript 1st MEETING

SCIENTIFIC PROGRAMME

1 st

MEETING

NEW HORIZONS IN THE MEDICAL AND SURGICAL TREATMENT OF BPH AND PROSTATE CANCER september 11-13, 2014

POLICLINICO TOR VERGATA FOUNDATION ROME, ITALY

European Association of Urology International Young Urological Association

Dear Colleagues and Friends, We are delighted to invite you to participate in the 1st Meeting of ITRUST (International Translational Research in Uro-Sciences Team), to be held in Rome, Italy, September 11-13, 2014.

ITRUST is an international group of “young” academic urologists interested in translational and clinical research in all fields of urology.

The meeting is co-organized by the young urologists of the Departments of Urology of both the public universities in Rome, the University of Tor Vergata and La Sapienza.

It would be a highly educational meeting, mainly directed to the young urologists, offering a wide scientific programme on the new horizons in the treatments of prostate cancer and BPH.

All the young associations of urologists (EAU-Young Urologist Office; International Young Urological Association and the European Society of Resident in Urology) have given us their active support. A very valuable international faculty will contribute to make the sessions highly interesting and interactive.

The sessions will cover all the already established and the new medical and surgical treatments of prostate cancer and BPH, among which the live surgery session will be extremely educational.

The ITRUST Award Session will give the young researchers the opportunity to present and discuss their last works and to win a very special prize.

Knowledge exchange and networking between young urologists are the main objectives of the meeting.

We encourage you to join the meeting and, last but not least, visit Rome in an amazing season!

We look forward to seeing you the next September, Roberto

Miano

Policlinico Tor Vergata Foundation University of Tor Vergata

Rome

, Italy Cosimo

De Nunzio

S.Andrea Hospital University La Sapienza

Rome

, Italy www.itrusturology.com

MEETING OBJECTIVES

ITRUST (International Translational Research in Uro-Sciences Team) is a small group of young urologists interested in translational and clinical research in different field of urology.

The purpose of this first meeting is to provide delegates with informations on the last clinical, pharmacological and surgical treatment for prostate cancer and BPO due to BPH. Many questions remain still unanswered:

1)

The traditional approach to localized prostate cancer with surgery or radiotherapy is now being in discussion due to the significant complication rate. Emerging surgical techniques are now under clinical evaluation: focal therapy is a fact or fiction?

2)

New drugs are now available for CRPC and metastatic prostate cancer: a multidisciplinary approach is advisable. What the urologists need to learn from the oncologists?

3)

Laser technology have gained great interest for BPO treatment in the last years: is the TURP era really ended?

4)

LUTS, inflammation, BPH, BPO, overactive bladder: what we know and what we still need to know of this complex interaction?

THE LIVE-SURGERY SESSION WILL SHOW DELEGATES THE LAST TECHNOLOGIES FOR THE SURGICAL TREATMENT OF PROSTATE CANCER AND BPH.

A SPECIAL ITRUST AWARDS POSTER SESSION WILL REFER THE VERY LAST CLINICAL AND TRANSLATIONAL RESEARCH OF YOUNG UROLOGISTS IN THIS FIELD.

www.itrusturology.com

1 st

MEETING

NEW HORIZONS IN THE MEDICAL AND SURGICAL TREATMENT OF BPH AND PROSTATE CANCER september 11-13, 2014

POLICLINICO TOR VERGATA FOUNDATION, ROME, ITALY

DIRECTORS:

Roberto

Mian

o , Cosimo

De Nunzio EXECUTIVE DIRECTOR OF ITRUST:

Fernando J

Kim HONORARY PRESIDENT:

Giuseppe

Vespasiani PRESIDENTIAL COMMITTEE:

Andrea

Tubaro

, Carlo

De Dominicis

, Vincenzo

Gentile SCIENTIFIC COMMITTEE:

Anastasios

Asimakopoulos

, Pierluigi

Bove

, Enrico

Finazzi Agrò

Costantino , Stefano

German

Leonardo

, Alessandro

Sciarra CONFIRMED FACULTY:

Anastasios

Asimakopoulos

, Alfredo

Berruti

, Pierluigi

Bove

, Maurizio

Brausi,

Fabio

Calabrò

, Vittore

Cereda

, Luca

Cindolo

, Enrico

Cortesi

, Sebastien

Crouzet

, Jean

De La Rosette

, Cosimo

De Nunzio

, Bob

Djavan

, Mark

Emberton

, Enrico

Finazzi Agrò

, Mauro

Gacci

, Richard

Gaston,

Bogdan

Geavlete

, Stefano

Germani

, Gianluca

Giannarini

, Paolo

Gontero

, Emre

Huri

, Christof

Kastner

, Fernando J

Kim

, Pilar

Laguna

, Costantino

Leonardo

, Paolo

Marchetti

, Roberto

Miano

, Salvatore

Micali

, Vito

Pansadoro

, Giulio

Patruno

, Bernardo

Rocco

, Mario

Roselli

, Alessandro

Sciarra

, Michiel

Sedelaar

, Cesare

Scoffone

, Cora

Sternberg

, Andrea

Tubaro

www.itrusturology.com

SEPTEMBER 11, 2014

10.00-12.00 Pre-Congress Courses

3-D LAPAROSCOPY: THE FUTURE OF RADICAL PROSTATECTOMY? Directors:

Pierluigi

Bove

- Salvatore

Micali

- Anastasios

Asimakopoulos CRYOTHERAPY FOR PROSTATE CANCER Directors:

Fernando J

Kim

- Roberto

Miano LASER FOR PROSTATE VAPORIZATION: PRINCIPLES AND TECHNIQUE Director:

Cosimo

De Nunzio

- Luca

Cindolo

14.00

14.15

Registration Welcome Directors of the Meeting

(Roberto

Miano

– Fernando J

Kim

- Cosimo De

Nunzio

)

Honorary President

(Giuseppe

Vespasiani

)

Executive Director of ITRUST

(Fernando J

Kim

)

General Manager of the Policlinico Tor Vergata

(Tiziana

Frittelli

)

Director of the Department of Experimental Medicine and Surgery, University of Tor Vergata

(Gennaro

Melino

)

ESOU

(Maurizio

Brausi

)

President Sedelaar

)

IYUA President

(Emre

Huri

)

Secretary General of SIU

(Vincenzo

Mirone

)

Rector of the University of Tor Vergata

(Giuseppe

Novelli

) www.itrusturology.com

15.00-15.20

Prostate Cancer Registries: the Italian experience

(Andrea

Tubaro

) 15.20-18.00

SESSION: ADVANCED, METASTATIC AND CASTRATE - RESISTANT PROSTATE CANCER Between hormonal manipulation, bone-targeted and chemotherapy Moderators:

Cora

Sternberg

Maurizio

Brausi

15.20-15.40

LH-RH agonist or antagonist? Continuos or intermittent therapy?

(Alessandro

Sciarra

) 15.40-16.00

16.00-16.20

16.20-16.40

Abiraterone in post-ADT: biological modifications and clinical implications

(Enrico

Cortesi

)

The actual role of chemotherapy in metastatic CRPC

(Fabio

Calabrò

)

New radiopharmaceutical in mCRPC: Radium 223 dichloride

(Paolo

Marchetti

) 16.40-17.00

Coffee Break New horizons in therapeutic strategies for advanced, metastatic and castrate-resistant cancer Moderators:

Andrea

Tubaro

- Fabio

Calabrò

17.00-17.20

Targeting the androgen receptor with Enzalutamide in mCRPC

(Alfredo

Berruti

) 17.20-17.40 17.40-18.00

New insights on the combination of immunotherapy and chemotherapy in metastatic CRPC

(Mario

Roselli

- Vittore

Cereda

)

The future of therapeutic strategies for metastatic CRPC: new drugs, new sequences or new combinations?

(Cora

Sternberg

) 6 www.itrusturology.com

SEPTEMBER 12, 2014

8.00-13.00

LIVE SURGERY (EAU endorsed event) from the Policlinico Tor Vergata Foundation Directors:

Giuseppe

Vespasiani

- Fernando J

Kim

Roberto

Miano Surgeons:

Richard

Gaston

- Fernando J

Kim

- Andrea

Tubaro

- Bogdan

Geavlete

- Sebastien

Crouzet

- Christof

Kastner Moderators:

Vito

Pansadoro

- Pilar

Laguna

- Mark

Emberton

- Bernardo

Rocco Provokers:

Pierluigi

Bove

- Costantino

Leonardo Patient Advocate:

Stefano

Germani

- Cosimo

De Nunzio Laparoscopic intrafascial radical prostatectomy Focal cryoablation of prostate cancer Vaporization of prostatic adenoma with Green Light XPS Olympus Button TURis prostate vaporization HIFU focal treatment for prostate cancer MRI/TRUS fusion transperineal prostate biopsy

13.30-14.00 14.00-17.00

Lunch SESSION: BPH Medical treatment strategies: state of the art Moderators

Enrico

Finazzi Agrò

, Alessandro

Sciarra

14.00-14.20

Alpha-blockers and 5-ARI: alone or in combination?

(Bob

Djavan

) 14.20-14.40 14.40-15.00

Antimuscarinics and beta-3-adrenergic agonist: when and how to treat the bladder in BPH patients?

(Enrico Finazzi

Agrò

)

Metabolic syndrome, inflammation, LUTS and BPH: which is the link?

(Cosimo

De Nunzio

) 15.00-15.20

15.20-15.30

The role of PDE5 in the treatment of LUTS due to BPH

(Mauro

Gacci

)

Discussion Surgical treatment strategies: state of the art Moderators:

Jean

De la Rosette

, Luca

Cindolo

www.itrusturology.com

SEPTEMBER 12, 2014

8.00-13.00

LIVE SURGERY (EAU endorsed event) from the Policlinico Tor Vergata Foundation Directors:

Giuseppe

Vespasiani

- Fernando J

Kim

Roberto

Miano Surgeons:

Richard

Gaston

- Fernando J

Kim

- Andrea

Tubaro

- Bogdan

Geavlete

- Sebastien

Crouzet

- Christof

Kastner Moderators:

Vito

Pansadoro

- Pilar

Laguna

- Mark

Emberton

- Bernardo

Rocco Provokers:

Pierluigi

Bove

- Costantino

Leonardo Patient Advocate:

Stefano

Germani

- Cosimo

13.30-14.00 14.00-17.00

Lunch SESSION: BPH Moderators

Medical treatment strategies: state of the art

Enrico

Finazzi Agrò

, Alessandro

Sciarra

14.00-14.20

Alpha-blockers and 5-ARI: alone or in combination?

(Bob

Djavan

) 14.20-14.40 14.40-15.00

Antimuscarinics and beta-3-adrenergic agonist: when and how to treat the bladder in BPH patients?

(Enrico Finazzi

Agrò

)

Metabolic syndrome, inflammation, LUTS and BPH: which is the link?

(Cosimo

De Nunzio

) 15.00-15.20

15.20-15.30

The role of PDE5 in the treatment of LUTS due to BPH

(Mauro

Gacci

)

Discussion Surgical treatment strategies: state of the art Moderators:

Jean

De la Rosette

, Luca

Cindolo

15.30-16.00

Face to face: Surgical treatment of big sized prostate adenoma TURP

(Vito )

Laser enucleation

(Cesare

Scoffone

) 16.00-16.10

Discussion

16.10-16.40

Face to face: Surgical treatment of small-medium sized prostate adenoma GreenLight

(Andrea

Laser Tubaro

)

TURis plasma vaporization Geavlete

) 16.40-16.50

Discussion

16.50-17.00

ESRU Lecture. Surgical training for BPH: results of an international survey

(Giulio

Patruno

) 17.00-18.00

ITRUST Award session on BPH and Prostate Cancer Moderators:

Bob

Djavan

- Fernando J

Kim

with Metastatic Prostate Cancer

(Meral

Huri

, Hülya

Kayıhan

) A.

Is MP-MRI Alone Sufficient In Monitoring Prostate Cancer For Patients In Active Surveillance? James

A.T.

Gooneratne

,

Bhat

, S.

Muktar

, A.

Henderson

Plasma circulating miRNAs: a new potential biomarker for prostate cancer diagnosis Giglio

, C.

De Nunzio

, F.

Presicce

, R.

Cirombella

, A.

Tubaro

, A.

Vecchione

Giampaolo 5.

Clinical Application of targeted stereotactic prostate biopsy: preliminary experience in our Martorana Bianchi

, Ahmed

Ghaith

, Riccardo

Galli

, Alessio

Zordani

, Maurizio

Paterlini

, Salvatore

Micali

Near Infrared Spectroscopy study of the bladder: a novel, non-invasive, diagnostic method of bladder outlet obstruction in men with lower urinary tract symptoms

Stefano

Masciovecchio

, Pietro

Saldutto

, Giuseppe

Paradiso Galatioto

, Carlo

Vicentini

www.itrusturology.com

SEPTEMBER 13, 2014

09.00-12.30

SESSION: LOCALIZED PROSTATE CANCER Moderators:

Pierluigi

Bove

- Costantino

Leonardo

09.00-09.20

IYUA Lecture. Periprostatic neural network in cadaveric fascial sparing radical prostatectomy

(Emre

Huri

) 09.20-09.40

ESOU Lecture. Continence-sparing anatomical landmarks during radical prostatectomy Rocco

) 09.40-10.00

EAU-YUO Lecture. Hot issues in active surveillance for prostate cancer

(Gianluca

Giannarini

) 10.00-10.20

TARGETED THERAPY FOR PROSTATE CANCER: FACT OR FICTION?

Moderators:

Pilar

Laguna

- Fernando J

Kim

10.20-10.40

Defining the ideal candidate for targeted therapy

(Roberto

Miano

) 10.40-11.00

11.00-11.15 11.15-11.30

Transrectal or transperineal, 3-D or MRI-guided: evolving prostate biopsy in the era of targeted therapy

(Christof

Kastner

)

Why Cryoablation?

(Fernando J

Kim

)

Focal treatment of prostate cancer with HIFU: principles and results

(Sebastien

Crouzet

) 11.30-11.45

11.45-12.00

12.00-12.20

12.20-12.30

IRE - update from the CROES studies

(Jean

De la Rosette

)

Vascular targeted photodynamic therapy

(Paolo

Gontero

)

Targeted therapy: where do we stand and where are we going

(Mark

Emberton

)

Discussion

12.30

Coffee break Closure remarks

www.itrusturology.com

FHOW TO REACH POLICLINICO TOR VERGATA (PTV)

The Policlinico Tor Vergata University Hospital is located in Viale Oxford 81, not far from several public transport hubs and routes. They are, in fact, near the Metro A (Anagnina), the Rome-Pantano light rail and the GRA.

By car:

T o get to the Policlinico coming from the GRA is advisable to use the outputs 17 (Tor Bella Monaca) and 20 (Romanina - Tor Vergata): - Exit 17, the hotel can be reached by using about 4 km Viale Tor Bella Monaca, follow it to the intersection with Via Cambellotti, (on the right see the steeple of the Church of Tor Bella Monaca) and follow the signs to the University Tor Vergata Policlinico Tor Vergata; - Exit number 20, the Hospital can be reached by following the signs “Romanina - Tor Vergata” and later for the hospital.

Coming from the A1 Rome-Naples can use the output of Torrenova (the first after the toll Rome South), take Via Passo Lombardo and follow the signs to the University of Tor Vergata University and Hospital.

Public transport:

The lines 20 lim, 059 and 506, with terminal directly to the Policlinico Tor Vergata 20 The line deviates to the Policlinico Tor Vergata The lines run from 20:20 lim Anagnina station (arrivals side Cotral-Metro) www.itrusturology.com

FHOW TO REACH POLICLINICO TOR VERGATA (PTV)

By plane:

From the international airport of Rome Fiumicino Leonardo da Vinci may serve the Leonardo Express train from the airport that leads to Rome Termini station Fs. From there you can choose between different solutions: - Use the Metro to Anagnina. From there take a bus lines available - Make use of the line-Fs Rome Frosinone, stop at the station of Tor Vergata, from there use the free shuttle bus From Ciampino airport you can reach by bus (every 20 ‘), the Ciampino Railway Station. From there go to Anagnina /Casal Morena and take bus 506. Get off at Tor Vergata / Pisoni which is located a short distance from the hospital.

By bus:

Those arriving by bus at the interchange of Roma Tiburtina can reach the Policlinico Tor Vergata taking the Metro B to Tiburtina to Termini and then the A from Termini to Anagnina. At that point, can choose one of the available lines There are also two direct connections to the PTV departing from Ciampino and Frascati managed by Schiaffini Travel

By train:

For those arriving by train at Termini Station the easiest way to get to the Policlinico Tor Vergata is to use the Metro and go to Anagnina. From there, use one of the available lines. 12

By car:

Public transport:

Organizing Secretariat:

I.D.S. SpA 20, Via dell'Antracite - 00157 Rome, Italy tel. +39 06 4505503 - 06 41792581 www.itrusturology.com

[email protected]

Provider ECM n. 3897:

Italymeeting s.r.l.

ECM n.

3897-94734