Transcript Drug-induced psychomimetic symptoms as a model for psychosis

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The handle http://hdl.handle.net/1887/24988 holds various files of this Leiden University
dissertation
Author: Hendrik Daniël Kleinloog-Fernández González,
Title: drug-induced psychomimetic effects as a model for psychosis
Issue Date: 2014-04-01
drug-induced psychomimetic effects
as a model for psychosis
proefschrift
Drug-induced
psychomimetic effects
as a model for psychosis
proefschrift
ter verkrijging van de graad van Doctor aan de Universiteit Leiden,
op gezag van de Rector Magnificus prof. mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties,
te verdedigen op dinsdag 1 april 2014,
klokke 16:15 uur
door
Hendrik Daniël Kleinloog-Fernández González,
geboren te ’s-Hertogenbosch in 1983
promotiecommissie
promotores
Prof. dr. J.M.A. van Gerven
Prof. dr. A.F. Cohen
overige leden
Prof. dr. M. Danhof (farmacologie)
Prof. dr. A. Dahan (anesthesiologie)
Prof. dr. J. van Os (Universiteit Maastricht, psychiatrie)
design
Caroline de Lint, Voorburg ([email protected])
isbn/ean
978-94-91997-00-6
acknowledgements
The publication of this thesis was financially supported by the
foundation Centre for Human Drug Research (chdr), Leiden, the
Netherlands, and the Tergooi hospital, Hilversum, the Netherlands
9
chapter 1
Introduction
23
chapter 2
Does olanzapine inhibit the psychomimetic effects of thc?
53
chapter 3
Profiling the subjective effects of thc using visual analogue scales
79
chapter 4
The influence of personality on the sensitivity to subjective effects of thc
107
chapter 5
Optimizing the glutamatergic challenge model for psychosis: using
S(+)-ketamine to induce psychomimetic symptoms in healthy volunteers
139
chapter 6
Development and evaluation of a new visual analogue scale for
psychedelic effects
153
chapter 7
Subjective effects of ethanol, morphine, thc and ketamine
following a pharmacological challenge are related to functional
brain connectivity
173
chapter 8
Discussion
189
201
215
216
Summary
Samenvatting / Summary in Dutch
Curriculum Vitae
List of publications