Transcript DON'T THINK ABOUT A WHOLE ORGANISM: FRAMING THE QUESTION IN SCIENCE DON MIKULECKY PROFESSOR EMERITUS OF PHYSIOLOGY AND SENIOR FELLOW IN THE CENTER FOR THE.

DON'T THINK ABOUT A WHOLE
ORGANISM: FRAMING THE
QUESTION IN SCIENCE
DON MIKULECKY
PROFESSOR EMERITUS OF PHYSIOLOGY AND
SENIOR FELLOW IN THE CENTER FOR THE STUDY
OF BIOLOGICAL COMPLEXITY-VCU
http://www.people.vcu.edu/~mikuleck/
WHAT IS “FRAMING THE
QUESTION”?
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Based on the work of George Lakoff
Cognitive Linguistics
Frames are the mental structures that
shape the way we see the world
Facts, data, models, etc. only have
meaning in a context
Leads us to a scientific application of
framing : Rosen’s theory of complexity
Framing the question
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Don’t think of an elephant
Impossibility of avoiding the frame
In science the dominant frame is
reductionism and the associated
mechanical thinking
The dominant modern manifestations
include molecular biology and nonlinear
dynamics
An Example of Reframing the question to get an answer : The
work of Robert Rosen
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What is life?
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Why is an organism different from a
machine?
THE MODELING RELATION: A MODEL OF HOW WE MAKE
MODELS, A SCIENCE OF FRAMING
NATURAL
SYSTEM
ENCODING
CAUSAL
EVENT
MANIPULATION
DECODING
NATURAL
SYSTEM
FORMAL
SYSTEM
FORMAL
SYSTEM
WE HAVE A USEFUL MODEL
WHEN
ARE SATISFACTORY WAYS OF “UNDERSTANDING”
THE CHANGE IN THE WORLD “OUT THERE”
THE MODELING RELATION: A MODEL
OF HOW WE MAKE MODELS
NATURAL
SYSTEM
ENCODING
CAUSAL
EVENT
IMPLICATION
DECODING
NATURAL
SYSTEM
FORMAL
SYSTEM
FORMAL
SYSTEM
WHAT “TRADITIONAL SCIENCE” DID TO FRAME THE
MODELING RELATION
FORMAL
SYSTEM
NATURAL
MANIPULATION
SYSTEM
CAUSAL
EVENT
FORMAL
SYSTEM
NATURAL
SYSTEM
WHAT “TRADITIONAL SCIENCE” DID TO FRAME THE
MODELING RELATION
FORMAL
NATURAL
SYSTEM
SYSTEM
MANIPULATION
FORMAL
NATURAL
SYSTEM
SYSTEM
WHY WHAT “TRADITIONAL SCIENCE” DID TO THE
MODELING RELATION MADE THE PRESENT SITUATION
INEVITABLE:
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WE MORE OR LESS FORGOT
THAT THERE WAS AN
ENCODING AND DECODING
WHY WHAT “TRADITIONAL SCIENCE” DID TO THE
MODELING RELATION MADE THE PRESENT SITUATION
INEVITABLE: IT FRAMED THE QUESTIN
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THE “REAL WORLD” REQUIRES
MORE THAN ONE “FORMAL
SYSTEM” TO MODEL IT (THERE
IS NO “UNIVERSAL MODEL”)
WHY WHAT “TRADITIONAL SCIENCE” DID TO THE
MODELING RELATION MADE THE PRESENT SITUATION
INEVITABLE:
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WE ARE TOO AFRAID OF
“BELIEFS” (SCEPTICISM IS “IN”)
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WE DEVELOPED THE MYTH OF
“OBJECTIVITY”
WHAT IS SCIENCE?
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HAS MANY DEFINTIONS
SOME OF THESE ARE IN CONFLICT
SCIENCE IS A BELIEF STRUCTURE
SCIENCE OF METHOD VS SCIENCE OF
CONTENT
WHY IS “OBJECTIVITY” A MYTH? (OR: WHY IS SCIENCE
A BELIEF STRUCTURE)
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THE FORMAL SYSTEM DOES NOT AND CAN
NOT TELL US HOW TO ENCODE AND
DECODE. (MODELING IS AN ART!)
THE FORMAL SYSTEM DOES NOT AND CAN
NOT TELL US WHEN THE MODEL WORKS,
THAT IS A JUDGEMENT CALL EVEN IF
OTHER FORMALISMS ARE ENLISTED TO
HELP (FOR EXAMPLE: STATISTICS)
MODELS EXIST IN A CONTEXT: A FRAME
WHY ARE THERE SO MANY
DEFINITIONS OF COMPLEXITY?
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SCIENTISTS FOCUS ON THE FORMAL
DESCRIPTION RATHER THAN THE
REAL WORLD
THE REAL WORLD IS COMPLEX
FORMAL SYSTEMS COME IN VARYING
SHADES AND DEGREES OF
COMPLICATION
WHAT ARE SOME OF THE THINGS THAT MAKE
“COMPLEXITY THEORY” NECESSARY? (WHAT HAS
“TRADITIONAL SCIENCE” FAILED TO EXPLAIN?)
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WHY IS THE WHOLE MORE THAN THE
SOME OF THE PARTS?
SELF-REFERENCE AND CIRCULARITY
THE LIFE/ORGANISM PROBLEM
THE MIND/BODY PROBLEM
Reductionism has framed
complexity theory
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Rather than change methods we have the changed
names for what we do
The consequences are significant
It is impossible for you to believe what is being
taught in this lecture and to then simply add it to
your repertoire
The reason is that in order to see the world in a new
way you have to step out of the traditional frame and
into a new one. Once done, you can never go back.
The ability to reframe a question is the basis for
change and broadening of ideas.
WHAT IS COMPLEXITY?
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TOO MANY DEFINITIONS, SOME
CONFLICTING
OFTEN INTERCHANGED WITH
“COMPLICATED”
HAS A REAL MEANING BUT AFTER THE
QUESTION IS REFRAMED
THAT MEANING ITSELF IS COMPLEX(THIS IS
SELF-REFERENTIAL: HOW CAN WE DEFINE
“COMPLEX” USING “COMPLEX”?)
ROSEN’S CONCEPT FOR
COMPLEXITY: A NEW FRAME
Complexity is the property of a real world
system that is manifest in the inability of any
one formalism being adequate to capture all
its properties. It requires that we find
distinctly different ways of interacting with
systems. Distinctly different in
the sense that when we make successful
models, the formal systems needed to
describe each distinct aspect are NOT
derivable from each other
The Mexican sierra [fish] has "XVII-15-IX" spines
in the dorsal fin. These can easily be counted ...
We could, if we wished, describe the sierra thus:
"D. XVII-15-IX; A. II-15-IX," but we could see the
fish alive and swimming, feel it plunge against
the lines, drag it threshing over the rail, and
even finally eat it. And there is no reason why
either approach should be inaccurate.
Spine-count description need not
suffer because another approach is also used.
Perhaps, out of the two approaches we thought
there might emerge a picture more complete and
even more accurate that either alone could
produce.
-- John Steinbeck, novelist,
with Edward Ricketts, marine biologist (1941)
COMPLEX SYSTEMS VS
SIMPLE MECHANISMS
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COMPLEX
NO LARGEST MODEL
WHOLE MORE THAN SUM
OF PARTS
CAUSAL RELATIONS RICH
AND INTERTWINED
GENERIC
ANALYTIC  SYNTHETIC
NON-FRAGMENTABLE
NON-COMPUTABLE
REAL WORLD
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SIMPLE
LARGEST MODEL
WHOLE IS SUM OF PARTS
CAUSAL RELATIONS
DISTINCT
N0N-GENERIC
ANALYTIC = SYNTHETIC
FRAGMENTABLE
COMPUTABLE
FORMAL SYSTEM
CIRCULARITY (SELF-REFERENCE)
CAUSES PROBLEMS FOR LOGIC AND
SCIENCE
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I AM A CORINTHIAN
ALL CORINTHIANS ARE LIARS
OR
“THE STATEMENT ON THE OTHER
SIDE IS FALSE”-ON BOTH SIDES
CAN WE GET RID OF SELF-REFERENCE,
THAT IS, CIRCULARITY?
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IT HAS BEEN TRIED
IT FAILED
THE ALTERNATIVE IS TO “GO
AROUND” IT – THAT IS TO IGNORE
CASES WHERE IT POPS UP
WHAT IF IT IS VERY COMMON?
SELF-REFERENCE, CIRCULARITY
AND THE GENOME
REPLICATION
TRANSCRIPTION
HOMEOSTASIS
WHERE DO CELLS COME
FROM?
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DNA?
GENES?
PROTEINS?
OTHER CELLS?
SPONTANEOUS GENERATION?
THE CELL THEORY
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CELLS COME FROM OTHER CELLS
WHY WHAT “TRADITIONAL SCIENCE” DID TO THE
QUESTION MADE THE PRESENT SITUATION
INEVITABLE:
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THE MACHINE METAPHOR
TELLS US TO ASK “HOW?”
REAL WORLD COMPLEXITY
TELLS US TO ASK “WHY?”
THE FOUR BECAUSES: WHY A
HOUSE?
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MATERIAL: THE STUFF IT’S MADE OF
EFFICIENT: IT NEEDED A BUILDER
FORMAL: THERE WAS A BLUEPRINT
FINAL: IT HAS A PURPOSE
WHY IS THE WHOLE MORE THAN THE SOME OF THE
PARTS?
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BECAUSE REDUCING A REAL SYSTEM
TO ATOMS AND MOLECULES LOOSES
IMPORTANT THINGS THAT MAKE THE
SYSTEM WHAT IT IS
BECAUSE THERE IS MORE TO
REALITY THAN JUST ATOMS AND
MOLECULES (ORGANIZATION,
PROCESS, QUALITIES, ETC.)
SELF-REFERENCE AND CIRCULARITY
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THE “LAWS” OF NATURE THAT
TRADITIONAL SCIENCE TEACHES ARE
ARTIFACTS OF A LIMITED MODEL
THE REAL “RULES OF THE GAME”
ARE CONTEXT DEPENDENT AND
EVER CHANGING- THEY MAKE THE
CONTEXT AND THE CONTEXT MAKES
THEM (SELF-REFERENCE)
EXAMPLE: THE LIFE/ORGANISM PROBLEM
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LIFE IS CONSISTENT WITH THE LAWS
OF PHYSICS
PHYSICS DOES NOT PREDICT LIFE
LIVING CELLS COME FROM OTHER
LIVING CELLS
AN ORGANISM MUST INVOLVE
CLOSED LOOPS OF CAUSALITY
LIFE DOES INVOLVE PURPOSE
PROBLEM
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HOW CAN THE MIND MODEL ITSELF?
AM I CONSCIOUS?
HOW DOES THE BRAIN PRODUCE
CONSCIOUSNESS, SELF AWARENESS,
ETC.?
CONCLUSIONS
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THE REAL WORLD IS COMPLEX
THE WORLD OF “SIMPLE MECHANISMS” IS A
SURROGATE WORLD CREATED BY TRADITIONAL
SCIENCE
WE ARE AT A CROSSROADS: A NEW WORLDVIEW
IS NEEDED
THERE WILL ALWAYS BE RISK ASSOCIATED WITH
ATTEMPTS TO PROGRESS
YOUR CRYSTAL BALL MAY BE AS GOOD AS MINE
OR BETTER
POST SCRIPT
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WE LIVE IN A WORLD DOMINATED BY COMPUTERS
MOST COMPLEXIFIERS BELIEVE THAT
COMPLEXITY IS SOMETHING WE CAN DEAL WITH
ON THE COMPUTER
THIS NOTION OF COMPLEXITY FOCUSES ON THE
MECHANICAL ASPECTS OF THE REAL WORLD
WHAT MAKES THE REAL WORLD COMPLEX IS ITS
NON-COMPUTABILITY