Transcript James P. Kiley, Ph.D. National Heart, Lung, and Blood Institute U.S. Department of Health and Human Services Orientation to NIH National Institutes of Health National Heart, Lung, and Blood.

James P. Kiley, Ph.D.
National Heart, Lung, and Blood Institute
U.S. Department of
Health and Human
Services
Orientation to NIH
National Institutes
of Health
National Heart, Lung,
and Blood Institute
May 21, 2005
National Institutes of Health
Much of the
biomedical
research in the
United States is
supported by the
Federal
Government,
primarily the
National Institutes
of Health (NIH)
NIH Mission
Acquire new knowledge that will lead to
better health for everyone
• Support research
• Train young investigators
• Communicate research results
to the medical community and the
public
FY 2005 Funding By Mechanism
(dollars in billions)
TOTAL BUDGET
$28.8 Billion
Spending at NIH
$4.7
Spending Outside NIH
16% NIH In-House
6,000 Scientists
$2.8 Intramural = 10%
$1.0 RM&S = 4%
$0.9 Other (NLM, OD, et
al.) = 3%
84% Outside NIH
(Supports over 212,000
Scientists & Other Personnel)
(Supports over 3,000
Institutions Nationwide)
$24.1
NIH comprises 27 Institutes and Centers
National Institutes of Health
Office of the Director
National Eye
Institute
National Heart,
Lung, and Blood
Institute
National Human
Genome Research
Institute
National Institute
on Aging
National Institute
on Alcohol Abuse
and Alcoholism
National Institute
of Allergy and
Infectious
Diseases
National Institute
of Arthritis and
Musculoskeletal
and Skin Diseases
National Institute
of Biomedical
Imaging and
Bioengineering
National Institute
of Child Health
and Human
Development
National Institute on
Deafness and Other
Communication
Disorders
National Institute
of Dental and
Craniofacial
Research
National Institute
of Diabetes and
Digestive and
Kidney Diseases
National Institute
on Drug Abuse
National Institute
of Environmental
Health Sciences
National Cancer
Institute
National Institute
of General
Medical Sciences
National Institute
of Mental Health
National Institute
of Neurological
Disorders and
Stroke
National Institute
of Nursing
Research
NIH Home Page - www.nih.gov
• NIH Guide
• Grant Policy
• Applications
• Additional Program
Information
• Staff Contacts
NIH Extramural Programs
Grant
Patron
(assistance, encouragement)
Cooperative
Agreement
Partner
(assistance but substantial
program involvement)
Contract
Purchaser
(procurement)
Investigator-Initiated Research and
Research Training Opportunities
• R01: Regular Research
• P01: Program Project
• SBIR: Small Business Innovative
Research
• K-series: Career Awards
• NRSA: Fellowships and Training
Grants
Opportunities for “Young” Investigators
• National Research Service Individual Fellowship (F32)
• Mentored Research Scientist Development Award
(K01)
• Independent Scientist Award (K02)
• Mentored Clinical Scientist Development Award (K08)
• Small Grant (R03)
• Academic Research Enhancement Award (R15)
• Exploratory/Developmental Grant (R21)
• Loan Repayment Program (L30 and L40)
NIH Grant Process
Identifies Career Goal and
Prepares Application
Training and
Research
Investigator
Submit Application
Grantee
Institution
Manages Funds
National Institutes of Health
Center for Scientific Review
assigns application to
Initial Review Group (IRG)
and Institute
IRG
evaluates
scientific
merit
Institute
Advisory Council
recommendation
Institute makes
funding decision
and issues
Award
PHS Research Grant
Application Kit (form PHS 398)
Mail Completed Forms To:
CENTER FOR SCIENTIFIC REVIEW
NATIONAL INSTITUTES OF HEALTH
ROCKLEDGE II ROOM 1040 MSC7710
BETHESDA MD 20892-7710
http://grants.nih.gov/grants/funding/phs398/phs398.html
Dual Review System for Grant Applications
First Level of Review
Scientific Review Group (SRG)
 Provides Initial Scientific Merit
Review of Grant Applications
 Rates Applications and Makes
Recommendations for Appropriate
Level of Support and Duration of Award
Second Level of Review
Council
 Assesses Quality of SRG
Review of Grant Applications
 Makes Recommendation to
Institute Staff on Funding
 Evaluates Program Priorities
and Relevance
 Advises on Policy
Receipt and Review
• Standard Receipt Dates for Competing
Applications
(http://grants2.nih.gov/grants/funding/submi
ssionschedule.htm)
• Review Guidelines of Research Grants
(http://www.csr.nih.gov/cdg/cd%20guidelines
/r01_Research_Grants.pdf)
• NIH Grant Review Process Video
(http://www.csr.nih.gov/video/video.asp)
Applications are Assigned to:
• Scientific review groups based on:
– Specific review guidelines for each scientific
review group
– Applicants may indicate preference as to Institute
and SRG assignment in cover letter
• Institutes based on:
– Overall mission of the Institute and referral
guidelines
– Specific programmatic mandates and interests of
the Institute
Review of Research Grants
Review Criteria:
– Significance
– Approach
– Innovation
– Investigator
– Environment
– Overall Evaluation & Score
Reflects Impact on Field
Scientific Review Group Actions
• Scored, Scientific Merit Rating
(priority scores and
percentiles)
• Unscored (lower half)
• Deferral
STUDY SECTIONS DO NOT FUND
INSTITUTES FUND!
Research Training and
Career Development
Research Training and Development
Graduate Student
Pre-doctoral Training
Support (T32)
Research Project
Grant (R01)
Senior
Fellowship
(F33)
Postdoctoral
Training Support
(T32, F32)
Graduate
Student
Stages of
Research Training
and Development
PostDoc.
Career
MidCareer
Change
Research Training and Development
Medical Student
Mentored Clinical Scientist
Development Award (K08)
Short-term Training of
(K23)
(K24)
Health Professional
Students (T35)
Research
Senior
Project
Postdoctoral
Fellowship
Grant
(R01)
Training Support
(F33)
(T32, F32)
Medical
Stages of
Student
Research Training
and Development
Internship
Residency
PostDoc.
Career
MidCareer
Change
Institute-Initiated Research
• Targeted (<25% of extramural funds)
• Usually time-limited (4 yrs) unless reannounced
• Institute Specifies:
Area of Research, Research Goals, Funds
Allocated, Research Design, and Length of
program (Program Announcements;
Requests for Applications or Proposals)
Program Announcements (PAs)
• Invites grant applications in a given research area
• May describe new or expanded interest in a
particular extramural program
• May be a reminder of a continuing interest in a
particular extramural program
• Generally has no funds set aside
• Applications reviewed in CSR along with
unsolicited grant applications
Requests for Applications (RFAs)
• Announcement describing an institute initiative in
a well-defined scientific area
• Invitation to the field to submit research grant
applications for a one-time competition
• Set-aside of funds for a certain number of awards
• Applications generally reviewed within the
issuing institute
NIH Guide for Grants and Contracts
NHLBI Home Page – www.nhlbi.nih.gov