Transcript Working Group on Effects, 29th Session, 22-24 September 2010 Task Force on Health: Results: ozone ECE/EB.AIR/WG1/2010/11 Michal Krzyzanowski TFH Chair WHO/Europe, European Centre for Environment and.

Working Group on Effects, 29th Session, 22-24 September 2010
Task Force on Health:
Results: ozone
ECE/EB.AIR/WG1/2010/11
Michal Krzyzanowski
TFH Chair
WHO/Europe, European Centre for Environment and Health, Bonn
http://www.euro.who.int/air
Effects of O3 exposure on health: 2010 update
• New studies confirm short term effects of O3 exposure &
conclusions of WHO AQG Global Update 2005
• Emerging new evidence on health effects of long term exposure
• Studies on pathological mechanisms focused on O3 effect
modification by polymorphisms in antioxidant genes, molecular
mechanisms associated with vascular disease and
oxidation/interaction of surfactant and airway nerves.
Effects of long term O3 exposure
Risk of asthma hospital admissions in children and
mean O3 in 1995-1999, adjusted for main confounders.
Lin et al, EHP 2008
Effects of long term O3 exposure
Exposure-response curve for relation between long term O3
exposure and risk of death due to respiratory causes. Results of
analysis of ACS cohort of 448,000 adults followed for up to 18
years
RR per 10 ppb = 1.040 (95% CI 1.010 - 1.067)
(2-pollutant model with O3 and PM2.5)
Jerrett et al, NEJM 2009
O3 trends in Europe, 1999-2008
O3 annual mean
trend (%/yr)
1999-2008
all stations
<-2 %/yr
-2 - 0 %/yr
0 - 2 %/yr
> 2 %/yr
source: ETC/ACC- AIRBASE
April -2010
Impact indicators in 2020 vs. levels in 2000, for the baseline cases
and the maximum technical feasible reductions (MTFR)
Amman et al, CIAM Report 1/2010
Based on SOMO35