Transcript Kathleen Casey-Kirschling Born January 1, 1946 YOUNG CHILDREN AND OLDER PEOPLE AS A PERCENTAGE OF GLOBAL POPULATION PROJECTED INCREASE IN GLOBAL POPULATION BETWEEN 2005 and 2030, BY.

Kathleen Casey-Kirschling
Born January 1, 1946
YOUNG CHILDREN AND OLDER
PEOPLE AS A PERCENTAGE OF
GLOBAL POPULATION
PROJECTED INCREASE IN
GLOBAL POPULATION
BETWEEN 2005 and 2030,
BY AGE
United Nation Department of Economic and Social Affairs, Population Division.World Population Prospects. The
2004Revision. New York: United Nations, 2005 in Why Population Aging Matters: A Global Perspective at
www.nia.nih.gov/ResearchInformation/ExtramuralPrograms/BehavioralAndSocialResearch/GlobalAging.htm
ed
i
U.
S.
60
Cu
rr
en
t
19
00
)
.(
la
nd
28
U.
S
ng
ev
al
E
Ro
m
e
al
40
M
Cl
as
si
ca
l
Ne
an
de
rth
Increases in Life Expectancy
100
80
77.9
47.3
33
20
20
0
Age and Risk of Chronic Disease
Source: National Vital Statistics Report, Vol. 50, No. 15, September 16, 2002
Alzheimer’s Disease Projections: Incidence,
Cost of Care, and Federal Research Funding
Cost of Care
People in US with
Alzheimer’s
Sources: Alzheimer’s Study Group, A National Alzheimer’s Strategic Plan: The Report of the Alzheimer’s Study Group
(March 2009); Alzheimer's Association, Changing the Trajectory of Alzheimer's Disease: A National Imperative (May 2010);
National Institutes of Health Office of the Budget website.
Treatments in Development:
Nearly 100 for Alzheimer’s and other Dementias
Source: PhRMA New Medicines in Development for Neurological Disease (November 2010)
Select Failed Alzheimer’s Disease
Treatment Trials
Treatment
Result
Dimebon
Negative
Rosiglitazone
Negative
Semagacestat
Negative
Tarenflurbil
Negative
Tramiprosate
Negative
Xaliprodan
Negative
Lifecycle of Alzheimer’s Disease:
Where We Intervene
Source: Jack et al, Brain 2009
Lifecycle of Alzheimer’s Disease:
Where We Intervene
Source: Jack et al, Brain 2009
Lifecycle of Alzheimer’s Disease:
Where We Intervene
Source: Jack et al, Brain 2009
Alzheimer’s Disease Treatment
Development
Promising biomarkers:
• Amyloid Imaging
• CSF Proteins
• Genetics
• Volumetric MRI and Hippocampal Shrinkage
Getting FDA to Respond
Alzheimer’s Disease Biomarker Working Group
•
•
•
•
•
•
•
•
•
•
•
Dennis Selkoe (Harvard), Co-Chair
John Morris (Wash U., St. Louis), Co-Chair
Cliff Jack (Mayo), Structural Neuroimaging
Bill Klunk (Pittsburgh), Amyloid Imaging
Reisa Sperling (BWH/Harvard), FMRI
Dave Holtzman (Wash U., St. Louis), CSF
Marliyn Albert (Johns Hopkins), Cognitive testing
Richard Mayeaux (Columbia), Genetics
Paul Aisen (UCSD/ADCS), Clinical trials
Eric Reiman (U. Ariz., BannerHealth), FDG PET
John Trojanowski (Penn), ADNI core
Getting FDA to Respond
Members
•
•
•
•
•
Alliance for Aging Research (AAR)
Alzheimer's Foundation of America (AFA)
American Society on Aging (ASA)
National Alliance for Caregiving (NAC)
National Association of Area Agencies on Aging
(n4a)
• National Consumers League (NCL)
• Research!America
• Society for Women's Health Research
Getting FDA to Respond
Members (Cont.)
•Abigail Alliance
•Academy of Correctional Health Professionals
•Alzheimer’s Drug Discovery Foundation
•American Academy of Ambulatory Care Nursing (AAACN)
•American Academy of Neurology
•American Association for Geriatric Psychiatry (AAGP)
•American Association of Colleges of Nursing
•American Federation for Aging Research (AFAR)
•American Health Assistance Foundation
•American Medical Students Association (AMSA)
•American Medical Women's Association (AMWA)
•American Nurses Association (ANA)
•American Psychological Association (APA)
•American Public Health Association
•American Society of Consultant Pharmacists (ASCP)
•Association of Jewish Aging Services (AJAS)
•B'nai B'rith International
•Blanchette Rockefeller Neuroscience Institute
•Business and Professional Women/USA
•Center for the Advancement of Health
•Faster Cures
Getting FDA to Respond
Members (Cont.)
•Gerontological Society of America (GSA)
•Hadassah
•International Eye Foundation (IEF)
•International Longevity Center - USA (ILC-USA)
•Men's Health Network (MHN)
•National Academy of Elder Law Attorneys
•National Asian Pacific Center on Aging
•National Association for Home Care
•National Association of Senior Companion Project Directors
•National Business Group on Health
•National Commission on Correctional Health Care
•National Council on Patient Information and Education (NCPIE)
•National Electrical Manufacturers Association (NEMA)
•National Indian Council On Aging
•National Mental Health Association
•National Palliative Care Research and Training Center (NPCRTC)
•National Partnership for Women & Families
•National Senior Citizens Law Center
•National Women's Health Network
•Older Women's League (OWL)
•RetireSafe
•Strategic Health Policy International (SHPI)
Getting FDA to Respond
Other Major Efforts:
• Alzheimer’s Disease Neuroimaging Initiative
(ADNI)
• Coalition Against Major Diseases (CAMD)
• NIA-Alzheimer’s Association Project to
Redefine Diagnostic Criteria for Alzheimer’s
Disease
More About the Science of Alzheimer’s
Disease
Published in July 2010. Available by contacting: [email protected] or [email protected]