Principles of Immunology The Inflammatory Process 4/6/06 "Life is not measured by the number of breaths we take, but by those special moments that.
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Transcript Principles of Immunology The Inflammatory Process 4/6/06 "Life is not measured by the number of breaths we take, but by those special moments that.
Principles of Immunology
The Inflammatory Process
4/6/06
"Life is not measured by the number of breaths we
take, but by those special moments that take our
breath away."
Anonymous
Word/Terms List
Acute phase proteins
Cell adhesion molecules
Chemotaxis
HEVs
ICAMs
Integrins
Mucins
Selectins
Inflammatory Process
A localized tissue response
Triggered by trauma and/or antigenic
insult
May include systemic effects
Characterized by redness, heat,
swelling, and pain
Principal cells are leukocytes and
macrophages
Cell Adhesion Molecules (CAMs)
Required for extravasation
Neutrophil extravasation
Lymphocyte extravasation
Cell Adhesion Molecules (CAMs)
Selectins
Mucins
Proteins
Present CHO ligands to selectins
Present on endothelial cells and neutrophils
Integrins
Glycoproteins
Bind to carbohydrates
Expressed on leukocytes and endothelial cells
Proteins; heterodimers
Expressed on leukocytes
Bind to Ig superfamily molecules
ICAMs
Ig CAMs
Expressed on endothelial cells
Bind to integrins
Margination and Extravasation
Rolling
Activation
Arrest
Transendothelial migration
Overview of Inflammation
Cells involved
Mediators
Histamine
Cytokines
Kinins
Vascular changes
Monocytes/macrophages
Neutrophils
Dilation
Increased permeability
Complement
Effects of Macrophage Cytokines
IL-1, IL-6, TNF alpha
Pyrogenic
Vascular permeability
Expression of CAMs
T and B cell activation
Ig synthesis
Systemic Changes
Fever
Acute phase proteins
Leukocytosis
Interferon Effects
T Helper induction
Macrophage activation
MHC expression
NK cytotoxicity
B cell activation
Lymphocyte Extravasation
Naïve lymphocytes
Occurs in secondary lymphoid organs
Occurs in high endothelial venules
(HEVs)
Lymphocte homing