GI/Autoimmune Case Study Sunday January 18, 2015 Health History • Client: • 53 yr old female • Upper and lower GI bloating • Varied stool consistency • • Float -> GB Cold extremities • Thermography –

Transcript GI/Autoimmune Case Study Sunday January 18, 2015 Health History • Client: • 53 yr old female • Upper and lower GI bloating • Varied stool consistency • • Float -> GB Cold extremities • Thermography –

GI/Autoimmune Case Study Sunday January 18, 2015 1

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Health History

Client : 53 yr old female Upper and lower GI bloating • Varied stool consistency Float -> GB • Cold extremities Thermography – blue hands/feet Hair loss Fatigue Anxiety • Genetic Family (father’s side) • Father – Dementia; Antibodies to: – Myelin Basic Protein IgG + IgA – Asialoganglioside IgG + IgA – Alpha + Beta Tublin IgG + IgA • Very high • First Cousins and Sister – Crohns - RA • Aunt – Non-Hodgkins Lymphoma • PGM- Suspected Glomerular disease 2

SNP Guideposts

• GI:

Many IgA & FUT2

– Crohns in family and cousins • Folate: MTHFR/SLC19A1 • B12: GIF / TCN1/MTR/MTRR –

High MCV

• Thyroid: CTLA/FOXE1 • Upper GI : COMT, SULT2A1, – Mito: COX, NDUF • Anxiety: GAD • High Sympathetic NS (adrenaline):

COMT H26H & V158M homozygous

• Other Immune : APOE4, ATG16L1, IL-13, STAT4,TNF-308 3

Braking System, Neuro/Adrenals

• (5/2013) • Cortisol – Kick up in late-evening – Tired in the am – “Second wind” after afternoon dip – Early stage adrenal fatigue • Neurotransmitter biomarkers: » In range – Serotonin, Taurine, Histamine, Epi » Low – GABA (GAD), PEA, DOPAC » High – Glutamate (GAD), Dopamine, Nor-epi (COMT) 4

Braking System, GI

• (2/2013) • High Campylobacter • High Clostridia • Positive Blastocystis hominis • +2 Saccharomyces • High Fecal sIgA • High Anti-gladin sIgA • NOTE: Heidlelberg test could not be completed, as pH never dipped below 2 to invoke challenge.

• Low Elastase • High triglycerides • History of severe upper GI pain on BCPs, going back to mid 20’s.

– Sharp pain, fetal position, no tolerance to liquid/food – Migraines, vomiting 5

Add notes about three flavors of zonulin

Leaky Gut

Foods; not chemicals

Some Clues

Some Polypeptides that cross-react and act as Gluten; Molecular Mimicry 8

Antibodies In Play

Father

From: Subject: Date: To:

[email protected]

December 31, 2014 at 7:58 PM [email protected]

Check for Oxalate Issues

Check for Oxalate Issues, con’t

Markers for High Oxalates

– High Oxalic acid, Glyceric acid, and/or Glycolic acid • Genetic predisposition, OR • Leaky gut – High Arabinose • Possible low Lactobacillus when oxalates excessive – Low Vit B6 • Cofactor for oxalate degrading enzymes •

Lysine required for P5P docking and activation

• http://www.qiagen.com/us/products/genes%20and%20pathways/pathway%20details.aspx?pwid=274 – Low Vit C (oxidizes to oxalates) • In the presence of high free Cu and/or Fe – Low Zn (bounded-up by oxalates) 13

Balancing GI

• Remove gluten – Check for leaky gut, cross reactivity food antibodies, metal antibodies • Remove foods • Upper GI Suport – Betaine HCl, Pancreatic enzymes, Ox Bile • Metronidazole 10 days (further evidenced by OATs) • Probiotics (Blend and Lactobacillus rhamnosus), SCFAs, Mg glycinate • Zn carnosine • Adrenal, thyroid panel • Support bile production and estrogen clearing 14

Balancing Neurotransmitter markers; Initial

• Time released 5-HTP • Phenylated-GABA • Dietary changes • 3 Phase approach – Phase I – Braking system • AM Smoothie with GI assistance • Foundational support: B Minus, MultiMin, ALA, LipoC, Lithium orotate – Phase II – Braking system • Address estrogen clearing with Calcium-d-Glucarate, DIM and ammonia clearing via NA K Butyrate, (CBS and low Vit B6 due to high previous oxalate diet) – Phase III - Accelerator • Layer in hydroxy B12 and 5MTHF and Folinic acid 15

Of Course

• Reduce high oxalate foods – Leaky Gut – Switch Mg glycinate to Mg citrate • Eliminate Grains (except limited rice and corn) , Dairy, Yeast, Soy, Egg • Rotate protein sources 16

Recap Plan

• Address GI (Phase I) – Remove Foods – Microbiota – Gut mucosa • Neurotransmitter biomarkers (Phase I) – Support Serotonin, GABA production – Reduce Clostridia • Foundational (Phase I): – B Minus - Multimineral – ALA - CoQ10 – Pulsed Lithium • Estrogen clearing/ GB (Phase II) – Glucaronidation • Calcium-D-Glucarate – Sulfation • DIM/I3C – Methylation (Phase III) • Hydroxy B12/Adensyl • 400 mcg 5-MTHF 17

Gut Rules

• http://ubiome.com

Whats really in your gut?

Stress Relief; Sarah dog is not allowed on the sofa

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